General Information of the Protein
Protein ID
PT06059
Protein Name
B1 bradykinin receptor
Gene Name
BDKRB1
Sequence
MASWPPLQLQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICSFGLLGNLFVLLVFLLPRRRLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGIIKANLFISIFLVVAISQDRYCVLVHPMASRRRQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILAFLLPLAAIIFFNYHILASLRGREEVSRTRCGGSKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFLAFTNSSLNPVIYVFAGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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Organism
Macaca fascicularis, Crab-eating macaque, Cynomolgus monkey
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Bradykinin receptor
Function
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
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Uniprot ID
Q3BCU0
Ensembl ID
ENSG00000100739
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0504166
 Compound Info 
1-Benzyl-1H-benzoimidazole-2-carboxylic acid {2-[6-(4,5-dihydro-1H-imidazol-2-yl)-pyridin-3-ylcarbamoyl]-ethyl}-amide
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C26H25N7O2
  1
1
IC50 = 2 nM
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CP0372962
 Compound Info 
1-benzyl-N-[2-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl-methylamino]-2-oxoethyl]benzimidazole-2-carboxamide
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C28H28N6O2
  1
1
IC50 = 5 nM
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CP0401363
 Compound Info 
1-benzyl-N-[2-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl-methylamino]-2-oxoethyl]-N-ethylbenzimidazole-2-carboxamide
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C30H32N6O2
  1
1
IC50 = 6 nM
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CP0401364
 Compound Info 
1-benzyl-N-[2-[methyl-[[4-(1-methyl-4,5-dihydroimidazol-2-yl)phenyl]methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide
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C29H30N6O2
  1
1
IC50 = 14 nM
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CP0541884
 Compound Info 
1-benzyl-N-ethyl-N-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethyl)-1H-benzo[d]imidazole-2-carboxamide
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C29H38N6O2
  1
1
IC50 = 16 nM
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CP0541886
 Compound Info 
1-benzyl-N-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethyl)-N-propyl-1H-benzo[d]imidazole-2-carboxamide
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C30H40N6O2
  1
1
IC50 = 18 nM
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CP0529150
 Compound Info 
1-benzyl-N-[3-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl-methylamino]-3-oxopropyl]benzimidazole-2-carboxamide
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C29H30N6O2
  1
1
IC50 = 54 nM
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CP0387951
 Compound Info 
1-(1-Benzyl-1H-benzoimidazole-2-carbonyl)-piperidine-4-carboxylic acid [4-(4,5-dihydro-1H-imidazol-2-yl)-benzyl]-methyl-amide
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C32H34N6O2
  1
1
IC50 = 188 nM
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CP0529151
 Compound Info 
1-benzyl-N-[2-[methyl-[[4-(piperidin-1-ylmethyl)phenyl]methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide
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C31H35N5O2
  1
1
IC50 = 196 nM
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CP0502187
 Compound Info 
1-benzyl-N-methyl-N-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethyl)-1H-benzo[d]imidazole-2-carboxamide
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C28H36N6O2
  1
1
IC50 = 268 nM
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CP0541883
 Compound Info 
1-benzyl-N-ethyl-N-(2-oxo-2-(4-(pyridin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole-2-carboxamide
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C28H30N6O2
  1
1
IC50 = 278 nM
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CP0469741
 Compound Info 
1-benzyl-N-(2-oxo-2-(4-(pyridin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole-2-carboxamide
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C26H26N6O2
  1
1
IC50 = 310 nM
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CP0441236
 Compound Info 
1-benzyl-N-[2-[methyl-[(4-pyrimidin-2-ylphenyl)methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide
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C29H26N6O2
  1
1
IC50 = 330 nM
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CP0541885
 Compound Info 
1-benzyl-N-(2-oxo-2-(4-(pyridin-4-yl)piperazin-1-yl)ethyl)-N-propyl-1H-benzo[d]imidazole-2-carboxamide
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C29H32N6O2
  1
1
IC50 = 355 nM
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CP0532843
 Compound Info 
1-benzyl-N-[2-[methyl-[(4-pyridin-2-ylphenyl)methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide
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C30H27N5O2
  1
1
IC50 = 407 nM
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CP0532841
 Compound Info 
1-benzyl-N-isopropyl-N-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethyl)-1H-benzo[d]imidazole-2-carboxamide
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C30H40N6O2
  1
1
IC50 = 465 nM
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CP0529152
 Compound Info 
1-Benzyl-1H-benzoimidazole-2-carboxylic acid [2-(1H-indazol-6-ylcarbamoyl)-ethyl]-amide
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C25H22N6O2
  1
1
IC50 = 524 nM
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CP0476377
 Compound Info 
1-benzyl-N-(3-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-3-oxopropyl)-1H-benzo[d]imidazole-2-carboxamide
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C28H36N6O2
  1
1
IC50 = 601 nM
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CP0387953
 Compound Info 
1-benzyl-N-[2-[(4-imidazol-1-ylphenyl)methyl-methylamino]-2-oxoethyl]benzimidazole-2-carboxamide
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C28H26N6O2
  1
1
IC50 = 626 nM
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CP0541881
 Compound Info 
1-benzyl-N-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethyl)-1H-benzo[d]imidazole-2-carboxamide
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C27H34N6O2
  1
1
IC50 = 686 nM
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CP0387952
 Compound Info 
1-benzyl-N-[2-[methyl-[[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide
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C28H26N6O3
  1
1
IC50 = 718 nM
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CP0515334
 Compound Info 
N-[3-(3H-benzimidazol-5-ylamino)-3-oxopropyl]-1-benzylbenzimidazole-2-carboxamide
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C25H22N6O2
  1
1
IC50 = 744 nM
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CP0469743
 Compound Info 
(1-Benzyl-1H-benzoimidazol-2-yl)-{(S)-2-[4-(1-methyl-piperidin-4-yl)-piperazine-1-carbonyl]-pyrrolidin-1-yl}-methanone
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C30H38N6O2
  1
1
IC50 = 884 nM
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CP0372963
 Compound Info 
1-benzyl-N-(3-oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)-1H-benzo[d]imidazole-2-carboxamide
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C27H28N6O2
  1
1
IC50 = 962 nM
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CP0529147
 Compound Info 
1-benzyl-N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-N-methylbenzimidazole-2-carboxamide
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C26H25N5O
  1
1
IC50 = 1016 nM
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CP0504165
 Compound Info 
1-benzyl-N-[2-[methyl-[[4-(1,3-thiazol-2-yl)phenyl]methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide
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C28H25N5O2S
  1
1
IC50 = 1167 nM
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CP0529149
 Compound Info 
1-benzyl-N-methyl-N-(2-oxo-2-(4-(pyridin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole-2-carboxamide
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C27H28N6O2
  1
1
IC50 = 1176 nM
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CP0529148
 Compound Info 
1-benzyl-N-(1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxobutan-2-yl)-1H-benzo[d]imidazole-2-carboxamide
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C29H38N6O2
  1
1
IC50 = 1303 nM
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CP0441237
 Compound Info 
1-Benzyl-1H-benzoimidazole-2-carboxylic acid [3-(3-oxa-9-aza-spiro[5.5]undec-9-yl)-3-oxo-propyl]-amide
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C27H32N4O3
  1
1
IC50 = 1990 nM
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CP0541889
 Compound Info 
1-benzyl-N-[2-[methyl-[[4-(1H-pyrazol-5-yl)phenyl]methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide
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C28H26N6O2
  1
1
IC50 = 2130 nM
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CP0532842
 Compound Info 
[1-(1-benzylbenzimidazole-2-carbonyl)piperidin-4-yl]-(4-pyridin-4-ylpiperazin-1-yl)methanone
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C30H32N6O2
  1
1
IC50 = 2311 nM
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CP0372965
 Compound Info 
1-Benzyl-1H-benzoimidazole-2-carboxylic acid [3-(2-methyl-2,8-diaza-spiro[4.5]dec-8-yl)-3-oxo-propyl]-amide
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C27H33N5O2
  1
1
IC50 = 2912 nM
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CP0401349
 Compound Info 
(1-Benzyl-1H-benzoimidazol-2-yl)-{(R)-2-[4-(1-methyl-piperidin-4-yl)-piperazine-1-carbonyl]-pyrrolidin-1-yl}-methanone
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C30H38N6O2
  1
1
IC50 = 3219 nM
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CP0491375
 Compound Info 
[1-(1-benzylbenzimidazole-2-carbonyl)piperidin-4-yl]-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]methanone
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C31H40N6O2
  1
1
IC50 = 4021 nM
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CP0541887
 Compound Info 
(1-Benzyl-1H-benzoimidazol-2-yl)-[(R)-2-(4-pyridin-4-yl-piperazine-1-carbonyl)-pyrrolidin-1-yl]-methanone
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C29H30N6O2
  1
1
IC50 = 4074 nM
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CP0372964
 Compound Info 
1-benzyl-N-[2-[[4-(dimethylcarbamoyl)phenyl]methyl-methylamino]-2-oxoethyl]benzimidazole-2-carboxamide
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C28H29N5O3
  1
1
IC50 > 5000 nM
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CP0401350
 Compound Info 
1-Benzyl-1H-benzoimidazole-2-carboxylic acid [3-(9-methyl-3,9-diaza-spiro[5.5]undec-3-yl)-3-oxo-propyl]-amide
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C28H35N5O2
  1
1
IC50 > 5000 nM
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CP0469742
 Compound Info 
1-benzyl-N-isopropyl-N-(2-oxo-2-(4-(pyridin-4-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole-2-carboxamide
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C29H32N6O2
  1
1
IC50 > 5000 nM
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CP0476392
 Compound Info 
2-[(1-Benzyl-1H-benzoimidazol-2-ylmethyl)-ethyl-amino]-1-(4-pyridin-4-yl-piperazin-1-yl)-ethanone
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C28H32N6O
  1
1
IC50 > 5000 nM
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CP0476393
 Compound Info 
2-[(1-Benzyl-1H-benzoimidazol-2-ylmethyl)-ethyl-amino]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone
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C29H40N6O
  1
1
IC50 > 5000 nM
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CP0504188
 Compound Info 
1-Benzyl-1H-benzoimidazole-2-carboxylic acid [3-oxo-3-(2-oxo-1-oxa-3,8-diaza-spiro[4.5]dec-8-yl)-propyl]-amide
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C25H27N5O4
  1
1
IC50 > 5000 nM
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CP0504191
 Compound Info 
(1-Benzyl-1H-benzoimidazol-2-yl)-[(S)-2-(4-pyridin-4-yl-piperazine-1-carbonyl)-pyrrolidin-1-yl]-methanone
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C29H30N6O2
  1
1
IC50 > 5000 nM
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CP0504192
 Compound Info 
1-benzyl-N-[2-[(4-carbamoylphenyl)methyl-methylamino]-2-oxoethyl]benzimidazole-2-carboxamide
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C26H25N5O3
  1
1
IC50 > 5000 nM
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CP0512086
 Compound Info 
(1-benzyl-1H-benzo[d]imidazol-2-yl)(4-(pyridin-4-yl)piperazin-1-yl)methanone
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C24H23N5O
  1
1
IC50 > 5000 nM
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CP0515333
 Compound Info 
1-benzyl-N-[2-[methyl-[[4-(2H-tetrazol-5-yl)phenyl]methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide
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C26H24N8O2
  1
1
IC50 > 5000 nM
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CP0541880
 Compound Info 
(1-benzyl-1H-benzo[d]imidazol-2-yl)(4-(1-methylpiperidin-4-yl)piperazin-1-yl)methanone
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C25H31N5O
  1
1
IC50 > 5000 nM
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CP0541882
 Compound Info 
1-benzyl-N-(1-oxo-1-(4-(pyridin-4-yl)piperazin-1-yl)butan-2-yl)-1H-benzo[d]imidazole-2-carboxamide
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C28H30N6O2
  1
1
IC50 > 5000 nM
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CP0541888
 Compound Info 
1-benzyl-N-[2-[(4-cyanophenyl)methyl-methylamino]-2-oxoethyl]benzimidazole-2-carboxamide
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C26H23N5O2
  1
1
IC50 > 5000 nM
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Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01032 B1 bradykinin receptor Homo sapiens, Human
 Protein Info