General Information of the Protein
| Protein ID |
PT06758
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| Protein Name |
Hematopoietic prostaglandin D synthase
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| Secondarily Protein Name |
GST class-sigma
Glutathione S-transferase
Glutathione-dependent PGD synthase
Glutathione-requiring prostaglandin D synthase
Prostaglandin-H2 D-isomerase
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| Gene Name |
HPGDS
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| Secondarily Gene Name |
Gsts
Pgds
Ptgds2
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| Sequence |
MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKPTLPFGKIPVLEVEGLTLHQSLAIARYLTKNTDLAGKTELEQCQVDAVVDTLDDFMSLFPWAEENQDLKERTFNDLLTRQAPHLLKDLDTYLGDKEWFIGNYVTWADFYWDICSTTLLVLKPDLLGIYPRLVSLRNKVQAIPAISAWILKRPQTKL
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| Organism |
Rattus norvegicus, Rat
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| Protein Classification |
Enzyme
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Transferase
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| Function |
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
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| Uniprot ID |
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| Ensembl ID | |||||
| Subcellular Location |
Cytoplasm
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000194 , RBL-1
