General Information of the Protein
Protein ID
PT06427
Protein Name
Genome polyprotein
Secondarily
Protein Name
VP4-VP2
P1A
Virion protein 4
P1B
Virion protein 2
P1C
Virion protein 3
P1D
Virion protein 1
Picornain 2A
Protein 2A
Protein 3B
Picornain 3C
3D polymerase
Protein 3D
Sequence
MGSQVSTQRSGSHENSNSATEGSTINYTTINYYKDSYAATAGKQSLKQDPDKFANPVKDIFTEMAAPLKSPSAEACGYSDRVAQLTIGNSTITTQEAANIIVGYGEWPSYCSDNDATAVDKPTRPDVSVNRFYTLDTKLWEKSSKGWYWKFPDVLTETGVFGPNAQFHYLYRSGFCIHVQCNASKFHQGALLVAVLPEYVIGTVAGGTGTENSHPPYKQTQPGADGFELQHPYVLDAGIPISQLTVCPHQWINLRTNNCATIIVPYMNTLPFDSALNHCNFGLLVVPISPLDFDQGATPVIPITITLAPMCSEFAGLRQAVTQGFPTELKPGTNQFLTTDDGVSAPILPNFHPTPCIHIPGEVRNLLELCQVETILEVNNVPTNATSLMERLRFPVSAQAGKGELCAVFRADPGRDGPWQSTMLGQLCGYYTQWSGSLEVTFMFTGSFMATGKMLIAYTPPGGPLPKDRATAMLGTHVIWDFGLQSSVTLVIPWISNTHYRAHARDGVFDYYTTGLVSIWYQTNYVVPIGAPNTAYIIALAAAQKNFTMKLCKDTSDILETATIQGDRVADVIESSIGDSVSKALTPALPAPTGPDTQVSSHRLDTGKVPALQAAEIGASSNASDESMIETRCVLNSHSTAETTLDSFFSRAGLVGEIDLPLKGTTNPNGYANWDIDITGYAQMRRKVELFTYMRFDAEFTFVACTPTGRVVPQLLQYMFVPPGAPKPDSRDSLAWPTATNPSVFVKSSDPPAQVSVPFMSPASAYQWFYDGYPTFGEHKQEKDLEYGACPNNMMGTFSVRTVGSSKSEYSLVIRIYMRMKHVRAWIPRPMRNQNYLFKSNPNYAGDSIKPTGTSRTAITTLGKFGQQSGAIYVGNFRVVNRHLATHTDWANLVWEDSSRDLLVSSTTAQGCDTIARCNCQTGVYYCNSRRKHYPVSFSKPSLVFVEASEYYPARYQSHLMLAEGHSEPGDCGGILRCQHGVVGIVSTGGSGLVGFADVRDLLWLDEEAMEQGVSDYIKGLGRAFGTGFTDAVSREVEALKNHLIGSEGAVEKILKNLVKLISALVIVIRSDYDMVTLTATLALIGCHGSPWAWIKSKTASILGIPMAQKQSASWLKKFNDMANAAKGLEWIFNKISKFIDWLKEKIIPAAKEKVEFLNNLKQLPLLENQVSNLEQSAASQEDLEAMFGNVIYLAHFCRKFQPLYATEAKRVYALEKRMNNYMQFKSKHRIEPVCLIIRGSPGTGKSLATGIIARAIADKYRSSVYSLPPDPDHFDGYKQQVVAVMDDLCQNPDGKDMSLFCQMVSTVDFVPPMASLEEKGVSFTSKFVIASTNASNIIVPTVSDSDAIRRRFYMDCDIEVTDSYKTDLGRLDAGRAAKLCTENNTANFKRCSPLVCGKAIQLRDRKSKVRYSVDTVVSELIREYNNRSAIGNTIEALFQGPPKFRPIRISLEEKPAPDAISDLLASVDSEEVRQYCREQGWIIPETPTNVERHLNRAVLVMQSIATVVAVVSLVYVIYKLFAGFQGAYSGAPKPILKKPVLRTATVQGPSLDFALSLLRRNIRQAQTDQGHFTMLGVRDRLAILPRHSQPGKTIWVEHKLINVLDAVELVDEQGVNLELTLVTLDTNEKFRDITKCIPEVITGASDATLVINTEHIPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKPGQCGGVVTSVGKIIGIHIGGNGRQAFCAGLKRSYFASEQGEIQWMKPNRETGRLNINGPTRTKLEPSVFHDVFEGNKEPAVLTSKDPRLEVDFEQALFSKYVGNTLHEPDEYVTQAALHYANQLKQLDINTSKMSMEEACYGTEYLEAIDLHTSAGYPYSALGIKKRDILDPVTRDTSRMKLYMDKYGLDLPNSTYVKDELSSLDKIRKGESRLIEASSLNDPVYPRLTFGHLYEVFHANPGTVTGSAVGCNPDVFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALELVLREIGYSEEAVSLIEGINHTHHVYRNKTYCVLGGMPSGCSGTSIFNSMINNIIIRTLLIKTFKGIDLDELKMVAYGDDVLASYPFPIDCLEWGKTGKEYGLTMTPADKSPCFNEVTWENATFLKRGFLPDHQFPFLIHPTMPMREIHESIRWTKDARNTQDHVRSLCLLAWHNGKEEYEKFVSTIRSVPIGRALAIPNLENLRRNWLELF
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Organism
Human enterovirus 71 (strain USA/BrCr/1970), EV71, EV-71
Protein Classification
Enzyme
>
Transferase
Function
Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3 (By similarity). The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome (By similarity). Capsid protein VP1 mainly forms the vertices of the capsid (By similarity). Capsid protein VP1, together with VP2, interacts with host cell receptor SCARB2 to provide virion attachment to target host cells. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (PubMed:20956521, PubMed:37417384). After binding to its receptor, the capsid undergoes conformational changes (By similarity). Capsid protein VP1 N-terminus (that contains an amphipathic alpha-helix) and capsid protein VP4 are externalized (By similarity). Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm (By similarity).
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Uniprot ID
Q66478
Subcellular Location
Virion
Host cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000264 , RD
Compound ID Compound Name Compound Formula
CP0558561
1-(2-aminopyridin-4-yl)-3-[5-[4-[(E)-ethoxyiminomethyl]phenoxy]-3-methylpentyl]imidazolidin-2-one
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C23H31N5O3
 1
1
EC50 = 0.03 nM
   TI
   LI
   LO
   TS
CP0389051
4-[5-[5-[4-[(E)-ethoxyiminomethyl]phenoxy]pentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C21H29N5O4S
 1
1
EC50 = 0.9 nM
   TI
   LI
   LO
   TS
CP0391895
4-[5-[5-[[(1E)-1-ethoxyimino-2,3-dihydroinden-5-yl]oxy]pentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C23H31N5O4S
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0440878
4-[5-[5-[4-(4-chlorophenyl)phenoxy]pentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C24H27ClN4O3S
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0561761
1-[4-[6-(4-chlorophenyl)-3,4-dihydro-2H-chromen-2-yl]butyl]-3-pyridin-4-ylimidazolidin-2-one
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C27H28ClN3O2
 1
1
EC50 = 48 nM
   TI
   LI
   LO
   TS
CP0438421
1-[5-(4''-Chloro-biphenyl-4-yloxy)-pentyl]-3-pyridin-4-yl-imidazolidin-2-one
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C25H26ClN3O2
 1
1
EC50 = 91 nM
   TI
   LI
   LO
   TS
CP0391893
2-[5-[4-(4-chlorophenyl)phenoxy]pentyl]-5-pyridin-4-yl-1,2,5-thiadiazolidine 1,1-dioxide
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C24H26ClN3O3S
 1
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
CP0391894
1-[5-[4-(4-chlorophenyl)phenoxy]pentyl]-4-pyridin-4-ylpiperazin-2-one
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C26H28ClN3O2
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0566814
4-[5-[5-[[(5E)-5-ethoxyimino-7,8-dihydro-6H-naphthalen-2-yl]oxy]pentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C24H33N5O4S
 1
1
EC50 = 309 nM
   TI
   LI
   LO
   TS
CP0559446
4-[5-[5-[(3-ethyl-1,2-benzoxazol-6-yl)oxy]pentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C21H27N5O4S
 1
1
EC50 = 352 nM
   TI
   LI
   LO
   TS
CP0444349
1-[4-[6-(4-chlorophenyl)-4-oxo-2,3-dihydrochromen-2-yl]butyl]-3-pyridin-4-ylimidazolidin-2-one
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C27H26ClN3O3
 1
1
EC50 = 540 nM
   TI
   LI
   LO
   TS
CP0566812
4-[5-[5-[4-[(E)-N-ethoxy-C-ethylcarbonimidoyl]phenoxy]pentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C23H33N5O4S
 1
1
EC50 = 554 nM
   TI
   LI
   LO
   TS
CP0560048
4-[5-[5-[4-[(E)-N-ethoxy-C-methylcarbonimidoyl]phenoxy]pentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C22H31N5O4S
 1
1
EC50 = 600 nM
   TI
   LI
   LO
   TS
CP0521551
1-[4-[5-(4-chlorophenyl)-1-benzofuran-2-yl]butyl]-3-pyridin-4-ylimidazolidin-2-one
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C26H24ClN3O2
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0560049
1-[4-[5-(4-chlorophenyl)-1,3-benzoxazol-2-yl]butyl]-3-pyridin-4-ylimidazolidin-2-one
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C25H23ClN4O2
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0521550
4-[5-[4-(4-chlorophenyl)phenoxy]pentyl]-1-pyridin-4-ylpiperazin-2-one
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C26H28ClN3O2
 1
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0389050
1-[5-[4-(4-chlorophenyl)phenoxy]pentyl]-3-pyridin-4-ylimidazolidine-2-thione
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C25H26ClN3OS
 1
1
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0014362
Adenosine receptor agonist, 16
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C8H12N4O5
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0140897
3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
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C18H18F3N3O3
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0427274
4-[5-[5-(1-ethylindol-5-yl)oxypentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C22H29N5O3S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0541168
4-[5-[5-(1-ethylindazol-5-yl)oxypentyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]pyridin-2-amine
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C21H28N6O3S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0558013
1-[5-[4-(4-chlorophenyl)phenoxy]pentyl]-4-pyridin-4-ylpiperazine-2,3-dione
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C26H26ClN3O3
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS