General Information of the Protein
Protein ID
PT06506
Protein Name
Butyrophilin subfamily 3 member A1
Gene Name
BTN3A1
Secondarily
Gene Name
BTF5
Sequence
MKMASFLAFLLLNFRVCLLLLQLLMPHSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVADGVGLYAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAGTLPVLLLLLGGAGYFLWQQQEEKKTQFRKKKREQELREMAWSTMKQEQSTRVKLLEELRWRSIQYASRGERHSAYNEWKKALFKPADVILDPKTANPILLVSEDQRSVQRAKEPQDLPDNPERFNWHYCVLGCESFISGRHYWEVEVGDRKEWHIGVCSKNVQRKGWVKMTPENGFWTMGLTDGNKYRTLTEPRTNLKLPKPPKKVGVFLDYETGDISFYNAVDGSHIHTFLDVSFSEALYPVFRILTLEPTALTICPA
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
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Uniprot ID
Primary ID:
O00481

Secondarily ID:
A2A278
A8K2C8
B4DIQ1
B4DRM2
E9PGB4
E9PHG8
Q0P515
Q147X5
Q53F15
Q99420
Q9HCY1
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Ensembl ID
ENSG00000026950
HGNC ID
HGNC:1138
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000002 , K-562
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0432572
 Compound Info 
ethyl (2S)-2-[[[(E)-5-hydroxy-4-methylpent-3-enyl]-phenoxyphosphoryl]amino]propanoate
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C17H26NO5P
  3
1
EC50 = 21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 79 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
EC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0462120
 Compound Info 
ethyl (2S)-2-[[[(E)-5-hydroxy-4-methylpent-3-enyl]-phenoxyphosphoryl]amino]propanoate
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C17H26NO5P
  3
1
EC50 = 43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
EC50 = 460 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416702
 Compound Info 
ethyl 2-[[[(E)-5-hydroxy-4-methylpent-3-enyl]-phenoxyphosphoryl]amino]acetate
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C16H24NO5P
  3
1
EC50 = 51 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 230 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
EC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0875884
 Compound Info 
(E)-4-hydroxy-3-methyl-but-2-enyl diphosphate
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C6H11Na3O7P2
  3
1
EC50 = 280 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
EC50 = 7600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416703
 Compound Info 
ethyl (2R)-2-[[[(E)-5-hydroxy-4-methylpent-3-enyl]-phenoxyphosphoryl]amino]propanoate
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C17H26NO5P
  3
1
EC50 = 430 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
EC50 = 4600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416705
 Compound Info 
ethyl (2R)-2-[[[(E)-5-hydroxy-4-methylpent-3-enyl]-phenoxyphosphoryl]amino]propanoate
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C17H26NO5P
  3
1
EC50 = 520 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
EC50 = 6000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0038529
 Compound Info 
2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
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C5H10N2O7P2
  3
1
EC50 = 23000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 79000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416704
 Compound Info 
trisodium;[[(E)-4-hydroxy-3-methylbut-2-enoxy]-oxidophosphoryl] phosphate
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C5H9Na3O8P2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS