General Information of the Protein
Protein ID
PT06826
Protein Name
Anoctamin-2
Secondarily
Protein Name
Transmembrane protein 16B
Gene Name
ANO2
Secondarily
Gene Name
C12orf3
TMEM16B
Sequence
MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Other ion channel
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Chloride channel
>
Calcium-activated chloride channel
Function
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
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Uniprot ID
Primary ID:
Q9NQ90

Secondarily ID:
C4N787
Q9H847
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Ensembl ID
ENSG00000047617
HGNC ID
HGNC:1183
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000259 , FRT
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0458303
 Compound Info 
2-[(2-chloro-2,2-difluoroacetyl)amino]-N-(2-methylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
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C19H19ClF2N2O2S
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0469978
 Compound Info 
2-[(2-bromo-2,2-difluoroacetyl)amino]-N-(2-methylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
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C19H19BrF2N2O2S
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0412850
 Compound Info 
2-[(2,2-difluoro-2-iodoacetyl)amino]-N-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
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C18H16F3IN2O2S
  1
1
IC50 = 1100 nM
 Bioactivity Info 
   TI
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CP0143428
 Compound Info 
N-(2-methylphenyl)-2-[(2,2,2-trifluoroacetyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
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C19H19F3N2O2S
  1
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
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CP0458300
 Compound Info 
2-[(2,2-difluoro-2-iodoacetyl)amino]-N-(2-methylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
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C19H19F2IN2O2S
  1
1
IC50 = 1400 nM
 Bioactivity Info 
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CP0469979
 Compound Info 
2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetamide
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C19H20N4O3S2
  1
1
IC50 = 4000 nM
 Bioactivity Info 
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CP0474318
 Compound Info 
N-phenyl-2-[(2,2,2-trifluoroacetyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
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C18H17F3N2O2S
  1
1
IC50 = 4600 nM
 Bioactivity Info 
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CP0466739
 Compound Info 
2-[(4-chloro-2-methylphenoxy)methyl]-5-(2-methoxyphenyl)-1,3,4-oxadiazole
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C17H15ClN2O3
  1
1
IC50 = 12400 nM
 Bioactivity Info 
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CP0458304
 Compound Info 
2-[(4-methoxynaphthalen-2-yl)amino]-5-nitrobenzoic acid
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C18H14N2O5
  1
1
IC50 = 13000 nM
 Bioactivity Info 
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CP0427069
 Compound Info 
2-(4-chloro-2-methylphenoxy)-N-[(E)-(2-methoxyphenyl)methylideneamino]acetamide
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C17H17ClN2O3
  2
1
IC50 > 20000 nM
 Bioactivity Info 
   TI
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2
IC50 > 100000 nM
 Bioactivity Info 
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CP0561407
 Compound Info 
ethyl 2-[2-[(E)-[[2-(4-chloro-2-methylphenoxy)acetyl]hydrazinylidene]methyl]phenoxy]-2-fluoroacetate
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C20H20ClFN2O5
  1
1
IC50 = 59400 nM
 Bioactivity Info 
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CP0422396
 Compound Info 
2-[(4-chloro-2-methylphenoxy)methyl]-5-(3-methoxyphenyl)-1,3,4-oxadiazole
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C17H15ClN2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0427073
 Compound Info 
2-[(4-chloro-2-methylphenoxy)methyl]-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole
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C17H12ClF3N2O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0458188
 Compound Info 
2-[(4-chloro-2-methylphenoxy)methyl]-5-(2-fluorophenyl)-1,3,4-oxadiazole
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C16H12ClFN2O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0472434
 Compound Info 
2-[(4-chloro-2-methylphenoxy)methyl]-5-(furan-2-yl)-1,3,4-oxadiazole
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C14H11ClN2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0476438
 Compound Info 
ethyl 3-[(E)-[[2-(4-chloro-2-methylphenoxy)acetyl]hydrazinylidene]methyl]indolizine-2-carboxylate
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C21H20ClN3O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0479104
 Compound Info 
2-(5-chloro-1-benzofuran-2-yl)-5-(2-methoxyphenyl)-1,3,4-oxadiazole
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C17H11ClN2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0487357
 Compound Info 
2-(4-chloro-2-methylphenoxy)-2-methyl-N-[(E)-[2-(trifluoromethoxy)phenyl]methylideneamino]propanamide
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C19H18ClF3N2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0492695
 Compound Info 
5-chloro-N-[(E)-(2-methoxyphenyl)methylideneamino]-1-benzofuran-2-carboxamide
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C17H13ClN2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0493697
 Compound Info 
2-(4-chloro-2-methylphenoxy)-N'-[(2-methoxyphenyl)methyl]acetohydrazide
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C17H19ClN2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0542487
 Compound Info 
2-(4-chloro-2-methylphenoxy)-2,2-difluoro-N-[(E)-[2-(trifluoromethoxy)phenyl]methylideneamino]acetamide
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C17H12ClF5N2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0547530
 Compound Info 
2-[(4-chloro-2-methylphenoxy)methyl]-5-(3-fluorophenyl)-1,3,4-oxadiazole
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C16H12ClFN2O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0547531
 Compound Info 
2-(4-chloro-2-methylphenoxy)-N-[(E)-pyridin-2-ylmethylideneamino]acetamide
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C15H14ClN3O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0547532
 Compound Info 
2-(4-chloro-2-methylphenoxy)-N-[(E)-1-[2-(trifluoromethoxy)phenyl]ethylideneamino]acetamide
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C18H16ClF3N2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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Cell Line ID: CL000006 , HEK293
 Cell Line Info