General Information of the Protein
Protein ID
PT05966
Protein Name
Potassium voltage-gated channel subfamily A member 3
Secondarily
Protein Name
MK3
Voltage-gated potassium channel subunit Kv1.3
Gene Name
KCNA3
Sequence
MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
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Organism
Mus musculus, Mouse
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Voltage-gated potassium channel
Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
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Uniprot ID
Primary ID:
P16390

Secondarily ID:
A3KMM2
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Ensembl ID
ENSG00000177272
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000309 , NCTC clone 929
Compound ID Compound Name Compound Formula
CP0497496
5-acetyl-7-(4'-bromo)benzyloxy-6-hydroxy-4-methoxybenzofuran
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C18H15BrO5
 1
1
EC50 = 400 nM
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CP0441600
1-(7-(4-chlorobenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C18H15ClO5
 1
1
EC50 = 420 nM
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CP0453160
1-(7-(4-(trifluoromethyl)benzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C19H15F3O5
 1
1
EC50 = 420 nM
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   LI
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CP0562115
1-(7-(3-(trifluoromethoxy)benzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C19H15F3O6
 1
1
EC50 = 450 nM
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   LI
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CP0514182
5-acetyl-4-(4'-chloro)benzyloxy-6-hydroxy-7-methoxybenzofuran
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C18H15ClO5
 1
1
EC50 = 480 nM
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CP0439378
1-(7-(4-benzoylbenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C25H20O6
 1
1
EC50 = 500 nM
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CP0449798
1-(4-(4-bromobenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
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C18H15BrO5
 1
1
EC50 = 500 nM
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CP0475966
1-(4-(4-benzoylbenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
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C25H20O6
 1
1
EC50 = 500 nM
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CP0483371
1-(4-(4-(trifluoromethyl)benzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
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C19H15F3O5
 1
1
EC50 = 510 nM
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CP0483573
1-(4-(3-(trifluoromethoxy)benzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
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C19H15F3O6
 1
1
EC50 = 550 nM
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CP0441598
1-(7-(4-(trifluoromethoxy)benzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C19H15F3O6
 1
1
EC50 = 600 nM
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CP0494688
1-(7-(3-nitrobenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C18H15NO7
 1
1
EC50 = 600 nM
   TI
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CP0552281
1-(7-(3-chlorobenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C18H15ClO5
 1
1
EC50 = 600 nM
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CP0453256
1-(4-(3-methoxybenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
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C19H18O6
 1
1
EC50 = 680 nM
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CP0475965
1-(7-(2-chlorobenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C18H15ClO5
 1
1
EC50 = 700 nM
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CP0483370
1-(4-(4-isopropylbenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
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C21H22O5
 1
1
EC50 = 700 nM
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CP0552280
1-(7-(4-fluorobenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C18H15FO5
 1
1
EC50 = 700 nM
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CP0441601
1-(7-(3-fluorobenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C18H15FO5
 1
1
EC50 = 750 nM
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CP0436602
1,6-bis(5-acetyl-4-ethoxy-7-methoxybenzofuran-6-yloxy)hexane
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C32H38O10
 1
1
EC50 = 800 nM
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CP0442568
1-[4-(1,1'-biphenyl-4-ylmethoxy)-6-hydroxy-7-methoxy-1-benzofuran-5-yl]ethanone
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C24H20O5
 1
1
EC50 = 900 nM
   TI
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CP0441599
1-(7-(4-isopropylbenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C21H22O5
 1
1
EC50 = 1000 nM
   TI
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CP0442250
1-{6-hydroxy-7-methoxy-4-[(3-methylbenzyl)oxy]-1-benzofuran-5-yl}ethanone
   Show/Hide
C19H18O5
 1
1
EC50 = 1000 nM
   TI
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CP0514183
1-(4-(4-fluorobenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C18H15FO5
 1
1
EC50 = 1000 nM
   TI
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CP0441602
1-[7-(Biphenyl-2-ylmethoxy)-6-hydroxy-4-methoxy-benzofuran-5-yl]-ethanone
   Show/Hide
C24H20O5
 1
1
EC50 = 1100 nM
   TI
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CP0371779
1-(4-(3-fluorobenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C18H15FO5
 1
1
EC50 = 1200 nM
   TI
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CP0436844
1-[7-(Biphenyl-4-ylmethoxy)-6-hydroxy-4-methoxy-benzofuran-5-yl]-ethanone
   Show/Hide
C24H20O5
 1
1
EC50 = 1200 nM
   TI
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CP0442281
5-acetyl-4,7-benzyloxy-6-hydroxybenzofuran
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C24H20O5
 1
1
EC50 = 1200 nM
   TI
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CP0442282
1-[6-Hydroxy-4-methoxy-7-(3-methyl-benzyloxy)-benzofuran-5-yl]-ethanone
   Show/Hide
C19H18O5
 1
1
EC50 = 1200 nM
   TI
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CP0460145
5-acetyl-7-benzyloxy-6-hydroxy-4-methoxybenzofuran
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C18H16O5
 1
1
EC50 = 1200 nM
   TI
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CP0475967
1-(4-(2-chlorobenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C18H15ClO5
 1
1
EC50 = 1200 nM
   TI
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CP0442249
1-(4-(3-nitrobenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C18H15NO7
 1
1
EC50 = 1400 nM
   TI
   LI
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CP0523109
1-(4-(3-chlorobenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C18H15ClO5
 1
1
EC50 = 1400 nM
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CP0442248
1-(4-(4-methoxybenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C19H18O6
 1
1
EC50 = 1500 nM
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CP0460143
1-(4-(4-tert-butylbenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C22H24O5
 1
1
EC50 = 1500 nM
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CP0523110
1-(4-(2-fluorobenzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C18H15FO5
 1
1
EC50 = 1700 nM
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CP0442567
1-(4-(4-(trifluoromethoxy)benzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C19H15F3O6
 1
1
EC50 = 1800 nM
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CP0441603
1-[6-Hydroxy-4-methoxy-7-(2-methyl-benzyloxy)-benzofuran-5-yl]-ethanone
   Show/Hide
C19H18O5
 1
1
EC50 = 1900 nM
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CP0460144
1-{6-hydroxy-7-methoxy-4-[(2-methylbenzyl)oxy]-1-benzofuran-5-yl}ethanone
   Show/Hide
C19H18O5
 1
1
EC50 = 2000 nM
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CP0496877
1-[4-(1,1'-biphenyl-2-ylmethoxy)-6-hydroxy-7-methoxy-1-benzofuran-5-yl]ethanone
   Show/Hide
C24H20O5
 1
1
EC50 = 2000 nM
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CP0442566
1-(7-(2-fluorobenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C18H15FO5
 1
1
EC50 = 2500 nM
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CP0490060
1-(4-(benzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
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C18H16O5
 1
1
EC50 = 2500 nM
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CP0523112
3-(4-ethoxy-6-hydroxy-7-methoxybenzofuran-5-yl)-1-(3-hydroxyphenyl)-3-oxopropene
   Show/Hide
C20H18O6
 1
1
EC50 = 2500 nM
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CP0496848
1-(6-hydroxy-4-methoxy-7-phenoxybenzofuran-5-yl)ethanone
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C17H14O5
 1
1
EC50 = 3000 nM
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CP0449799
1-(6-hydroxy-7-methoxy-4-phenoxybenzofuran-5-yl)ethanone
   Show/Hide
C17H14O5
 1
1
EC50 = 4000 nM
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CP0449721
1-(6-hydroxy-4-methoxy-7-(naphthalen-2-ylmethoxy)benzofuran-5-yl)ethanone
   Show/Hide
C22H18O5
 1
1
EC50 = 5000 nM
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CP0453257
1-(6-hydroxy-7-methoxy-4-(naphthalen-2-ylmethoxy)benzofuran-5-yl)ethanone
   Show/Hide
C22H18O5
 1
1
EC50 = 5000 nM
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CP0496878
1-(6-hydroxy-7-methoxy-4-propoxybenzofuran-5-yl)ethanone
   Show/Hide
C14H16O5
 1
1
EC50 = 5000 nM
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CP0441763
1-(7-(4-tert-butylbenzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C22H24O5
 1
1
EC50 = 5800 nM
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CP0453159
5-acetyl-4,7-diethoxy-6-hydroxybenzofuran
   Show/Hide
C14H16O5
 1
1
EC50 = 6000 nM
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CP0486955
1-(7-(4-(benzyloxy)benzyloxy)-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C25H22O6
 1
1
EC50 = 6300 nM
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CP0453258
5-acetyl-4-ethoxy-6-hydroxy-7-methoxybenzofuran
   Show/Hide
C13H14O5
 1
1
EC50 = 7000 nM
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CP0475968
1-(6-hydroxy-7-methoxy-4-(naphthalen-1-ylmethoxy)benzofuran-5-yl)ethanone
   Show/Hide
C22H18O5
 1
1
EC50 = 8000 nM
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CP0496880
1-(6-hydroxy-4-methoxy-7-propoxybenzofuran-5-yl)ethanone
   Show/Hide
C14H16O5
 1
1
EC50 = 8000 nM
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CP0523373
1-(4-(4-(benzyloxy)benzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone
   Show/Hide
C25H22O6
 1
1
EC50 = 8800 nM
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CP0496876
3-((5-acetyl-6-hydroxy-7-methoxybenzofuran-4-yloxy)methyl)benzoic acid
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C19H16O7
 1
1
EC50 > 10000 nM
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CP0523111
1-(7-ethoxy-6-hydroxy-4-methoxybenzofuran-5-yl)ethanone
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C13H14O5
 1
1
EC50 = 10000 nM
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CP0431164
1-(6-Hydroxy-4,7-dimethoxy-benzofuran-5-yl)-ethanone
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C12H12O5
 1
1
EC50 = 45000 nM
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