General Information of the Protein
Protein ID
PT06150
Protein Name
Vasoactive intestinal polypeptide receptor 1
Secondarily
Protein Name
Pituitary adenylate cyclase-activating polypeptide type II receptor
Gene Name
VIPR1
Sequence
MRPPSPPHVRWLCVLAGALACALRPAGSQAASPQHECEYLQLIEIQRQQCLEEAQLENETTGCSKMWDNLTCWPTTPRGQAVVLDCPLIFQLFAPIHGYNISRSCTEEGWSQLEPGPYHIACGLNDRASSLDEQQQTKFYNTVKTGYTIGYSLSLASLLVAMAILSLFRKLHCTRNYIHMHLFMSFILRATAVFIKDMALFNSGEIDHCSEASVGCKAAVVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSVFITIWTVVRIYFEDFGCWDTIINSSLWWIIKAPILLSILVNFVLFICIIRILVQKLRPPDIGKNDSSPYSRLAKSTLLLIPLFGIHYVMFAFFPDNFKAQVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWSSKSQHPWGGSNGATCSTQVSMLTRVSPSARRSSSFQAEVSLV
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family B G protein-coupled receptor
>
Peptide receptor (family B GPCR)
>
Vasoactive intestinal peptide receptor
>
Vasoactive intestinal peptide receptor
Function
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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Uniprot ID
P30083
Ensembl ID
ENSG00000114812
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000780 , RKE
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0391381
 Compound Info 
[4-tert-butyl-2-(3,4-dimethylphenyl)-6-propan-2-ylphenyl]methanol
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C22H30O
  1
1
IC50 = 81 nM
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CP0399087
 Compound Info 
[4-tert-butyl-2-(3-chlorophenyl)-6-propan-2-ylphenyl]methanol
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C20H25ClO
  1
1
IC50 = 100 nM
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CP0500255
 Compound Info 
(4-tert-butyl-2-naphthalen-2-yl-6-propan-2-ylphenyl)methanol
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C24H28O
  1
1
IC50 = 120 nM
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CP0418759
 Compound Info 
[4-tert-butyl-2-(3-methylsulfanylphenyl)-6-propan-2-ylphenyl]methanol
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C21H28OS
  1
1
IC50 = 170 nM
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CP0418939
 Compound Info 
(4-tert-butyl-2-naphthalen-1-yl-6-propan-2-ylphenyl)methanol
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C24H28O
  1
1
IC50 = 180 nM
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CP0500254
 Compound Info 
[4-tert-butyl-2-(3-methoxyphenyl)-6-propan-2-ylphenyl]methanol
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C21H28O2
  1
1
IC50 = 200 nM
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CP0497377
 Compound Info 
[4-tert-butyl-2-(3-phenylphenyl)-6-propan-2-ylphenyl]methanol
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C26H30O
  1
1
IC50 = 210 nM
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CP0456252
 Compound Info 
[4-tert-butyl-2-(3-methylphenyl)-6-propan-2-ylphenyl]methanol
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C21H28O
  1
1
IC50 = 240 nM
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CP0391991
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-phenylpropanamide
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C18H18N2OS
  1
1
IC50 = 290 nM
 Bioactivity Info 
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CP0497376
 Compound Info 
[4-tert-butyl-2-(4-chlorophenyl)-6-propan-2-ylphenyl]methanol
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C20H25ClO
  1
1
IC50 = 290 nM
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CP0400835
 Compound Info 
[4-tert-butyl-2-(4-methylphenyl)-6-propan-2-ylphenyl]methanol
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C21H28O
  1
1
IC50 = 300 nM
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CP0499549
 Compound Info 
[4-tert-butyl-2-[3-(dimethylamino)phenyl]-6-propan-2-ylphenyl]methanol
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C22H31NO
  1
1
IC50 = 310 nM
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CP0493871
 Compound Info 
(4-tert-butyl-2-phenyl-6-propan-2-ylphenyl)methanol
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C20H26O
  1
1
IC50 = 390 nM
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CP0456771
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-(4-methoxyphenyl)propanamide
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C19H20N2O2S
  1
1
IC50 = 410 nM
 Bioactivity Info 
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CP0177086
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)cyclohexanecarboxamide
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C16H20N2OS
  1
1
IC50 = 470 nM
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CP0416881
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)cyclopentanecarboxamide
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C15H18N2OS
  1
1
IC50 = 470 nM
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CP0392137
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-(4-methylphenyl)propanamide
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C19H20N2OS
  1
1
IC50 = 480 nM
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CP0399088
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-(3-methoxyphenyl)propanamide
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C19H20N2O2S
  1
1
IC50 = 610 nM
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CP0418862
 Compound Info 
[4-tert-butyl-2-(4-phenylphenyl)-6-propan-2-ylphenyl]methanol
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C26H30O
  1
1
IC50 = 680 nM
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CP0462762
 Compound Info 
[4-tert-butyl-2-(4-fluorophenyl)-6-propan-2-ylphenyl]methanol
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C20H25FO
  1
1
IC50 = 740 nM
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CP0495490
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-(3-methylphenyl)propanamide
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C19H20N2OS
  1
1
IC50 = 750 nM
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CP0463019
 Compound Info 
[4-tert-butyl-2-(2-methoxyphenyl)-6-propan-2-ylphenyl]methanol
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C21H28O2
  1
1
IC50 = 820 nM
 Bioactivity Info 
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CP0391993
 Compound Info 
3-(4-chlorophenyl)-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)propanamide
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C18H17ClN2OS
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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CP0403719
 Compound Info 
[4-tert-butyl-2-(4-methoxyphenyl)-6-propan-2-ylphenyl]methanol
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C21H28O2
  1
1
IC50 = 1300 nM
 Bioactivity Info 
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CP0166953
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-phenylacetamide
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C17H16N2OS
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0391990
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)cyclobutanecarboxamide
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C14H16N2OS
  1
1
IC50 = 1800 nM
 Bioactivity Info 
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CP0392412
 Compound Info 
2-(1-benzothiophen-2-yl)-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)acetamide
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C19H16N2OS2
  1
1
IC50 = 1900 nM
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CP0392428
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-methylbutanamide
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C14H18N2OS
  1
1
IC50 = 1900 nM
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CP0391382
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)cyclopropanecarboxamide
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C13H14N2OS
  1
1
IC50 = 2700 nM
 Bioactivity Info 
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CP0438144
 Compound Info 
[4-tert-butyl-2-(2-phenylphenyl)-6-propan-2-ylphenyl]methanol
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C26H30O
  1
1
IC50 = 3200 nM
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CP0346544
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-methylpropanamide
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C13H16N2OS
  1
1
IC50 = 3400 nM
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CP0462996
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(2,3-dihydro-1-benzofuran-2-yl)acetamide
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C19H18N2O2S
  1
1
IC50 = 3800 nM
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CP0458447
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-phenoxyacetamide
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C17H16N2O2S
  1
1
IC50 = 9100 nM
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CP0391992
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-3-(2-methylphenyl)propanamide
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C19H20N2OS
  1
1
IC50 = 11000 nM
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CP0418863
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)propanamide
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C12H14N2OS
  1
1
IC50 = 12000 nM
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CP0461693
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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C20H20N2OS
  1
1
IC50 = 12000 nM
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CP0218894
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)acetamide
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C11H12N2OS
  1
1
IC50 = 13000 nM
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CP0043252
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)benzamide
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C16H14N2OS
  1
1
IC50 = 15000 nM
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CP0462763
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2,3-dihydro-1H-indene-2-carboxamide
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C19H18N2OS
  1
1
IC50 = 17000 nM
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CP0376905
 Compound Info 
[4-tert-butyl-2-(2-methylphenyl)-6-propan-2-ylphenyl]methanol
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C21H28O
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0456253
 Compound Info 
[4-tert-butyl-2-propan-2-yl-6-[3-(trifluoromethyl)phenyl]phenyl]methanol
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C21H25F3O
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0463018
 Compound Info 
3-[5-tert-butyl-2-(hydroxymethyl)-3-propan-2-ylphenyl]benzonitrile
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C21H25NO
  1
1
IC50 > 50000 nM
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CP0495491
 Compound Info 
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(1H-indol-2-yl)acetamide
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C19H17N3OS
  1
1
IC50 = 50000 nM
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