General Information of the Protein
Protein ID
PT06071
Protein Name
Sodium- and chloride-dependent glycine transporter 2
Secondarily
Protein Name
Solute carrier family 6 member 5
Gene Name
SLC6A5
Secondarily
Gene Name
Glyt2
Sequence
MDCSAPKEMNKPPTNILEATVPGHRDSPRAPRTSPEQDLPAAAPAAAVQPPRVPRSASTGAQTFQSADARACEAQRPGVGFCKLSSPQAQATSAALRDLSEGHSAQANPPSGAAGAGNALHCKIPALRGPEEDENVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Sodium- and chloride-dependent glycine transporter (PubMed:8226790, PubMed:25480793). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:8226790). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:8226790).
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Uniprot ID
Primary ID:
P58295

Secondarily ID:
F1LNM6
Q6QDB3
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000049 , C6
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0410012
 Compound Info 
5-Biphenyl-4-yl-4-(2-fluorophenyl)-N-methyl-4H-1,2,4-triazol-3-amine
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C21H17FN4
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0373521
 Compound Info 
3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-triazole
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C22H18FN3
  1
1
IC50 = 230 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379616
 Compound Info 
2-(3-Biphenyl-4-yl-5-methyl-4H-1,2,4-triazole-4-yl)benzonitrile
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C22H16N4
  1
1
IC50 = 260 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379733
 Compound Info 
3-Biphenyl-4-yl-4-(2-chlorophenyl)-5-methyl-4H-1,2,4-triazole
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C21H16ClN3
  1
1
IC50 = 280 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379732
 Compound Info 
3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole
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C21H16FN3
  1
1
IC50 = 340 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0425664
 Compound Info 
3-Biphenyl-4-yl-5-methyl-4-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
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C22H16F3N3
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0500543
 Compound Info 
2-(3-(biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-yl)phenol
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C21H17N3O
  1
1
IC50 = 680 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0425665
 Compound Info 
3-Biphenyl-4-yl-5-methyl-4-(2-methylphenyl)-4H-1,2,4-triazole
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C22H19N3
  1
1
IC50 = 780 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0511752
 Compound Info 
3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methoxy-4H-1,2,4-triazole
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C21H16FN3O
  1
1
IC50 = 990 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0389819
 Compound Info 
3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazole
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C21H17N3
  1
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0402966
 Compound Info 
3-Biphenyl-4-yl-4-(2-methoxy-phenyl)-5-methyl-4H-[1,2,4]triazole
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C22H19N3O
  1
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0051811
 Compound Info 
3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole
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C23H20FN3
  1
1
IC50 = 3300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS