General Information of the Protein
Protein ID
PT06387
Protein Name
Solute carrier family 2, facilitated glucose transporter member 3
Secondarily
Protein Name
Glucose transporter type 3
brain
Gene Name
SLC2A3
Secondarily
Gene Name
GLUT3
Sequence
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC02 family of hexose and sugar alcohol transporters
Function
Facilitative glucose transporter (PubMed:9477959, PubMed:26176916). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916). Required for mesendoderm differentiation (By similarity).
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Uniprot ID
Primary ID:
P11169

Secondarily ID:
B2R606
D3DUU6
Q6I9U2
Q9UG15
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Ensembl ID
ENSG00000059804
HGNC ID
HGNC:11007
Subcellular Location
Cell membrane
Perikaryon
Cell projection
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000134 , DLD-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0404684
 Compound Info 
4-[4-(2-methoxyphenyl)-1,4-diazepan-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C23H24N6O
  1
1
IC50 = 8 nM
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CP0459806
 Compound Info 
4-[4-(5-fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C22H21FN6O
  1
1
IC50 = 10 nM
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CP0547702
 Compound Info 
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenoxy)-N-(tert-pentyl)acetamide
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C28H30N6O3
  1
1
IC50 = 12 nM
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CP0540741
 Compound Info 
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)phenoxy)-N-(tert-butyl)acetamide
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C28H30N6O3
  1
1
IC50 = 26 nM
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CP0540746
 Compound Info 
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)phenoxy)-N-(pentan-3-yl)acetamide
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C29H32N6O3
  1
1
IC50 = 33 nM
 Bioactivity Info 
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CP0404683
 Compound Info 
4-methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzamide
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C23H23N7O2
  1
1
IC50 = 37 nM
 Bioactivity Info 
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CP0409067
 Compound Info 
1-(2-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C22H21FN6O
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0428405
 Compound Info 
4-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C22H21FN6O
  1
1
IC50 = 40 nM
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CP0555481
 Compound Info 
1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C22H21FN6O
  1
1
IC50 = 46 nM
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CP0547697
 Compound Info 
US10729691, Example 13
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C28H28N6O3
  1
1
IC50 = 47 nM
 Bioactivity Info 
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CP0472305
 Compound Info 
4-methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile
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C23H21N7O
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0491293
 Compound Info 
N-tert-butyl-2-[3-[4-[4-(1H-pyrazol-4-yl)anilino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C28H31N7O2
  1
1
IC50 = 58 nM
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CP0434892
 Compound Info 
4-[4-(4-methoxypyridin-3-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C21H21N7O
  1
1
IC50 = 60 nM
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CP0923029
 Compound Info 
2-(4-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl)phenol
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C21H20N6O
  1
1
IC50 = 60 nM
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CP0448154
 Compound Info 
6-[4-(2-methoxyphenyl)piperazin-1-yl]-9-phenylpurine
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C22H22N6O
  1
1
IC50 = 64 nM
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CP0557070
 Compound Info 
US10729691, Example 12
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C27H26N6O3
  1
1
IC50 = 68 nM
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CP0459832
 Compound Info 
3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile
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C22H19N7
  1
1
IC50 = 69 nM
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CP0409066
 Compound Info 
4-[4-(3-methoxypyridin-2-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C21H21N7O
  1
1
IC50 = 70 nM
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CP0385986
 Compound Info 
1-(3,5-difluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C22H20F2N6O
  1
1
IC50 = 90 nM
 Bioactivity Info 
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CP0434863
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3-methylphenyl)pyrazolo[3,4-d]pyrimidine
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C23H24N6O
  1
1
IC50 = 96 nM
 Bioactivity Info 
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CP0559013
 Compound Info 
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenoxy)-N-isopropylacetamide
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C26H26N6O3
  1
1
IC50 = 97 nM
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CP0391133
 Compound Info 
1-(2-methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C23H24N6O2
  1
1
IC50 = 110 nM
 Bioactivity Info 
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CP0385987
 Compound Info 
1-(3-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C22H21FN6O
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0391141
 Compound Info 
1-cyclopentyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C21H26N6O
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0448159
 Compound Info 
4-[4-(2-methoxyphenyl)-3-methylpiperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C23H24N6O
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0559745
 Compound Info 
N-pentan-3-yl-2-[3-[4-[4-(1H-pyrazol-4-yl)anilino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C29H33N7O2
  1
1
IC50 = 121 nM
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CP0416510
 Compound Info 
N-cyclopentyl-2-[3-[4-[4-(1H-pyrazol-4-yl)anilino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C29H31N7O2
  1
1
IC50 = 138 nM
 Bioactivity Info 
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CP0914119
 Compound Info 
2-(3-(4-((4-(1H-Pyrazol-4-yl)phenyl)amino)-6-(tetrahydrofuran-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-(tert-butyl)acetamide
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C32H37N7O3
  1
1
IC50 = 155 nM
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CP0527208
 Compound Info 
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenoxy)-N-(2,2,2-trifluoroethyl)acetamide
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C25H21F3N6O3
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0383099
 Compound Info 
1-(3-methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C23H24N6O2
  1
1
IC50 = 170 nM
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CP0385736
 Compound Info 
1-(4-methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C23H24N6O2
  1
1
IC50 = 170 nM
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CP0448118
 Compound Info 
3-methoxy-4-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile
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C23H21N7O
  1
1
IC50 = 170 nM
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CP0437538
 Compound Info 
N-tert-butyl-2-[3-[6-(2-methoxyethyl)-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C31H37N7O3
  1
1
IC50 = 175 nM
 Bioactivity Info 
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CP0547554
 Compound Info 
2-[3-[6-cyclobutyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)acetamide
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C32H35N7O2
  1
1
IC50 = 179 nM
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CP0385735
 Compound Info 
4-[4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidin-1-yl]benzonitrile
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C23H21N7O
  1
1
IC50 = 200 nM
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CP0437537
 Compound Info 
2-[3-[6-cyclopropyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)acetamide
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C31H33N7O2
  1
1
IC50 = 211 nM
 Bioactivity Info 
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CP0878647
 Compound Info 
N-tert-butyl-2-[3-[6-(2-fluoro-1-methylethyl)-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C31H36FN7O2
  1
1
IC50 = 232 nM
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CP0545722
 Compound Info 
US10729691, Example 4
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C26H24N6O3
  1
1
IC50 = 238 nM
 Bioactivity Info 
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CP0549289
 Compound Info 
2-[3-[6-cyclobutyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-propan-2-ylacetamide
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C31H35N7O2
  1
1
IC50 = 238 nM
 Bioactivity Info 
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CP0448153
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(2-methylphenyl)pyrazolo[3,4-d]pyrimidine
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C23H24N6O
  1
1
IC50 = 250 nM
 Bioactivity Info 
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CP0873394
 Compound Info 
4-(4-(2-methoxyphenyl)piperazin-1-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine
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C22H22N6O
  1
1
IC50 = 250 nM
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CP0928864
 Compound Info 
2-(3-(4-((4-(1H-Pyrazol-4-yl)phenyl)amino)-6-(1-methoxypropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-(tert-butyl)acetamide
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C32H39N7O3
  1
1
IC50 = 275 nM
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CP0549291
 Compound Info 
N-tert-butyl-2-[3-[6-cyclobutyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C32H37N7O2
  1
1
IC50 = 287 nM
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CP0437535
 Compound Info 
N-propyl-2-[3-[4-[4-(1H-pyrazol-4-yl)anilino]-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]phenoxy]acetamide
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C26H26N6O3
  1
1
IC50 = 298 nM
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CP0512485
 Compound Info 
4-[4-(3-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C22H22N6O
  1
1
IC50 = 320 nM
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CP0551780
 Compound Info 
1-(5-fluoro-2-methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C23H23FN6O2
  1
1
IC50 = 320 nM
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CP0548586
 Compound Info 
N-phenyl-2-[3-[4-[4-(1H-pyrazol-4-yl)anilino]-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]phenoxy]acetamide
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C29H24N6O3
  1
1
IC50 = 325 nM
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CP0549417
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(6-methoxypyridin-3-yl)pyrazolo[3,4-d]pyrimidine
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C22H23N7O2
  1
1
IC50 = 340 nM
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CP0391140
 Compound Info 
3-[4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidin-1-yl]benzonitrile
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C23H21N7O
  1
1
IC50 = 350 nM
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CP0437536
 Compound Info 
N-propan-2-yl-2-[3-[4-[4-(1H-pyrazol-4-yl)anilino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C27H29N7O2
  1
1
IC50 = 365 nM
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CP0527209
 Compound Info 
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-(tert-butyl)acetamide
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C29H33N7O2
  1
1
IC50 = 368 nM
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CP0416582
 Compound Info 
N-cyclopentyl-2-[3-[6-methyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C30H33N7O2
  1
1
IC50 = 391 nM
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CP0416584
 Compound Info 
N-(2-methylbutan-2-yl)-2-[3-[6-methyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C30H35N7O2
  1
1
IC50 = 391 nM
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CP0547556
 Compound Info 
2-[3-[6-(1-methylcyclopropyl)-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-propan-2-ylacetamide
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C31H35N7O2
  1
1
IC50 = 392 nM
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CP0540744
 Compound Info 
N-tert-butyl-2-[3-[6-propan-2-yl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C31H37N7O2
  1
1
IC50 = 412 nM
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CP0955355
 Compound Info 
7-(4-(2-methoxyphenyl)piperazin-1-yl)-3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine
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C21H21N7O
  1
1
IC50 = 430 nM
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CP0512399
 Compound Info 
4-[4-(2-methoxyphenyl)-2-methylpiperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C23H24N6O
  1
1
IC50 = 480 nM
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CP0479084
 Compound Info 
N-tert-butyl-2-[3-[6-ethyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C30H35N7O2
  1
1
IC50 = 482 nM
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CP0448114
 Compound Info 
4-[4-(3-fluorophenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C21H19FN6
  1
1
IC50 = 540 nM
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CP0468017
 Compound Info 
2-methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile
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C23H21N7O
  1
1
IC50 = 540 nM
 Bioactivity Info 
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CP0437541
 Compound Info 
N-cyclopentyl-2-[3-[6-propan-2-yl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C32H37N7O2
  1
1
IC50 = 548 nM
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CP0437542
 Compound Info 
2-[3-[6-cyclopropyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-propan-2-ylacetamide
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C30H33N7O2
  1
1
IC50 = 548 nM
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CP0540742
 Compound Info 
N-cyclobutyl-2-[3-[6-methyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C29H31N7O2
  1
1
IC50 = 566 nM
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CP0547555
 Compound Info 
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-(pentan-3-yl)acetamide
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C30H35N7O2
  1
1
IC50 = 584 nM
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CP0533426
 Compound Info 
N-propan-2-yl-2-[3-[6-propan-2-yl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C30H35N7O2
  1
1
IC50 = 619 nM
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CP0448116
 Compound Info 
6-[4-(2-methoxyphenyl)piperazin-1-yl]-9-phenyl-7H-purin-8-one
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C22H22N6O2
  1
1
IC50 = 630 nM
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CP0434860
 Compound Info 
4-[4-(2-methoxypyridin-3-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C21H21N7O
  1
1
IC50 = 680 nM
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CP0505220
 Compound Info 
4-[4-(2-fluorophenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C21H19FN6
  1
1
IC50 = 680 nM
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CP0416509
 Compound Info 
N,N-diethyl-2-[3-[4-[4-(1H-pyrazol-4-yl)anilino]-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]phenoxy]acetamide
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C27H28N6O3
  1
1
IC50 = 686 nM
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CP0533427
 Compound Info 
N-(2-methylpropyl)-2-[3-[6-propan-2-yl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C31H37N7O2
  1
1
IC50 = 802 nM
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CP0416585
 Compound Info 
2-[3-[6-ethyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-propan-2-ylacetamide
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C29H33N7O2
  1
1
IC50 = 846 nM
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CP0437540
 Compound Info 
N-(2-methylpropyl)-2-[3-[6-methyl-4-[4-(1H-pyrazol-4-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]phenoxy]acetamide
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C29H33N7O2
  1
1
IC50 = 846 nM
 Bioactivity Info 
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CP0517585
 Compound Info 
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-isopropylacetamide
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C28H31N7O2
  1
1
IC50 = 867 nM
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CP0385737
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-pyridin-2-ylpyrazolo[3,4-d]pyrimidine
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C21H21N7O
  1
1
IC50 = 940 nM
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CP0498025
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(1-phenylethyl)pyrazolo[3,4-d]pyrimidine
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C24H26N6O
  1
1
IC50 = 950 nM
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CP0391142
 Compound Info 
4-[1-(2-methoxyphenyl)piperidin-4-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C23H23N5O
  1
1
IC50 = 1200 nM
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CP0526324
 Compound Info 
2-[3-[4-[4-(1H-pyrazol-4-yl)anilino]-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]phenoxy]-1-pyrrolidin-1-ylethanone
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C27H26N6O3
  1
1
IC50 = 1414 nM
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CP0385738
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-pyridin-3-ylpyrazolo[3,4-d]pyrimidine
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C21H21N7O
  1
1
IC50 = 1500 nM
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CP0469716
 Compound Info 
4-[4-(3-methoxypyridin-4-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C21H21N7O
  1
1
IC50 = 1510 nM
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CP0434858
 Compound Info 
4-[4-(2-fluoro-6-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C22H21FN6O
  1
1
IC50 = 1600 nM
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CP0462583
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-pyridin-4-ylpyrazolo[3,4-d]pyrimidine
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C21H21N7O
  1
1
IC50 = 1600 nM
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CP0512486
 Compound Info 
4-[4-(4-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C22H22N6O
  1
1
IC50 = 1770 nM
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CP0391132
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[4,3-c]pyridine
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C23H23N5O
  1
1
IC50 = 2000 nM
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CP0383100
 Compound Info 
2-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile
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C22H19N7
  1
1
IC50 = 2050 nM
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CP0474180
 Compound Info 
4-[6-(2-methoxyphenyl)-2,6-diazaspiro[3.3]heptan-2-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C23H22N6O
  1
1
IC50 = 2200 nM
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CP0352103
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine
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C23H24N6O
  1
1
IC50 = 3000 nM
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CP0551779
 Compound Info 
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-b]pyridine
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C23H23N5O
  1
1
IC50 = 4000 nM
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CP0434862
 Compound Info 
4-[(1S,4S)-5-(2-methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C23H22N6O
  1
1
IC50 = 4100 nM
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CP0031042
 Compound Info 
4-N-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide
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C24H16F4N6O2
  1
1
IC50 = 4809 nM
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CP0391131
 Compound Info 
1-phenyl-4-[4-[2-(trifluoromethoxy)phenyl]piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C22H19F3N6O
  1
1
IC50 > 10000 nM
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CP0448117
 Compound Info 
1-phenyl-4-[4-[2-(trifluoromethyl)phenyl]piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
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C22H19F3N6
  1
1
IC50 > 10000 nM
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CP0448119
 Compound Info 
2-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]cyclohexan-1-ol
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C21H26N6O
  1
1
IC50 > 10000 nM
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CP0448158
 Compound Info 
4-[4-(3-fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C22H21FN6O
  1
1
IC50 = 10000 nM
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CP0455456
 Compound Info 
4-[(1R,4R)-5-(2-methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C23H22N6O
  1
1
IC50 > 10000 nM
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CP0474194
 Compound Info 
4-[4-(2-methoxyphenyl)piperidin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine
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C23H23N5O
  1
1
IC50 > 10000 nM
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CP0885450
 Compound Info 
4-(4-(2-methoxyphenyl)piperazin-1-yl)-7-phenyl-7H-pyrazolo[3,4-d][1,2,3]triazine
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C21H21N7O
  1
1
IC50 > 10000 nM
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Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0031042
 Compound Info 
4-N-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide
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C24H16F4N6O2
  1
1 IC50 ~ 1600 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT07556 Solute carrier family 2, facilitated glucose transporter member 14 Homo sapiens, Human
 Protein Info