General Information of the Protein
Protein ID
PT06283
Protein Name
Sodium-dependent proline transporter
Secondarily
Protein Name
Solute carrier family 6 member 7
Gene Name
SLC6A7
Secondarily
Gene Name
PROT
Sequence
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Brain specific sodium (and chloride)-dependent proline transporter (PubMed:7651355). Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable).
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Uniprot ID
Primary ID:
Q99884

Secondarily ID:
Q0VG81
Q52LU6
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Ensembl ID
ENSG00000011083
HGNC ID
HGNC:11054
Subcellular Location
Synaptic cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000109 , COS-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0123679
 Compound Info 
[4-(3-chlorophenyl)phenyl]-(3-pyrimidin-2-yl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone
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C23H21ClN4O
  1
1
IC50 = 18 nM
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CP0542242
 Compound Info 
[4-(4-chlorophenyl)phenyl]-[(2S)-2-methyl-4-pyrimidin-2-ylpiperazin-1-yl]methanone
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C22H21ClN4O
  1
1
IC50 = 21 nM
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CP0542240
 Compound Info 
[4-(3-chlorophenyl)phenyl]-(2,6-dimethyl-4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C23H23ClN4O
  1
1
IC50 = 24 nM
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CP0116882
 Compound Info 
[4-(3-chlorophenyl)phenyl]-(8-pyrimidin-2-yl-3,8-diazabicyclo[3.2.1]octan-3-yl)methanone
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C23H21ClN4O
  1
1
IC50 = 27 nM
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CP0508749
 Compound Info 
[4-(4-methylthiophen-2-yl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C20H20N4OS
  1
1
IC50 = 34 nM
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CP0548563
 Compound Info 
[4-(4-methylphenyl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C22H22N4O
  1
1
IC50 = 34 nM
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CP0415510
 Compound Info 
[4-(3-chlorophenyl)phenyl]-(2-pyrimidin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)methanone
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C23H21ClN4O
  1
1
IC50 = 36 nM
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CP0572744
 Compound Info 
[4-(3-chlorophenyl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C21H19ClN4O
  1
1
IC50 = 36 nM
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CP0550916
 Compound Info 
[4-(4-chlorophenyl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C21H19ClN4O
  1
1
IC50 = 52 nM
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CP0400348
 Compound Info 
[4-(3-chlorophenyl)phenyl]-(2,2-dimethyl-4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C23H23ClN4O
  1
1
IC50 = 53 nM
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CP0494522
 Compound Info 
[4-(4-chlorophenyl)phenyl]-[(2R)-2-methyl-4-pyrimidin-2-ylpiperazin-1-yl]methanone
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C22H21ClN4O
  1
1
IC50 = 57 nM
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CP0399533
 Compound Info 
[4-(5-methylthiophen-2-yl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C20H20N4OS
  1
1
IC50 = 61 nM
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CP0546437
 Compound Info 
(4-pyrimidin-2-ylpiperazin-1-yl)-[4-[3-(trifluoromethyl)phenyl]phenyl]methanone
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C22H19F3N4O
  1
1
IC50 = 71 nM
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CP0487930
 Compound Info 
(4-pyrimidin-2-ylpiperazin-1-yl)-[4-[3-(trifluoromethoxy)phenyl]phenyl]methanone
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C22H19F3N4O2
  1
1
IC50 = 73 nM
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CP0487932
 Compound Info 
[4-(3-chlorophenyl)phenyl]-[2-(hydroxymethyl)-4-pyrimidin-2-ylpiperazin-1-yl]methanone
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C22H21ClN4O2
  1
1
IC50 = 76 nM
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CP0550915
 Compound Info 
(4-pyrimidin-2-ylpiperazin-1-yl)-[4-[4-(trifluoromethyl)phenyl]phenyl]methanone
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C22H19F3N4O
  1
1
IC50 = 76 nM
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CP0542237
 Compound Info 
[4-(4-ethylphenyl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C23H24N4O
  1
1
IC50 = 77 nM
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CP0547674
 Compound Info 
[4-(3-chlorophenyl)phenyl]-(4-pyrimidin-2-yl-1,4-diazepan-1-yl)methanone
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C22H21ClN4O
  1
1
IC50 = 89 nM
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CP0542241
 Compound Info 
1-[4-(3-chlorophenyl)benzoyl]-4-pyrimidin-2-ylpiperazine-2-carboxylic acid
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C22H19ClN4O3
  1
1
IC50 = 128 nM
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CP0415509
 Compound Info 
(4-phenylphenyl)-[4-(1,3-thiazol-2-yl)piperazin-1-yl]methanone
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C20H19N3OS
  1
1
IC50 = 146 nM
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CP0533190
 Compound Info 
[4-(5-chlorothiophen-2-yl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C19H17ClN4OS
  1
1
IC50 = 150 nM
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CP0542239
 Compound Info 
(4-phenylphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
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C22H21N3O
  1
1
IC50 = 160 nM
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CP0546436
 Compound Info 
3-[4-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]benzonitrile
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C22H19N5O
  1
1
IC50 = 190 nM
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CP0555111
 Compound Info 
4-[4-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]benzonitrile
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C22H19N5O
  1
1
IC50 = 190 nM
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CP0555110
 Compound Info 
[4-(4-methoxyphenyl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C22H22N4O2
  1
1
IC50 = 230 nM
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CP0556363
 Compound Info 
[4-(4-fluorophenyl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C21H19FN4O
  1
1
IC50 = 260 nM
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CP0474335
 Compound Info 
[4-(4-methylpyrimidin-2-yl)piperazin-1-yl]-(4-phenylphenyl)methanone
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C22H22N4O
  1
1
IC50 = 270 nM
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CP0482010
 Compound Info 
(4-phenylmethoxyphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C22H22N4O2
  1
1
IC50 = 270 nM
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CP0542238
 Compound Info 
(4-phenylphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C21H20N4O
  1
1
IC50 = 280 nM
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CP0548564
 Compound Info 
1-[4-(3-chlorophenyl)benzoyl]-N,N-dimethyl-4-pyrimidin-2-ylpiperazine-2-carboxamide
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C24H24ClN5O2
  1
1
IC50 = 392 nM
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CP0494519
 Compound Info 
(3-methyl-4-pyrimidin-2-ylpiperazin-1-yl)-(4-phenylphenyl)methanone
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C22H22N4O
  1
1
IC50 = 477 nM
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CP0566884
 Compound Info 
4-(3-chlorophenyl)-N-methyl-N-[2-[methyl(pyrimidin-2-yl)amino]ethyl]benzamide
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C21H21ClN4O
  1
1
IC50 = 586 nM
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CP0474338
 Compound Info 
[4-(2-methylphenyl)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C22H22N4O
  1
1
IC50 = 653 nM
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CP0510583
 Compound Info 
(2-tert-butyl-4-pyrimidin-2-ylpiperazin-1-yl)-[4-(3-chlorophenyl)phenyl]methanone
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C25H27ClN4O
  1
1
IC50 = 700 nM
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CP0533184
 Compound Info 
[4-(benzylamino)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C22H23N5O
  1
1
IC50 = 870 nM
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CP0553540
 Compound Info 
[4-(2-phenylethoxy)phenyl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C23H24N4O2
  1
1
IC50 = 1020 nM
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CP0547673
 Compound Info 
(4-pyrimidin-2-ylpiperazin-1-yl)-[4-[2-(trifluoromethyl)phenyl]phenyl]methanone
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C22H19F3N4O
  1
1
IC50 = 1260 nM
 Bioactivity Info 
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CP0550919
 Compound Info 
(4-phenylphenyl)-(4-pyrazin-2-ylpiperazin-1-yl)methanone
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C21H20N4O
  1
1
IC50 = 1300 nM
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CP0548565
 Compound Info 
[4-(3-chlorophenyl)phenyl]-(5-pyrimidin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl)methanone
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C22H19ClN4O
  1
1
IC50 = 1340 nM
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CP0381994
 Compound Info 
(4-phenylphenyl)-(4-phenylpiperazin-1-yl)methanone
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C23H22N2O
  1
1
IC50 = 1480 nM
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CP0550918
 Compound Info 
(3-phenylphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C21H20N4O
  1
1
IC50 = 1880 nM
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CP0562183
 Compound Info 
(4-phenoxyphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C21H20N4O2
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1
IC50 = 1950 nM
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CP0480583
 Compound Info 
(4-phenylphenyl)-[4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]methanone
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C22H19F3N4O
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1
IC50 = 2180 nM
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CP0547671
 Compound Info 
(4-pyrimidin-2-ylpiperazin-1-yl)-(4-pyrrol-1-ylphenyl)methanone
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C19H19N5O
  1
1
IC50 = 2230 nM
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CP0562165
 Compound Info 
phenyl-[4-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methanone
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C22H20N4O2
  1
1
IC50 = 2700 nM
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CP0400701
 Compound Info 
[4-(4-fluorophenyl)piperazin-1-yl]-(4-phenylphenyl)methanone
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C23H21FN2O
  1
1
IC50 = 3440 nM
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CP0381991
 Compound Info 
(4-phenylphenyl)-(4-pyridazin-3-ylpiperazin-1-yl)methanone
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C21H20N4O
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1
IC50 = 5000 nM
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CP0480582
 Compound Info 
(2-phenylphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C21H20N4O
  1
1
IC50 = 6010 nM
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CP0548562
 Compound Info 
(4-cyclohexylphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C21H26N4O
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1
IC50 = 7010 nM
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CP0517053
 Compound Info 
(4-pyridin-2-ylphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C20H19N5O
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1
IC50 = 7080 nM
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CP0474336
 Compound Info 
[4-(4-chlorophenyl)piperazin-1-yl]-(4-phenylphenyl)methanone
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C23H21ClN2O
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1
IC50 > 10000 nM
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CP0474337
 Compound Info 
2-phenyl-N-[4-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]acetamide
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C23H23N5O2
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1
IC50 > 10000 nM
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CP0510582
 Compound Info 
benzyl N-[4-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]carbamate
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C23H23N5O3
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1
IC50 > 10000 nM
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CP0517052
 Compound Info 
(4-imidazol-1-ylphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
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C18H18N6O
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1
IC50 > 10000 nM
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Clinical Information about the Protein
Target 1 ( Sodium-dependent proline transporter (SLC6A7) )
Target Type Literature-reported Target