General Information of the Protein
Protein ID
PT05750
Protein Name
Protein Wnt-3a
Gene Name
WNT3A
Secondarily
Gene Name
Wnt-3a
Sequence
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
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Organism
Mus musculus, Mouse
Protein Classification
Secreted protein
Function
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites (PubMed:8299937). Required for normal morphogenesis of the developing neural tube (PubMed:8299937). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).
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Uniprot ID
P27467
Subcellular Location
Secreted
Extracellular space
Extracellular matrix
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0666603
 Compound Info 
4-((1R,2R,6S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-quinolin-8-yl-benzamide
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C25H19N3O3
  1
1
IC50 = 77 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0053018
 Compound Info 
2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano-[4,3-d]pyrimidin-4-ol
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C14H11F3N2OS
  1
1
IC50 = 78 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0056588
 Compound Info 
3-(3,4-dimethoxyphenyl)-5-[[4-(4-methoxyphenyl)-5-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,2,4-oxadiazole
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C21H21N5O4S
  1
1
IC50 = 126 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0070829
 Compound Info 
3-(4-methoxyphenyl)-5-[[4-(4-methoxyphenyl)-5-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,2,4-oxadiazole
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C20H19N5O3S
  1
1
IC50 = 215 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0056599
 Compound Info 
3-(4-methoxyphenyl)-5-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,2,4-oxadiazole
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C24H20N6O3S
  1
1
IC50 = 341 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0064177
 Compound Info 
5-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazole
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C24H20N6O2S
  1
1
IC50 = 548 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0056596
 Compound Info 
5-[[4-(4-ethoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methoxyphenyl)-1,2,4-oxadiazole
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C25H22N6O3S
  1
1
IC50 = 919 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0550531
 Compound Info 
5-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-1,2,4-oxadiazole
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C23H18N6O2S
  1
1
IC50 = 1060 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380973
 Compound Info 
CHEMBL1459534
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C21H18N2O6
  1
1
IC50 = 1170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT05054 Protein Wnt-3a Homo sapiens, Human
 Protein Info