General Information of the Protein
Protein ID
PT05904
Protein Name
Ghrelin O-acyltransferase
Secondarily
Protein Name
Membrane-bound O-acyltransferase domain-containing protein 4
Gene Name
MBOAT4
Secondarily
Gene Name
GOAT
OACT4
FKSG89
Sequence
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:24045953, PubMed:18443287, PubMed:25562443, PubMed:28134508). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:18443287).
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Uniprot ID
Primary ID:
Q96T53

Secondarily ID:
B1Q003
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HGNC ID
HGNC:32311
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0379806
 Compound Info 
CDDO-EA, 3
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C33H46N2O3
  1
1
IC50 = 8000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238064
 Compound Info 
CDDO-Me, 2
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C32H43NO4
  1
1
IC50 = 23000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0425906
 Compound Info 
(4aR,6aR,6aS,6bR,8aS,12aS,14bS)-8a-(imidazole-1-carbonyl)-3,13-diketo-4,4,6a,6b,11,11,14b-heptamethyl-4a,5,6,6a,7,8,9,10,12,12a-decahydropicene-2-carbonitrile
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C34H43N3O3
  1
1
IC50 = 38000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0574845
 Compound Info 
CDDO-TFEA, 4
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C33H43F3N2O3
  1
1
IC50 = 44000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0040077
 Compound Info 
(3beta)-3-hydroxyurs-12-en-28-oic acid
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C30H48O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0772201
 Compound Info 
2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid
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C31H41NO4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0494797
 Compound Info 
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-3-[4-(3-phenylpropyl)triazol-1-yl]propanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
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C34H47N9O6
  1
1 IC50 = 700 nM
Clinical Information about the Protein
Target 1 ( Ghrelin O acyltransferase (GOAT) )
Target Type Patented-recorded Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06694 Ghrelin O-acyltransferase Mus musculus, Mouse
 Protein Info