Protein Information

General Information of the Protein

Protein ID	PT06074
Protein Name	Glucagon receptor
Gene Name	GCGR
Sequence	MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT Show/Hide
Organism	Mus musculus, Mouse
Protein Classification	Membrane receptor > Family B G protein-coupled receptor > Peptide receptor (family B GPCR) > Glucagon-like receptor > Glucagon receptor
Function	G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. Show/Hide
Uniprot ID	Primary ID: Q61606 Secondarily ID: Q63960 Q8K0B5 Show/Hide
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0222548 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-propoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H21ClN2O	2
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
2	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0039137 Compound Info	4-[3-(5-Bromo-2-propoxy-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H20BrClN2O	2
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
2	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0502906 Compound Info	4-[3-(4-Bromo-2-propoxy-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H20BrClN2O	2
1	IC50 = 49 nM Bioactivity Info	TI LI LO TS
2	IC50 = 830 nM Bioactivity Info	TI LI LO TS
CP0380783 Compound Info	4-[5-(4-Chloro-phenyl)-3-(5-chloro-2-propoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H20Cl2N2O	2
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0063780 Compound Info	4-[5-(4-Chloro-phenyl)-3-isopropyl-1H-pyrrol-2-yl]-pyridine Show/Hide	C18H17ClN2	2
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0245884 Compound Info	4-[5-(4-Chloro-phenyl)-3-cyclohexyl-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H21ClN2	2
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
2	IC50 > 3000 nM Bioactivity Info	TI LI LO TS
CP0376681 Compound Info	4-[3-(2-Butoxy-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C25H23ClN2O	2
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0120350 Compound Info	3-[[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acid Show/Hide	C32H27Cl2N3O4	1
1	IC50 = 122 nM Bioactivity Info	TI LI LO TS
CP0222546 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-isobutoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C25H23ClN2O	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0096778 Compound Info	4-[5-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14ClFN2	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0202930 Compound Info	4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14Cl2N2	2
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
2	IC50 = 42000 nM Bioactivity Info	TI LI LO TS
CP0112393 Compound Info	4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]-benzonitrile Show/Hide	C22H14FN3	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0222549 Compound Info	4-[3-(3-Bromo-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14BrClN2	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0310029 Compound Info	4-[5-(4-Chloro-phenyl)-3-(4-methoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C22H17ClN2O	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0222547 Compound Info	4-[3-(2-Allyloxy-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H19ClN2O	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0063255 Compound Info	4-[5-(2,4-Dichloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H13Cl2FN2	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0147411 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-hexyloxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C27H27ClN2O	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0280722 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C23H19ClN2O	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0115930 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-methoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C22H17ClN2O	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0222552 Compound Info	4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14F2N2	2
1	IC50 = 430 nM Bioactivity Info	TI LI LO TS
2	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0384133 Compound Info	2-[5-(4-chlorophenyl)-2-pyridin-4-yl-1H-pyrrol-3-yl]-N-propylaniline Show/Hide	C24H22ClN3	2
1	IC50 = 440 nM Bioactivity Info	TI LI LO TS
2	IC50 > 3000 nM Bioactivity Info	TI LI LO TS
CP0313977 Compound Info	4-[5-(3-Chloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H14ClFN2	1
1	IC50 = 460 nM Bioactivity Info	TI LI LO TS
CP0091849 Compound Info	5-(4-Chloro-phenyl)-2-pyridin-4-yl-1H-pyrrole-3-carboxylic acid ethyl ester Show/Hide	C18H15ClN2O2	2
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
2	IC50 > 3000 nM Bioactivity Info	TI LI LO TS
CP0375132 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2,6-dipropoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C27H27ClN2O2	2
1	IC50 = 670 nM Bioactivity Info	TI LI LO TS
2	IC50 > 3000 nM Bioactivity Info	TI LI LO TS
CP0101836 Compound Info	4-[5-(4-Chloro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C15H11ClN2	2
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
2	IC50 > 3000 nM Bioactivity Info	TI LI LO TS
CP0306397 Compound Info	4-[5-(4-Chloro-phenyl)-3-(2-isopropoxy-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C24H21ClN2O	2
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
2	IC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0509122 Compound Info	5-(4-Chloro-phenyl)-2-pyridin-4-yl-1H-pyrrole-3-carboxylic acid benzyl ester Show/Hide	C23H17ClN2O2	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0337062 Compound Info	4-[3-(4-Fluoro-phenyl)-5-phenyl-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H15FN2	1
1	IC50 = 2700 nM Bioactivity Info	TI LI LO TS
CP0182277 Compound Info	4-[5-Cyclohexyl-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine Show/Hide	C21H21FN2	1
1	IC50 > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT01725	Glucagon receptor	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han