General Information of the Protein
Protein ID |
PT06427
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Protein Name |
Genome polyprotein
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Secondarily Protein Name |
VP4-VP2
P1A
Virion protein 4
P1B
Virion protein 2
P1C
Virion protein 3
P1D
Virion protein 1
Picornain 2A
Protein 2A
Protein 3B
Picornain 3C
3D polymerase
Protein 3D
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Sequence |
MGSQVSTQRSGSHENSNSATEGSTINYTTINYYKDSYAATAGKQSLKQDPDKFANPVKDIFTEMAAPLKSPSAEACGYSDRVAQLTIGNSTITTQEAANIIVGYGEWPSYCSDNDATAVDKPTRPDVSVNRFYTLDTKLWEKSSKGWYWKFPDVLTETGVFGPNAQFHYLYRSGFCIHVQCNASKFHQGALLVAVLPEYVIGTVAGGTGTENSHPPYKQTQPGADGFELQHPYVLDAGIPISQLTVCPHQWINLRTNNCATIIVPYMNTLPFDSALNHCNFGLLVVPISPLDFDQGATPVIPITITLAPMCSEFAGLRQAVTQGFPTELKPGTNQFLTTDDGVSAPILPNFHPTPCIHIPGEVRNLLELCQVETILEVNNVPTNATSLMERLRFPVSAQAGKGELCAVFRADPGRDGPWQSTMLGQLCGYYTQWSGSLEVTFMFTGSFMATGKMLIAYTPPGGPLPKDRATAMLGTHVIWDFGLQSSVTLVIPWISNTHYRAHARDGVFDYYTTGLVSIWYQTNYVVPIGAPNTAYIIALAAAQKNFTMKLCKDTSDILETATIQGDRVADVIESSIGDSVSKALTPALPAPTGPDTQVSSHRLDTGKVPALQAAEIGASSNASDESMIETRCVLNSHSTAETTLDSFFSRAGLVGEIDLPLKGTTNPNGYANWDIDITGYAQMRRKVELFTYMRFDAEFTFVACTPTGRVVPQLLQYMFVPPGAPKPDSRDSLAWPTATNPSVFVKSSDPPAQVSVPFMSPASAYQWFYDGYPTFGEHKQEKDLEYGACPNNMMGTFSVRTVGSSKSEYSLVIRIYMRMKHVRAWIPRPMRNQNYLFKSNPNYAGDSIKPTGTSRTAITTLGKFGQQSGAIYVGNFRVVNRHLATHTDWANLVWEDSSRDLLVSSTTAQGCDTIARCNCQTGVYYCNSRRKHYPVSFSKPSLVFVEASEYYPARYQSHLMLAEGHSEPGDCGGILRCQHGVVGIVSTGGSGLVGFADVRDLLWLDEEAMEQGVSDYIKGLGRAFGTGFTDAVSREVEALKNHLIGSEGAVEKILKNLVKLISALVIVIRSDYDMVTLTATLALIGCHGSPWAWIKSKTASILGIPMAQKQSASWLKKFNDMANAAKGLEWIFNKISKFIDWLKEKIIPAAKEKVEFLNNLKQLPLLENQVSNLEQSAASQEDLEAMFGNVIYLAHFCRKFQPLYATEAKRVYALEKRMNNYMQFKSKHRIEPVCLIIRGSPGTGKSLATGIIARAIADKYRSSVYSLPPDPDHFDGYKQQVVAVMDDLCQNPDGKDMSLFCQMVSTVDFVPPMASLEEKGVSFTSKFVIASTNASNIIVPTVSDSDAIRRRFYMDCDIEVTDSYKTDLGRLDAGRAAKLCTENNTANFKRCSPLVCGKAIQLRDRKSKVRYSVDTVVSELIREYNNRSAIGNTIEALFQGPPKFRPIRISLEEKPAPDAISDLLASVDSEEVRQYCREQGWIIPETPTNVERHLNRAVLVMQSIATVVAVVSLVYVIYKLFAGFQGAYSGAPKPILKKPVLRTATVQGPSLDFALSLLRRNIRQAQTDQGHFTMLGVRDRLAILPRHSQPGKTIWVEHKLINVLDAVELVDEQGVNLELTLVTLDTNEKFRDITKCIPEVITGASDATLVINTEHIPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKPGQCGGVVTSVGKIIGIHIGGNGRQAFCAGLKRSYFASEQGEIQWMKPNRETGRLNINGPTRTKLEPSVFHDVFEGNKEPAVLTSKDPRLEVDFEQALFSKYVGNTLHEPDEYVTQAALHYANQLKQLDINTSKMSMEEACYGTEYLEAIDLHTSAGYPYSALGIKKRDILDPVTRDTSRMKLYMDKYGLDLPNSTYVKDELSSLDKIRKGESRLIEASSLNDPVYPRLTFGHLYEVFHANPGTVTGSAVGCNPDVFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALELVLREIGYSEEAVSLIEGINHTHHVYRNKTYCVLGGMPSGCSGTSIFNSMINNIIIRTLLIKTFKGIDLDELKMVAYGDDVLASYPFPIDCLEWGKTGKEYGLTMTPADKSPCFNEVTWENATFLKRGFLPDHQFPFLIHPTMPMREIHESIRWTKDARNTQDHVRSLCLLAWHNGKEEYEKFVSTIRSVPIGRALAIPNLENLRRNWLELF
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Organism |
Human enterovirus 71 (strain USA/BrCr/1970), EV71, EV-71
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Protein Classification |
Enzyme
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Transferase
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Function |
Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3 (By similarity). The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome (By similarity). Capsid protein VP1 mainly forms the vertices of the capsid (By similarity). Capsid protein VP1, together with VP2, interacts with host cell receptor SCARB2 to provide virion attachment to target host cells. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (PubMed:20956521, PubMed:37417384). After binding to its receptor, the capsid undergoes conformational changes (By similarity). Capsid protein VP1 N-terminus (that contains an amphipathic alpha-helix) and capsid protein VP4 are externalized (By similarity). Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm (By similarity).
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Uniprot ID | |||||
Subcellular Location |
Virion
Host cytoplasm
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Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000264 , RD