General Information of the Protein
Protein ID
PT06622
Protein Name
X-box-binding protein 1
Secondarily
Protein Name
Hepatocarcinogenesis-related transcription factor
Gene Name
XBP1
Secondarily
Gene Name
Htf
Sequence
MVVVAAAPSAASAAPKVLLLSGQPASGGRALPLMVPGPRAAGSEASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLQLENQLLREKTHGLVIENQELRTRLGMNALVTEEVSEAESKGNGVRLVAGSAESAALRLRAPLQQVQAQLSPPQNIFPWILTLLPLQILSLISFWAFWTSWTLSCFSNVLPQSLLIWRNSQRSTQKDLVPYQPPFLCQWGPHQPSWKPLMNSFVLTMYTPSL
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Organism
Rattus norvegicus, Rat
Protein Classification
Transcription factor
Function
Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention.
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Uniprot ID
Q9R1S4
Subcellular Location
Nucleus
Endoplasmic reticulum
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000663 , IEC-6
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0533972
 Compound Info 
N-(4-methylphenyl)-5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-imine
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C26H20N2O4
  1
1
EC50 = 13.2 nM
 Bioactivity Info 
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CP0482956
 Compound Info 
N-(5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-ylidene)pentanamide
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C24H22N2O5
  1
1
EC50 = 32.5 nM
 Bioactivity Info 
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CP0460962
 Compound Info 
N-(4-bromophenyl)-5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-imine
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C25H17BrN2O4
  1
1
EC50 = 48.9 nM
 Bioactivity Info 
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CP0544526
 Compound Info 
N-(5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-ylidene)hexanamide
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C25H24N2O5
  1
1
EC50 = 70.8 nM
 Bioactivity Info 
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CP0473125
 Compound Info 
5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-one
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C19H13NO5
  2
1
EC50 = 79.8 nM
 Bioactivity Info 
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2
EC50 = 80 nM
 Bioactivity Info 
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CP0544525
 Compound Info 
N-phenyl-5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-imine
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C25H18N2O4
  1
1
EC50 = 113 nM
 Bioactivity Info 
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CP0490335
 Compound Info 
N-(4-chlorophenyl)-5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-imine
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C25H17ClN2O4
  1
1
EC50 = 174 nM
 Bioactivity Info 
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CP0567874
 Compound Info 
N-(4-methoxyphenyl)-5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-imine
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C26H20N2O5
  1
1
EC50 = 184 nM
 Bioactivity Info 
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CP0539623
 Compound Info 
N-(5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-ylidene)butanamide
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C23H20N2O5
  1
1
EC50 = 199 nM
 Bioactivity Info 
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CP0574784
 Compound Info 
N-(5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-ylidene)acetamide
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C21H16N2O5
  1
1
EC50 = 283 nM
 Bioactivity Info 
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CP0460963
 Compound Info 
N-(5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-ylidene)propanamide
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C22H18N2O5
  1
1
EC50 = 289 nM
 Bioactivity Info 
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CP0466908
 Compound Info 
(1S,2R,4S,7R,8R,10Z,12R)-1,7,11-trimethyl-4-propan-2-yl-15,16-dioxatricyclo[10.2.1.14,7]hexadec-10-ene-2,8-diol
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C20H34O4
  1
1
EC50 = 340 nM
 Bioactivity Info 
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CP0490283
 Compound Info 
N-(4-fluorophenyl)-5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(24),2,4(8),9,15(23),16(20),21-heptaen-14-imine
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C25H17FN2O4
  1
1
EC50 = 346 nM
 Bioactivity Info 
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CP0407579
 Compound Info 
(1S,3R,5R,8E,12R,13R)-12-hydroxy-5,9,13-trimethyl-1-propan-2-yl-4,16-dioxatricyclo[11.2.1.03,5]hexadec-8-en-10-one
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C20H32O4
  1
1
EC50 = 420 nM
 Bioactivity Info 
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CP0403029
 Compound Info 
(1S,3R,5R,7S,8E,12R,13R)-7,12-dihydroxy-5,9,13-trimethyl-1-propan-2-yl-4,16-dioxatricyclo[11.2.1.03,5]hexadec-8-en-10-one
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C20H32O5
  1
1
EC50 = 880 nM
 Bioactivity Info 
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CP0519877
 Compound Info 
(1S,3R,5R,8Z,12R,13R)-12-hydroxy-5,13-dimethyl-1-propan-2-yl-4,16-dioxatricyclo[11.2.1.03,5]hexadec-8-ene-9-carbaldehyde
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C20H32O4
  1
1
EC50 = 1140 nM
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Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06096 X-box-binding protein 1 Homo sapiens, Human
 Protein Info