General Information of the Protein
Protein ID
PT06555
Protein Name
Ileal sodium/bile acid cotransporter
Secondarily
Protein Name
Apical sodium-dependent bile acid transporter
Ileal Na(+)/bile acid cotransporter
Ileal sodium-dependent bile acid transporter
Na(+)-dependent ileal bile acid transporter
Sodium/taurocholate-cotransporting polypeptide
ileal
Solute carrier family 10 member 2
Gene Name
SLC10A2
Secondarily
Gene Name
Ntcp2
Sequence
MDNSSVCSPNATFCEGDSCLVTESNFNAILSTVMSTVLTILLAMVMFSMGCNVEINKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFIYTKMWVDSGTIVIPYDSIGISLVALVIPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVFAAIILGMYVTYKKCHGKNDAEFLEKTDNDMDPMPSFQETNKGFQPDEK
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC10 family of sodium-bile acid co-transporters
Function
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7860756). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).
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Uniprot ID
Q62633
Ensembl ID
ENSG00000125255
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0508776
 Compound Info 
2-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1lambda6,4-benzothiazepin-8-yl]methylamino]acetic acid
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C25H34N2O5S
  1
1
IC50 = 0.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0351731
 Compound Info 
[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1lambda6,4-benzothiazepin-8-yl]methylphosphonic acid
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C23H32NO6PS
  1
1
IC50 = 0.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396473
 Compound Info 
BDBM50434858
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C28H38N2O7S
  1
1
IC50 = 1.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0394907
 Compound Info 
2-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1lambda6,4-benzothiazepin-8-yl]methylamino]ethanesulfonic acid
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C25H36N2O6S2
  1
1
IC50 = 2.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407416
 Compound Info 
(7R,9R)-7-Butyl-7-ethyl-2,3-dimethoxy-9-phenyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocycloheptene 5,5-dioxide
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C23H31NO4S
  1
1
IC50 = 22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT06643 Ileal sodium/bile acid cotransporter Mus musculus, Mouse
 Protein Info