General Information of the Protein
Protein ID
PT05054
Protein Name
Protein Wnt-3a
Gene Name
WNT3A
Sequence
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
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Organism
Homo sapiens, Human
Protein Classification
Secreted protein
Function
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).
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Uniprot ID
Primary ID:
P56704

Secondarily ID:
Q3SY79
Q3SY80
Q969P2
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HGNC ID
HGNC:15983
Subcellular Location
Secreted
Extracellular space
Extracellular matrix
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0568633
 Compound Info 
1-(2-ethylphenyl)-3,5-dimethyl-N-quinolin-2-ylpyrazole-4-carboxamide
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C23H22N4O
  1
1
IC50 = 1.3 nM
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CP0546522
 Compound Info 
3,5-dimethyl-1-(2-methylphenyl)-N-quinolin-2-ylpyrazole-4-carboxamide
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C22H20N4O
  1
1
IC50 = 1.5 nM
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CP0168607
 Compound Info 
1-(2-bromophenyl)-5-methyl-N-quinolin-2-ylpyrazole-4-carboxamide
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C20H15BrN4O
  1
1
IC50 = 2.3 nM
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CP0105068
 Compound Info 
N-(cyclopropylmethyl)-2-[4-(4-methoxybenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
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C27H34N4O5
  1
1
IC50 = 3.5 nM
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CP0222485
 Compound Info 
2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)acetamide
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C27H29FN4O4S
  1
1
IC50 = 3.6 nM
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CP0153717
 Compound Info 
5-methyl-1-(2-methylphenyl)-N-quinolin-2-yltriazole-4-carboxamide
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C20H17N5O
  1
1
IC50 = 4.1 nM
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CP0133135
 Compound Info 
2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-(2-methylpropyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
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C26H33FN4O4
  1
1
IC50 = 17 nM
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CP0143651
 Compound Info 
N-(cyclopropylmethyl)-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
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C26H31FN4O4
  1
1
IC50 = 17 nM
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CP0551701
 Compound Info 
1-(2-bromophenyl)-3,5-dimethyl-N-quinolin-2-ylpyrazole-4-carboxamide
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C21H17BrN4O
  1
1
IC50 = 21 nM
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CP0069451
 Compound Info 
2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-propylacetamide
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C25H31FN4O4
  1
1
IC50 = 34 nM
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CP0119796
 Compound Info 
2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
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C22H25FN4O4
  1
1
IC50 = 40 nM
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CP0574983
 Compound Info 
3,5-dimethyl-1-(2-propan-2-ylphenyl)-N-quinolin-2-ylpyrazole-4-carboxamide
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C24H24N4O
  1
1
IC50 = 48 nM
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CP0568634
 Compound Info 
1-(2-bromo-6-fluorophenyl)-3,5-dimethyl-N-quinolin-2-ylpyrazole-4-carboxamide
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C21H16BrFN4O
  1
1
IC50 = 50 nM
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CP0105072
 Compound Info 
2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(pyridin-2-ylmethyl)acetamide
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C28H30FN5O4
  1
1
IC50 = 52 nM
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CP0138202
 Compound Info 
N-benzyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
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C29H31FN4O4
  1
1
IC50 = 65 nM
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CP0351359
 Compound Info 
N-ethyl-2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
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C24H29FN4O4
  1
1
IC50 = 70 nM
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CP0053018
 Compound Info 
2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano-[4,3-d]pyrimidin-4-ol
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C14H11F3N2OS
  1
1
IC50 = 78 nM
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CP0574984
 Compound Info 
1-(2-fluorophenyl)-3,5-dimethyl-N-quinolin-2-ylpyrazole-4-carboxamide
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C21H17FN4O
  1
1
IC50 = 87 nM
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CP0567954
 Compound Info 
1-(2,5-dimethylphenyl)-3,5-dimethyl-N-quinolin-2-ylpyrazole-4-carboxamide
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C23H22N4O
  1
1
IC50 = 96 nM
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CP0574982
 Compound Info 
3,5-dimethyl-1-phenyl-N-quinolin-2-ylpyrazole-4-carboxamide
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C21H18N4O
  1
1
IC50 = 135 nM
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CP0133107
 Compound Info 
2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-methyl-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
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C23H27FN4O4
  1
1
IC50 = 193 nM
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CP0222487
 Compound Info 
3-(2-fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamide
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C22H22FN3O3S
  1
1
IC50 = 304 nM
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CP0543093
 Compound Info 
1-(2-chlorophenyl)-3,5-dimethyl-N-quinolin-2-ylpyrazole-4-carboxamide
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C21H17ClN4O
  1
1
IC50 = 305 nM
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CP0319083
 Compound Info 
3-(4-fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamide
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C22H22FN3O3S
  1
1
IC50 = 483 nM
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CP0118355
 Compound Info 
3-(3-hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamide
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C22H23N3O4S
  1
1
IC50 = 812 nM
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CP0222483
 Compound Info 
N-[(4-oxo-3H-quinazolin-2-yl)methyl]-3-phenyl-N-(thiophen-2-ylmethyl)propanamide
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C23H21N3O2S
  1
1
IC50 = 937 nM
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CP0531564
 Compound Info 
2-[4-(2-hydroxypropan-2-yl)phenyl]-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C16H18N2O3
  1
1
IC50 = 1030 nM
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CP0105073
 Compound Info 
4-chloro-5-cyano-N-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2-methoxybenzamide
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C23H23ClFN3O3
  1
1
IC50 = 1100 nM
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CP0467721
 Compound Info 
2-[4-(trifluoromethoxy)phenyl]-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C14H11F3N2O3
  1
1
IC50 = 1220 nM
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CP0121140
 Compound Info 
3-(4-hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamide
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C22H23N3O4S
  1
1
IC50 = 1350 nM
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CP0133133
 Compound Info 
2-[4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro-3H-quinazolin-4-one
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C15H13F3N2O
  1
1
IC50 = 1410 nM
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CP0040805
 Compound Info 
2-[4-(trifluoromethyl)phenyl]-3H-quinazolin-4-one
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C15H9F3N2O
  1
1
IC50 = 1670 nM
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CP0222484
 Compound Info 
2-[4-(trifluoromethyl)phenyl]-3,6,7,8-tetrahydrothiopyrano[3,2-d]pyrimidin-4-one
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C14H11F3N2OS
  1
1
IC50 = 1720 nM
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CP0118348
 Compound Info 
N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-2-ylmethyl)propanamide
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C22H23N3O3S
  1
1
IC50 = 1920 nM
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CP0314006
 Compound Info 
2-[4-(trifluoromethyl)phenyl]-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C14H11F3N2O2
  1
1
IC50 = 2650 nM
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CP0133110
 Compound Info 
methyl 4-(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)benzoate
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C15H14N2O4
  1
1
IC50 = 3000 nM
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CP0222486
 Compound Info 
3-(2-hydroxyphenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamide
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C22H23N3O4S
  1
1
IC50 = 3770 nM
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CP0075195
 Compound Info 
2-(4-bromophenyl)-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C13H11BrN2O2
  1
1
IC50 = 4140 nM
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CP0479862
 Compound Info 
2-[4-(dimethylamino)phenyl]-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C15H17N3O2
  1
1
IC50 = 4210 nM
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CP0314005
 Compound Info 
2-(4-chlorophenyl)-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C13H11ClN2O2
  1
1
IC50 = 4430 nM
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CP0248932
 Compound Info 
2-(4-methylphenyl)-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C14H14N2O2
  1
1
IC50 = 4630 nM
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CP0069449
 Compound Info 
2-[4-(trifluoromethyl)phenyl]-4a,5,7,7a-tetrahydro-3H-thieno[3,4-d]pyrimidin-4-one
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C13H11F3N2OS
  1
1
IC50 = 5040 nM
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CP0281602
 Compound Info 
2-(4-methoxyphenyl)-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C14H14N2O3
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1
IC50 = 5050 nM
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CP0105070
 Compound Info 
2-(4-methylsulfonylphenyl)-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C14H14N2O4S
  1
1
IC50 = 6290 nM
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CP0075194
 Compound Info 
3-(3-fluorophenyl)-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)propanamide
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C22H22FN3O3S
  1
1
IC50 = 6610 nM
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CP0105071
 Compound Info 
2-thiophen-3-yl-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C11H10N2O2S
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1
IC50 = 8090 nM
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CP0118396
 Compound Info 
N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-pyridin-4-yl-N-(thiophen-2-ylmethyl)propanamide
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C21H22N4O3S
  1
1
IC50 = 8250 nM
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CP0069450
 Compound Info 
N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-3-ylmethyl)propanamide
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C22H23N3O3S
  1
1
IC50 = 8540 nM
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CP0100830
 Compound Info 
2-[4-(trifluoromethyl)phenyl]-3,5,6,8-tetrahydropyrano[3,4-d]pyrimidin-4-one
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C14H11F3N2O2
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1
IC50 = 18100 nM
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CP0222488
 Compound Info 
N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-pyridin-3-yl-N-(thiophen-2-ylmethyl)propanamide
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C21H22N4O3S
  1
1
IC50 = 41000 nM
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CP0105069
 Compound Info 
N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenylpropanamide
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C17H19N3O3
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1
IC50 > 50000 nM
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CP0222489
 Compound Info 
N-ethyl-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenylpropanamide
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C19H23N3O3
  1
1
IC50 > 50000 nM
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CP0305336
 Compound Info 
2-[(thiophen-2-ylmethylamino)methyl]-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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C13H15N3O2S
  1
1
IC50 > 50000 nM
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Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT05750 Protein Wnt-3a Mus musculus, Mouse
 Protein Info