General Information of the Protein
Protein ID
PT05866
Protein Name
Metabotropic glutamate receptor 1
Gene Name
GRM1
Secondarily
Gene Name
Gprc1a
Mglur1
Sequence
MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGYVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPITIRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSTHFSPPSSPSMVVHRRGPPVATTPPLPPHLSAEETPLFLADSVIPKGLPPPLPQQQQQPPPQPPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNGLRSLYPPPPPPQHLQMLPLQLSTFREEPISPPGEDDDDDSSERFKLLQEFVYEREGNTEEDDLEEEEDLPAASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina (PubMed:26427409).
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Uniprot ID
Primary ID:
P97772

Secondarily ID:
Q6AXG4
Q9EPV6
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Ensembl ID
ENSG00000152822
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0424385
 Compound Info 
tert-butyl 4-[1-(3-fluoropyridin-2-yl)-5-methyltriazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C18H22FN5O2
  1
1
IC50 = 1.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0344016
 Compound Info 
4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl)-N-isopropyl-N-methyl-5,6-dihydropyridine-1(2H)-carboxamide
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C18H23FN6O
  1
1
IC50 = 3.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496067
 Compound Info 
propan-2-yl 4-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C17H20FN5O2
  1
1
IC50 = 3.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0461399
 Compound Info 
tert-butyl 4-[1-(3-fluoropyridin-2-yl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C17H20FN5O2
  1
1
IC50 = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0485591
 Compound Info 
tert-butyl 4-[1-(2-fluorophenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C18H21FN4O2
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432397
 Compound Info 
tert-butyl 4-(1-phenyltriazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
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C18H22N4O2
  1
1
IC50 = 24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0375349
 Compound Info 
tert-butyl 4-[1-(4-fluorophenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C18H21FN4O2
  1
1
IC50 = 31 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480578
 Compound Info 
tert-butyl 4-[1-(3-fluorophenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C18H21FN4O2
  1
1
IC50 = 39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0375350
 Compound Info 
tert-butyl 4-[1-(2-methylphenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C19H24N4O2
  1
1
IC50 = 58 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0375353
 Compound Info 
tert-butyl 4-(1-pyridin-2-yltriazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
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C17H21N5O2
  1
1
IC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0424383
 Compound Info 
1-(3,3-Dimethylbutanolyl)-4-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]-1,2,3,6-tetrahydorohydropyridine
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C19H23FN4O
  1
1
IC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0375446
 Compound Info 
tert-butyl 4-(1-pyridin-3-yltriazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
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C17H21N5O2
  1
1
IC50 = 180 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0494547
 Compound Info 
propan-2-yl 4-[1-(2-fluoropyridin-3-yl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C16H18FN5O2
  1
1
IC50 = 180 nM
 Bioactivity Info 
   TI
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CP0375445
 Compound Info 
N-tert-butyl-4-[1-(2-fluorophenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxamide
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C18H22FN5O
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0424384
 Compound Info 
tert-butyl 4-(1-pyridin-4-yltriazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
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C17H21N5O2
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0461398
 Compound Info 
tert-butyl 4-[1-(2-methoxyphenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
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C19H24N4O3
  1
1
IC50 = 1600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02444 Metabotropic glutamate receptor 1 Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT01994 Metabotropic glutamate receptor 1 Homo sapiens, Human
 Protein Info