General Information of the Protein
Protein ID
PT06327
Protein Name
Sodium-dependent phosphate transport protein 2B
Secondarily
Protein Name
Na(+)-dependent phosphate cotransporter 2B
NaPi3b
Sodium/phosphate cotransporter 2B
Solute carrier family 34 member 2
Gene Name
SLC34A2
Sequence
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC34 family of sodium phosphate co-transporters
Function
Involved in actively transporting phosphate into cells via Na(+) cotransport.
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Uniprot ID
Primary ID:
O95436

Secondarily ID:
A5PL17
Q8N2K2
Q8WYA9
Q9P0V7
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Ensembl ID
ENSG00000157765
HGNC ID
HGNC:11020
Subcellular Location
Apical cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0573199
 Compound Info 
4-[ethyl-[3-[[2-[[4-[2-[4-(methylsulfamoylcarbamoyl)phenyl]ethyl]phenyl]carbamoyl]-6-piperidin-1-ylpyridin-3-yl]carbamoyl]phenyl]sulfonylamino]cyclohexane-1-carboxylic acid
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C43H51N7O9S2
  1
1
IC50 = 21 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0572734
 Compound Info 
4-[2-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-piperidin-1-ylpyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C46H56N6O7
  1
1
IC50 = 36 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0550252
 Compound Info 
4-[3-[4-[[2-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]propyl]benzoic acid
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C45H51N5O7
  1
1
IC50 = 71 nM
 Bioactivity Info 
   TI
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CP0577666
 Compound Info 
4-[2-[4-[[3-[[3-[(4-carboxycyclohexyl)-ethylsulfamoyl]benzoyl]amino]-6-piperidin-1-ylpyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C42H47N5O8S
  1
1
IC50 = 77 nM
 Bioactivity Info 
   TI
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CP0579870
 Compound Info 
4-[3-[4-[[2-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-heptan-4-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]propyl]benzoic acid;hydrochloride
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C47H56ClN5O7
  1
1
IC50 = 78 nM
 Bioactivity Info 
   TI
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CP0572733
 Compound Info 
4-[2-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-methoxypyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C42H49N5O8
  1
1
IC50 = 107 nM
 Bioactivity Info 
   TI
   LI
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CP0577078
 Compound Info 
4-[2-[4-[[3-[[3-[ethyl-[4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethylcarbamoyl]cyclohexyl]sulfamoyl]benzoyl]amino]-6-piperidin-1-ylpyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C50H64N6O11S
  1
1
IC50 = 141 nM
 Bioactivity Info 
   TI
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CP0577667
 Compound Info 
4-[2-[4-[[3-[[3-[ethyl-[4-(methylsulfamoylcarbamoyl)cyclohexyl]sulfamoyl]benzoyl]amino]-6-piperidin-1-ylpyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C43H51N7O9S2
  1
1
IC50 = 147 nM
 Bioactivity Info 
   TI
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   LO
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CP0578367
 Compound Info 
4-[2-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-(dimethylamino)pyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C43H52N6O7
  1
1
IC50 = 161 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0577236
 Compound Info 
4-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-piperidin-1-ylpyridine-2-carbonyl]amino]phenoxy]benzoic acid
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C44H52N6O8
  1
1
IC50 = 162 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0574536
 Compound Info 
4-[3-[4-[[2-[[3-[[2-[[4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethylamino]-4-oxobutanoyl]-methylamino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]propyl]benzoic acid
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C53H68N6O10
  1
1
IC50 = 166 nM
 Bioactivity Info 
   TI
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CP0578502
 Compound Info 
4-[methyl-[2-[[3-[[2-[[4-[2-[4-(methylsulfamoylcarbamoyl)phenyl]ethyl]phenyl]carbamoyl]-6-piperidin-1-ylpyridin-3-yl]carbamoyl]phenyl]methyl-pentan-3-ylamino]ethyl]amino]-4-oxobutanoic acid
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C47H60N8O8S
  1
1
IC50 = 192 nM
 Bioactivity Info 
   TI
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CP0580149
 Compound Info 
4-[2-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-(2-methoxyethoxy)pyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C44H53N5O9
  1
1
IC50 = 201 nM
 Bioactivity Info 
   TI
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CP0573196
 Compound Info 
4-[2-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-morpholin-4-ylpyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C45H54N6O8
  1
1
IC50 = 205 nM
 Bioactivity Info 
   TI
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CP0577077
 Compound Info 
4-[methyl-[2-[[3-[[2-[[4-[2-[4-(methylsulfonylcarbamoyl)phenyl]ethyl]phenyl]carbamoyl]-6-piperidin-1-ylpyridin-3-yl]carbamoyl]phenyl]methyl-pentan-3-ylamino]ethyl]amino]-4-oxobutanoic acid
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C47H59N7O8S
  1
1
IC50 = 237 nM
 Bioactivity Info 
   TI
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CP0970487
 Compound Info 
4-[3-(4-{[2-(3-{[(1r,4r)-4-Carboxycyclohexyl](ethyl)sulfamoyl}benzamido)-1H-indole-3-carbonyl]amino}phenyl)propyl]benzoic acid
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C41H42N4O8S
  1
1
IC50 = 257 nM
 Bioactivity Info 
   TI
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CP0572634
 Compound Info 
4-[3-[4-[[2-[[3-[[2-[carboxymethoxycarbonylsulfamoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]propyl]benzoic acid
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C44H50N6O10S
  1
1
IC50 = 267 nM
 Bioactivity Info 
   TI
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CP0573195
 Compound Info 
4-[2-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-chloropyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C41H46ClN5O7
  1
1
IC50 = 271 nM
 Bioactivity Info 
   TI
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CP0577611
 Compound Info 
4-[3-[4-[[2-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-propan-2-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]propyl]benzoic acid
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C43H47N5O7
  1
1
IC50 = 356 nM
 Bioactivity Info 
   TI
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CP0551939
 Compound Info 
4-[3-[4-[[2-[[3-[[2-[carboxymethylcarbamoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]propyl]benzoic acid
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C44H50N6O7
  1
1
IC50 = 369 nM
 Bioactivity Info 
   TI
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CP0569613
 Compound Info 
4-[3-[4-[[2-[[3-[[2-[[2-[(5-carbamoyl-1H-pyrrol-3-yl)sulfonylamino]acetyl]-methylamino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]propyl]benzoic acid
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C48H54N8O8S
  1
1
IC50 = 401 nM
 Bioactivity Info 
   TI
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CP0969408
 Compound Info 
4-[3-(4-{[2-(3-{[(2-{[(2,5-Dioxohexahydroimidazo[4,5-d]imidazol-1(2H)-yl)acetyl](methyl)amino}ethyl)(pentan-3-yl)amino]methyl}benzamido)-1H-indole-3-carbonyl]amino}phenyl)propyl]benzoic acid
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C47H53N9O7
  1
1
IC50 = 401 nM
 Bioactivity Info 
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CP0577505
 Compound Info 
4-[[4-[[2-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]methyl]benzoic acid
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C43H47N5O7
  1
1
IC50 = 448 nM
 Bioactivity Info 
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CP0570247
 Compound Info 
4-[3-[4-[[2-[[3-[[2-[[4-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethylamino]-4-oxobutanoyl]-methylamino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-1H-indole-3-carbonyl]amino]phenyl]propyl]benzoic acid
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C54H68N6O11
  1
1
IC50 = 535 nM
 Bioactivity Info 
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CP0570244
 Compound Info 
4-[methyl-[2-[pentan-3-yl-[[3-[[3-(phenylcarbamoyl)-1H-indol-2-yl]carbamoyl]phenyl]methyl]amino]ethyl]amino]-4-oxobutanoic acid
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C35H41N5O5
  1
1
IC50 = 538 nM
 Bioactivity Info 
   TI
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CP0573198
 Compound Info 
6-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-piperidin-1-ylpyridine-2-carbonyl]amino]phenoxy]pyridine-3-carboxylic acid
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C43H51N7O8
  1
1
IC50 = 715 nM
 Bioactivity Info 
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CP0572735
 Compound Info 
6-[[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-piperidin-1-ylpyridine-2-carbonyl]amino]phenoxy]methyl]pyridine-3-carboxylic acid
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C44H53N7O8
  1
1
IC50 = 744 nM
 Bioactivity Info 
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CP0966273
 Compound Info 
4-{3-[4-({2-[3-({3-[(3-Carboxypropanoyl)(methyl)amino]pyrrolidin-1-yl}methyl)benzamido]-1H-indole-3-carbonyl}amino)phenyl]propyl}benzoic acid hydrochloride
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C42H44ClN5O7
  1
1
IC50 = 1015 nM
 Bioactivity Info 
   TI
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CP0573197
 Compound Info 
4-[2-[4-[[3-[[3-[[2-[3-carboxypropanoyl(methyl)amino]ethyl-pentan-3-ylamino]methyl]benzoyl]amino]-6-(4-methylpiperazin-1-yl)pyridine-2-carbonyl]amino]phenyl]ethyl]benzoic acid
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C46H57N7O7
  1
1
IC50 = 1342 nM
 Bioactivity Info 
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CP0965430
 Compound Info 
4-{3-[4-({2-[3-({[1-(3-Carboxypropanoyl)pyrrolidin-3-yl](methyl)amino}methyl)benzamido]-1H-indole-3-carbonyl}amino)phenyl]propyl}benzoic acid hydrochloride
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C42H44ClN5O7
  1
1
IC50 = 2582 nM
 Bioactivity Info 
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Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Sodium/phosphate cotransporter 2B (SLC34A2) )
Target Type Clinical trial Target