General Information of the Protein
Protein ID
PT06694
Protein Name
Ghrelin O-acyltransferase
Secondarily
Protein Name
Membrane-bound O-acyltransferase domain-containing protein 4
Gene Name
MBOAT4
Secondarily
Gene Name
Gm171
Goat
Sequence
MDWLQLFFLHPLSFYQGAAFPFALLFNYLCILDTFSTRARYLFLLAGGGVLAFAAMGPYSLLIFIPALCAVALVSFLSPQEVHRLTFFFQMGWQTLCHLGLHYTEYYLGEPPPVRFYITLSSLMLLTQRVTSLSLDICEGKVEAPRRGIRSKSSFSEHLWDALPHFSYLLFFPALLGGSLCSFRRFQACVQRSSSLYPSISFRALTWRGLQILGLECLKVALRSAVSAGAGLDDCQRLECIYLMWSTAWLFKLTYYSHWILDDSLLHAAGFGAEAGQGPGEEGYVPDVDIWTLETTHRISLFARQWNRSTALWLRRLVFRKSRRWPLLQTFAFSAWWHGLHPGQVFGFLCWSVMVKADYLIHTFANVCIRSWPLRLLYRALTWAHTQLIIAYIMLAVEGRSLSSLCQLCCSYNSLFPVMYGLLLFLLAERKDKRN
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:18267071, PubMed:24045953, PubMed:28134508, PubMed:18669668, PubMed:18443287, PubMed:19501572). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:19501572).
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Uniprot ID
Primary ID:
P0C7A3

Secondarily ID:
B1Q004
B2RWL6
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Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000524 , HEK293-FT
Compound ID Compound Name Compound Formula
CP0238064
CDDO-Me, 2
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C32H43NO4
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0379806
CDDO-EA, 3
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C33H46N2O3
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05904 Ghrelin O-acyltransferase Homo sapiens, Human