General Information of the Protein
Protein ID
PT06111
Protein Name
Probable glucose sensor protein SLC5A4
Secondarily
Protein Name
Solute carrier family 5 member 4
Gene Name
SLC5A4
Secondarily
Gene Name
SAAT1
SGLT3
Sequence
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLKKAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC05 family of sodium-dependent glucose transporters
Function
Does not function as sodium/D-glucose symporter (PubMed:13130073, PubMed:20421923, PubMed:22766068). However, may function as a D-glucose sensor by generating a D-glucose-induced depolarization which is pH-independent, Na(+)-dependent at neutral pH and probably H(+)-dependent at acidic pH (PubMed:13130073, PubMed:22766068, PubMed:17110502, PubMed:20421923).
    Show/Hide
Uniprot ID
Primary ID:
Q9NY91

Secondarily ID:
O15279
    Show/Hide
HGNC ID
HGNC:11039
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0149289
 Compound Info 
(1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-(hydroxymethyl)-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol
   Show/Hide
C22H25ClO7
  1
1
IC50 = 0.877 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0436020
 Compound Info 
(1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)phenyl]-1-(hydroxymethyl)-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol
   Show/Hide
C21H23ClO7
  1
1
IC50 = 0.882 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0511310
 Compound Info 
(1S,2S,3S,4R,5S)-1-(Hydroxymethyl)-5-[3-(4-methoxybenzyl)-4-methylphenyl]-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol
   Show/Hide
C22H26O7
  1
1
IC50 = 1.07 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0436018
 Compound Info 
(1S,2S,3S,4R,5S)-5-[3-(4-Ethoxybenzyl)-4-methylphenyl]-1-(hydroxymethyl)-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol
   Show/Hide
C23H28O7
  1
1
IC50 = 1.11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0198642
 Compound Info 
(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol
   Show/Hide
C21H25ClO6
  1
1
IC50 = 1.35 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0165583
 Compound Info 
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methoxyphenyl)methyl]phenoxy}oxane-3,4,5-triol
   Show/Hide
C20H24O7
  1
1
IC50 = 4.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0430362
 Compound Info 
(6S,7R,8R,9S)-6-(3-(4-methoxybenzyl)-4-methylphenyl)-2,5-dioxaspiro[3.5]nonane-7,8,9-triol
   Show/Hide
C22H26O6
  1
1
IC50 = 6.98 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0498394
 Compound Info 
(1R,2S,3R,4R,6R)-4-[2-[(4-cyclopropylphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol
   Show/Hide
C23H28O5
  1
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0050531
 Compound Info 
1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one
   Show/Hide
C21H24O10
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0465997
 Compound Info 
(1R,2S,3R,4R,6R)-4-(hydroxymethyl)-6-[2-[(4-methylsulfanylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol
   Show/Hide
C21H26O5S
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0498396
 Compound Info 
(1R,2S,3R,4R,6R)-4-[2-[(4-ethylphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol
   Show/Hide
C22H28O5
  1
1
IC50 = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0499079
 Compound Info 
(1R,2S,3R,4R,6R)-4-[2-[(4-ethenylphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol
   Show/Hide
C22H26O5
  1
1
IC50 = 29 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0457422
 Compound Info 
(1R,2S,3R,4R,6R)-4-(hydroxymethyl)-6-[2-[(4-methoxyphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol
   Show/Hide
C21H26O6
  1
1
IC50 = 42 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0441334
 Compound Info 
(1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-methoxybenzyl)-phenyl]-1-(hydroxymethyl)-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol
   Show/Hide
C21H23ClO7
  1
1
IC50 = 43.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0498393
 Compound Info 
(1R,2S,3R,4R,6R)-4-(hydroxymethyl)-6-[2-[(4-methylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol
   Show/Hide
C21H26O5
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464991
 Compound Info 
(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-(pent-2-enyloxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol
   Show/Hide
C24H30O6
  1
1
IC50 = 59.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399825
 Compound Info 
(2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricyclo[14.2.2.0*3,8*]icosa-1(19),3(8),4,6,16(20),17-hexaen-5-yl)-tetrahydro-pyran-3,4,5-triol
   Show/Hide
C25H32O6
  1
1
IC50 = 81.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502635
 Compound Info 
(2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricyclo[14.2.2.0*3,8*]icosa-1(19),3(8),4,6,12,16(20),17-heptaen-5-yl)-tetrahydro-pyran-3,4,5-triol
   Show/Hide
C25H30O6
  1
1
IC50 = 89.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0511309
 Compound Info 
(1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)-phenyl]-1-(hydroxymethyl)-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol
   Show/Hide
C22H25ClO7
  1
1
IC50 = 89.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475450
 Compound Info 
(2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricyclo[15.2.2.0*3,8*]henicosa-1(20),3(8),4,6,17(21),18-hexaen-5-yl)-tetrahydro-pyran-3,4,5-triol
   Show/Hide
C26H34O6
  1
1
IC50 = 99.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0504625
 Compound Info 
(2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricyclo[15.2.2.0*3,8*]henicosa-1(20),3(8),4,6,13,17(21),18-heptaen-5-yl)-tetrahydro-pyran-3,4,5-triol
   Show/Hide
C26H32O6
  1
1
IC50 = 103 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0526904
 Compound Info 
(1R,2S,3R,4R,6R)-4-[2-[(4-ethoxyphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol
   Show/Hide
C22H28O6
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0509376
 Compound Info 
(1R,2S,3R,4R,6R)-4-(hydroxymethyl)-6-[2-[(4-propylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol
   Show/Hide
C23H30O5
  1
1
IC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0526836
 Compound Info 
(1R,2S,3R,4R,6R)-4-(hydroxymethyl)-6-[2-[[4-(trifluoromethyl)phenyl]methyl]phenoxy]cyclohexane-1,2,3-triol
   Show/Hide
C21H23F3O5
  1
1
IC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0375118
 Compound Info 
(1R,2S,3R,4R,6R)-4-[2-[(4-chlorophenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol
   Show/Hide
C20H23ClO5
  1
1
IC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0473811
 Compound Info 
(1R,2S,3R,4R,6R)-4-(hydroxymethyl)-6-[2-[(4-propan-2-ylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol
   Show/Hide
C23H30O5
  1
1
IC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0767289
 Compound Info 
Sergliflozin
   Show/Hide
C23H28O9
  1
1
IC50 = 260 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0457423
 Compound Info 
(1R,2S,3R,4R,6R)-4-(hydroxymethyl)-6-[2-[(4-hydroxyphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol
   Show/Hide
C20H24O6
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0498395
 Compound Info 
(1R,2S,3R,4R,6R)-4-[2-[(4-fluorophenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol
   Show/Hide
C20H23FO5
  1
1
IC50 = 630 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0494475
 Compound Info 
(1R,2S,3R,4R,6R)-4-(2-benzylphenoxy)-6-(hydroxymethyl)cyclohexane-1,2,3-triol
   Show/Hide
C20H24O5
  1
1
IC50 = 690 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Sodium/glucose cotransporter 2 (SLC5A4) )
Target Type Clinical trial Target
Disease 2 Target-related Diseases  2
1 Type-1/2 diabetes [ICD-11: 5A10-5A11]
2 Gout [ICD-11: FA25]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Remogliflozin etabonate
 Drug Info 
Phase 2
Type-1/2 diabetes
Discontinued Drug(s) 1 Discontinued Drug  1
1 Ponalrestat
 Drug Info 
Discontinued in Phase 3
Gout