General Information of the Protein
Protein ID
PT06082
Protein Name
Integrin alpha-3
Secondarily
Protein Name
CD49 antigen-like family member C
FRP-2
Galactoprotein B3
VLA-3 subunit alpha
Gene Name
ITGA3
Secondarily
Gene Name
MSK18
Sequence
MGPGPSRAPRAPRLMLCALALMVAAGGCVVSAFNLDTRFLVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRELAVPDGYTNRTGAVYLCPLTAHKDDCERMNITVKNDPGHHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCYVRGNDLELDSSDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKEWDLSEYSYKDPEDQGNLYIGYTMQVGSFILHPKNITIVTGAPRHRHMGAVFLLSQEAGGDLRRRQVLEGSQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAIYVFMNQAGTSFPAHPSLLLHGPSGSAFGLSVASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSKGLLRQPQQVIHGEKLGLPGLATFGYSLSGQMDVDENFYPDLLVGSLSDHIVLLRARPVINIVHKTLVPRPAVLDPALCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLRFAGSESAVFHGFFSMPEMRCQKLELLLMDNLRDKLRPIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALENHTEVQFQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQYSRDVRKLLLSINVTNTRTSERSGEDAHEALLTLVVPPALLLSSVRPPGACQANETIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYEFQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEITVHGNGSWPCRPPGDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSETVLTCATGRAHCVWLECPIPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSIPTINMENKTTWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFKRARTRALYEAKRQKAEMKSQPSETERLTDDY
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
    Show/Hide
Uniprot ID
Primary ID:
P26006

Secondarily ID:
A7E246
B7ZM80
B9EGQ1
D3DTX4
D3DTX5
    Show/Hide
Ensembl ID
ENSG00000005884
HGNC ID
HGNC:6139
Subcellular Location
Cell membrane
Cell membrane
Cell projection
Invadopodium membrane
Cell projection
Filopodium membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000111 , MDA-MB-231
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0908229
 Compound Info 
2-((3S,6R,11R,14R,20S,28aS)-11-amino-3-(2-amino-2-oxoethyl)-6-carbamoyl-27-hydroxy-20-(4-hydroxy-3-nitrobenzyl)-1,4,12,15,18,21,24-heptaoxohexacosahydropyrrolo[2,1-j][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosin-14-yl)acetic acid
   Show/Hide
C32H43N11O15S2
  1
1
IC50 = 57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0891937
 Compound Info 
2-((3S,6R,11R,14R,20S,28aS)-11-amino-6-carbamoyl-27-hydroxy-20-(4-hydroxy-3-nitrobenzyl)-3-((R)-1-hydroxyethyl)-1,4,12,15,18,21,24-heptaoxohexacosahydropyrrolo[2,1-j][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosin-14-yl)acetic acid
   Show/Hide
C32H44N10O15S2
  1
1
IC50 = 68 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0891938
 Compound Info 
2-((3S,6R,11R,14R,20S,28aS)-11-amino-6-carbamoyl-27-hydroxy-20-(4-hydroxy-3-nitrobenzyl)-3-(2-hydroxyethyl)-1,4,12,15,18,21,24-heptaoxohexacosahydropyrrolo[2,1-j][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosin-14-yl)acetic acid
   Show/Hide
C32H44N10O15S2
  1
1
IC50 = 190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0851243
 Compound Info 
2-((3S,6R,11R,14R,20S,28aS)-11-amino-6-carbamoyl-20-(3-chlorobenzyl)-27-hydroxy-3-((R)-1-hydroxyethyl)-1,4,12,15,18,21,24-heptaoxohexacosahydropyrrolo[2,1-j][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosin-14-yl)acetic acid
   Show/Hide
C32H44ClN9O12S2
  1
1
IC50 = 220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0373938
 Compound Info 
2-((3S,6R,11R,14R,20S,28aS)-11-amino-6-carbamoyl-20-(cyclohexylmethyl)-3-methyl-1,4,12,15,18,21,24-heptaoxohexacosahydropyrrolo[2,1-j][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosin-14-yl)acetic acid
   Show/Hide
C31H49N9O10S2
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0890954
 Compound Info 
2-((3S,6R,11R,14R,20S,28aS)-11-amino-6-carbamoyl-20-(cyclohexylmethyl)-27-hydroxy-1,4,12,15,18,21,24-heptaoxo-3-phenethylhexacosahydropyrrolo[2,1-j][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosin-14-yl)acetic acid
   Show/Hide
C38H55N9O11S2
  1
1
IC50 = 340 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0635703
 Compound Info 
2-((3S,6R,11R,14R,20S,28aS)-11-amino-3-(2-amino-2-oxoethyl)-6-carbamoyl-27-hydroxy-20-isobutyl-1,4,12,15,18,21,24-heptaoxohexacosahydropyrrolo[2,1-j][1,2,5,8,11,14,17,20,23]dithiaheptaazacyclohexacosin-14-yl)acetic acid
   Show/Hide
C29H46N10O12S2
  2
1
IC50 = 550 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Kd = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS