General Information of the Protein
Protein ID
PT06362
Protein Name
Cyclic AMP-responsive element-binding protein 1
Gene Name
CREB1
Sequence
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
Function
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).
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Uniprot ID
Primary ID:
P16220

Secondarily ID:
P21934
Q6V963
Q9UMA7
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Ensembl ID
ENSG00000118260
HGNC ID
HGNC:2345
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0845163
 Compound Info 
5,7-Dihydroxy-2-phenyl-6-propoxy-chromen-4-one
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C18H16O5
  1
1
AC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0304396
 Compound Info 
OROXYLIN A
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C16H12O5
  1
1
AC50 = 2200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0850223
 Compound Info 
6-Benzyloxy-5,7-dihydroxy-2-phenyl-chromen-4-one
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C22H16O5
  1
1
AC50 = 4300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0850225
 Compound Info 
6-Ethoxy-5,7-dihydroxy-2-phenyl-chromen-4-one
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C17H14O5
  1
1
AC50 = 8200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0027482
 Compound Info 
5,6,7-Trihydroxyflavone
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C15H10O5
  1
1
AC50 = 13500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0845162
 Compound Info 
Acetic acid 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromen-6-yl ester
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C17H12O6
  2
1
AC50 = 13900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
AC50 = 38300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Cyclic AMP-responsive element-binding protein (CREB1) )
Target Type Literature-reported Target