General Information of the Protein
Protein ID
PT06936
Protein Name
Chloride anion exchanger
Secondarily
Protein Name
Down-regulated in adenoma
Solute carrier family 26 member 3
Gene Name
SLC26A3
Secondarily
Gene Name
Dra
Sequence
MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELSSSSTENDSFIEEKVMVAASVTVLSGIIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLPVPAYSDPFSIFKVLESVFTQIQKTNIADLVTSVIILVVVFVFKEINQRYRSKLPVPIPIELIMTVIATGVSYGCNFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF
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Organism
Mus musculus, Mouse
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC26 family of anion exchangers
Function
Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:10428871). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:21976599).
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Uniprot ID
Primary ID:
Q9WVC8

Secondarily ID:
B2RTD9
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Ensembl ID
ENSG00000091138
Subcellular Location
Apical cell membrane
Membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000259 , FRT
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0435504
 Compound Info 
2-[4,8-dimethyl-2-oxo-7-[[3-(trifluoromethyl)phenyl]methoxy]chromen-3-yl]acetic acid
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C21H17F3O5
  2
1
IC50 = 23 nM
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2
IC50 = 25 nM
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CP0427276
 Compound Info 
2-[7-[(3-iodophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17IO5
  2
1
IC50 = 35 nM
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2
IC50 = 40 nM
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CP0569830
 Compound Info 
2-[7-[[3-fluoro-5-(trifluoromethyl)phenyl]methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C21H16F4O5
  1
1
IC50 = 60 nM
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CP0475510
 Compound Info 
2-[7-[(3-cyclopropylphenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C23H22O5
  1
1
IC50 = 70 nM
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CP0491683
 Compound Info 
2-[7-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C21H16F4O5
  1
1
IC50 = 100 nM
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CP0542801
 Compound Info 
2-[7-[(3-bromophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17BrO5
  1
1
IC50 = 150 nM
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CP0491686
 Compound Info 
2-[7-[(3-chlorophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17ClO5
  2
1
IC50 = 200 nM
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2
IC50 = 1000 nM
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CP0438485
 Compound Info 
2-[7-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C22H16F6O5
  2
1
IC50 = 300 nM
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2
IC50 = 15000 nM
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CP0569836
 Compound Info 
2-[4,8-dimethyl-2-oxo-7-[[5-(trifluoromethyl)furan-2-yl]methoxy]chromen-3-yl]acetic acid
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C19H15F3O6
  1
1
IC50 = 300 nM
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CP0477469
 Compound Info 
7-[(3-bromophenyl)methoxy]-N-hydroxy-8-methyl-2-oxochromene-3-carboxamide
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C18H14BrNO5
  1
1
IC50 = 450 nM
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CP0531016
 Compound Info 
2-[4,8-dimethyl-7-[(3-methylphenyl)methoxy]-2-oxochromen-3-yl]acetic acid
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C21H20O5
  2
1
IC50 = 480 nM
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2
IC50 = 500 nM
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CP0531017
 Compound Info 
2-[4,8-dimethyl-7-[(3-nitrophenyl)methoxy]-2-oxochromen-3-yl]acetic acid
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C20H17NO7
  1
1
IC50 = 500 nM
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CP0950475
 Compound Info 
2-[7-[(2-fluorophenyl)methoxy]-4,8-dimethyl-2-oxo-chromen-3-yl]acetic acid
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C20H17FO5
  1
1
IC50 = 510 nM
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CP0531015
 Compound Info 
2-[7-[(3,5-dimethylphenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C22H22O5
  2
1
IC50 = 540 nM
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2
IC50 = 15000 nM
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CP0479457
 Compound Info 
2-[7-[(3-fluorophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17FO5
  2
1
IC50 = 840 nM
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2
IC50 = 900 nM
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CP0495253
 Compound Info 
2-(4,8-dimethyl-2-oxo-7-pentoxychromen-3-yl)acetic acid
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C18H22O5
  2
1
IC50 = 1000 nM
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2
IC50 = 1200 nM
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CP0562417
 Compound Info 
2-(7-hexoxy-4,8-dimethyl-2-oxochromen-3-yl)acetic acid
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C19H24O5
  1
1
IC50 = 1500 nM
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CP0569832
 Compound Info 
2-(7-butoxy-4,8-dimethyl-2-oxochromen-3-yl)acetic acid
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C17H20O5
  1
1
IC50 = 1500 nM
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CP0951056
 Compound Info 
N-(3-chloro-4-methyl-phenyl)-2-(1-phenylimidazol-2-yl)sulfanyl-acetamide
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C18H16ClN3OS
  1
1
IC50 = 1500 nM
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CP0943733
 Compound Info 
2-[1-(4-chlorophenyl)imidazol-2-yl]sulfanyl-N-(p-tolyl)acetamide
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C18H16ClN3OS
  1
1
IC50 = 1600 nM
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CP0951244
 Compound Info 
N-(4-chlorophenyl)-2-[1-(4-ethoxyphenyl)imidazol-2-yl]sulfanyl-acetamide
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C19H18ClN3O2S
  1
1
IC50 = 1700 nM
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CP0969213
 Compound Info 
N-(4-chlorophenyl)-2-[1-(4-chlorophenyl)imidazol-2-yl]sulfanyl-acetamide
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C17H13Cl2N3OS
  1
1
IC50 = 1700 nM
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CP0491684
 Compound Info 
2-[7-(cyclopentylmethoxy)-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C19H22O5
  1
1
IC50 = 1800 nM
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CP0951054
 Compound Info 
2-[7-[(3,4-dichlorophenyl)methoxy]-4,8-dimethyl-2-oxo-chromen-3-yl]acetic acid
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C20H16Cl2O5
  1
1
IC50 = 1800 nM
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CP0968711
 Compound Info 
N-(4-bromophenyl)-2-[1-(4-chlorophenyl)imidazol-2-yl]sulfanyl-acetamide
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C17H13BrClN3OS
  1
1
IC50 = 1800 nM
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CP0943734
 Compound Info 
N-(4-bromophenyl)-2-[1-(4-methoxyphenyl)imidazol-2-yl]sulfanyl-acetamide
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C18H16BrN3O2S
  1
1
IC50 = 1900 nM
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CP0959273
 Compound Info 
N-(3-chloro-4-methyl-phenyl)-2-[1-(3,5-dimethylphenyl)imidazol-2-yl]sulfanyl-acetamide
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C20H20ClN3OS
  1
1
IC50 = 2100 nM
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CP0951058
 Compound Info 
N-(4-chlorophenyl)-2-[1-(3-chlorophenyl)imidazol-2-yl]sulfanyl-acetamide
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C17H13Cl2N3OS
  1
1
IC50 = 2200 nM
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CP0951057
 Compound Info 
N-(3,4-dichlorophenyl)-2-[1-(3,5-dimethylphenyl)imidazol-2-yl]sulfanyl-acetamide
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C19H17Cl2N3OS
  1
1
IC50 = 2500 nM
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CP0943735
 Compound Info 
N-(3,4-dichlorophenyl)-2-[1-(4-fluorophenyl)imidazol-2-yl]sulfanyl-acetamide
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C17H12Cl2FN3OS
  1
1
IC50 = 2600 nM
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CP0943736
 Compound Info 
2-[1-(3-chlorophenyl)imidazol-2-yl]sulfanyl-N-(3,4-dichlorophenyl)acetamide
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C17H12Cl3N3OS
  1
1
IC50 = 2900 nM
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CP0435502
 Compound Info 
2-[7-[(3-bromophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetamide
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C20H18BrNO4
  1
1
IC50 = 3300 nM
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CP0477462
 Compound Info 
2-[7-(cyclobutylmethoxy)-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C18H20O5
  1
1
IC50 = 3400 nM
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CP0852296
 Compound Info 
2-[1-(2,3-dimethylphenyl)imidazol-2-yl]sulfanyl-N-(4-ethylphenyl)acetamide
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C21H23N3OS
  1
1
IC50 = 3500 nM
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CP0475509
 Compound Info 
2-[7-[(2-iodophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17IO5
  1
1
IC50 = 4500 nM
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CP0477461
 Compound Info 
2-(7-cyclopentyloxy-4,8-dimethyl-2-oxochromen-3-yl)acetic acid
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C18H20O5
  1
1
IC50 = 4500 nM
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CP0951243
 Compound Info 
2-[7-[(4-tert-butylphenyl)methoxy]-4,8-dimethyl-2-oxo-chromen-3-yl]acetic acid
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C24H26O5
  1
1
IC50 = 4600 nM
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CP0969672
 Compound Info 
N-(4-chlorophenyl)-2-[1-(3,5-dimethylphenyl)imidazol-2-yl]sulfanyl-acetamide
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C19H18ClN3OS
  1
1
IC50 = 4600 nM
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CP0951055
 Compound Info 
3-[7-[(2,5-dimethylphenyl)methoxy]-4,8-dimethyl-2-oxo-chromen-3-yl]propanoic acid
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C23H24O5
  1
1
IC50 = 4700 nM
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CP0967569
 Compound Info 
N-(4-chlorophenyl)-2-[1-(3-methoxyphenyl)imidazol-2-yl]sulfanyl-acetamide
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C18H16ClN3O2S
  1
1
IC50 = 4700 nM
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CP0239455
 Compound Info 
3-(4,8-dimethyl-2-oxo-7-phenylmethoxychromen-3-yl)propanoic acid
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C21H20O5
  1
1
IC50 = 5100 nM
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CP0959274
 Compound Info 
2-[1-(3-chlorophenyl)imidazol-2-yl]sulfanyl-N-(p-tolyl)acetamide
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C18H16ClN3OS
  1
1
IC50 = 5100 nM
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CP0944328
 Compound Info 
2-[1-(4-chlorophenyl)imidazol-2-yl]sulfanyl-N-(4-ethylphenyl)acetamide
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C19H18ClN3OS
  1
1
IC50 = 5700 nM
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CP0969673
 Compound Info 
N-(4-chlorophenyl)-2-[1-(m-tolyl)imidazol-2-yl]sulfanyl-acetamide
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C18H16ClN3OS
  1
1
IC50 = 6200 nM
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CP0969674
 Compound Info 
N-(4-bromophenyl)-2-[1-(m-tolyl)imidazol-2-yl]sulfanyl-acetamide
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C18H16BrN3OS
  1
1
IC50 = 6400 nM
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CP0716264
 Compound Info 
N-(4-ethylphenyl)-2-[1-(4-methoxyphenyl)imidazol-2-yl]sulfanyl-acetamide
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C20H21N3O2S
  1
1
IC50 = 6500 nM
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CP0969606
 Compound Info 
2-[1-(3-methoxyphenyl)imidazol-2-yl]sulfanyl-N-(p-tolyl)acetamide
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C19H19N3O2S
  1
1
IC50 = 7100 nM
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CP0912526
 Compound Info 
2-[1-(4-chlorophenyl)imidazol-2-yl]sulfanyl-N-(4-nitrophenyl)acetamide
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C17H13ClN4O3S
  1
1
IC50 = 7400 nM
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CP0470381
 Compound Info 
2-[7-(2-bromobenzyl)oxy-2-keto-4,8-dimethyl-chromen-3-yl]acetic acid
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C20H17BrO5
  1
1
IC50 = 10000 nM
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CP0969276
 Compound Info 
N-(3-chloro-4-methyl-phenyl)-2-[1-(4-chlorophenyl)imidazol-2-yl]sulfanyl-acetamide
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C18H15Cl2N3OS
  1
1
IC50 = 11000 nM
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CP0969214
 Compound Info 
2-[1-(4-chlorophenyl)imidazol-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide
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C18H13ClF3N3OS
  1
1
IC50 = 12000 nM
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CP0435503
 Compound Info 
2-[7-[(2-chlorophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17ClO5
  1
1
IC50 = 18000 nM
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CP0435501
 Compound Info 
7-[(3-iodophenyl)methoxy]-8-methyl-2-oxochromene-3-carboxylic acid
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C18H13IO5
  1
1
IC50 > 5000 nM
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CP0477460
 Compound Info 
2-[4,8-dimethyl-2-oxo-7-[[6-(trifluoromethyl)pyridin-2-yl]methoxy]chromen-3-yl]acetic acid
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C20H16F3NO5
  1
1
IC50 > 5000 nM
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CP0477463
 Compound Info 
2-[4,8-dimethyl-2-oxo-7-(pyridin-3-ylmethoxy)chromen-3-yl]acetic acid
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C19H17NO5
  1
1
IC50 > 5000 nM
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CP0477464
 Compound Info 
2-[7-[[6-(hydroxymethyl)pyridin-2-yl]methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H19NO6
  1
1
IC50 > 5000 nM
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CP0491685
 Compound Info 
2-[4,8-dimethyl-2-oxo-7-(2-pyrrol-1-ylethoxy)chromen-3-yl]acetic acid
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C19H19NO5
  1
1
IC50 > 5000 nM
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CP0518423
 Compound Info 
7-[(3-bromophenyl)methoxy]-8-methyl-2-oxochromene-3-carboxylic acid
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C18H13BrO5
  1
1
IC50 > 5000 nM
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CP0518424
 Compound Info 
2-[7-[(4-iodophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17IO5
  1
1
IC50 > 5000 nM
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CP0518425
 Compound Info 
2-[7-[(4-bromophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17BrO5
  1
1
IC50 > 5000 nM
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CP0518426
 Compound Info 
2-[7-[(4-chlorophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C20H17ClO5
  1
1
IC50 > 5000 nM
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CP0519835
 Compound Info 
2-[7-(carboxymethoxy)-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C15H14O7
  1
1
IC50 > 5000 nM
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CP0519836
 Compound Info 
3-[7-[(3-iodophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]propanoic acid
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C21H19IO5
  1
1
IC50 > 5000 nM
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CP0543638
 Compound Info 
2-(4,8-dimethyl-2-oxo-7-propoxychromen-3-yl)acetic acid
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C16H18O5
  1
1
IC50 > 5000 nM
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CP0543639
 Compound Info 
3-[7-[(3-bromophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]propanoic acid
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C21H19BrO5
  1
1
IC50 > 5000 nM
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CP0550846
 Compound Info 
2-[4,8-dimethyl-7-(3-methylphenyl)sulfonyloxy-2-oxochromen-3-yl]acetic acid
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C20H18O7S
  1
1
IC50 > 5000 nM
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CP0562415
 Compound Info 
7-[(3-bromophenyl)methoxy]-8-methyl-2-oxochromene-3-carboxamide
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C18H14BrNO4
  1
1
IC50 > 5000 nM
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CP0562416
 Compound Info 
2-(4,8-dimethyl-2-oxo-7-prop-2-enoxychromen-3-yl)acetic acid
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C16H16O5
  1
1
IC50 > 5000 nM
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CP0562418
 Compound Info 
2-[7-(3-chlorophenyl)sulfonyloxy-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C19H15ClO7S
  1
1
IC50 > 5000 nM
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CP0569831
 Compound Info 
2-[7-(2-methoxyethoxy)-4,8-dimethyl-2-oxochromen-3-yl]acetic acid
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C16H18O6
  1
1
IC50 > 5000 nM
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CP0569834
 Compound Info 
2-[4,8-dimethyl-2-oxo-7-(pyridin-4-ylmethoxy)chromen-3-yl]acetic acid
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C19H17NO5
  1
1
IC50 > 5000 nM
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CP0569835
 Compound Info 
2-[4,8-dimethyl-2-oxo-7-(pyridin-2-ylmethoxy)chromen-3-yl]acetic acid
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C19H17NO5
  1
1
IC50 > 5000 nM
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CP0569837
 Compound Info 
2-[4,8-dimethyl-2-oxo-7-[2-[3-(trifluoromethyl)phenyl]ethoxy]chromen-3-yl]acetic acid
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C22H19F3O5
  1
1
IC50 > 5000 nM
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