General Information of the Protein
Protein ID
PT05721
Protein Name
Substance-P receptor
Secondarily
Protein Name
NK-1 receptor
Tachykinin receptor 1
Gene Name
TACR1
Sequence
MDNVLPGDSDLFPNISTNSSESNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPGRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYVKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEDEAEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
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Organism
Meriones unguiculatus, Mongolian jird, Gerbillus unguiculatus
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neurokinin receptor
Function
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
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Uniprot ID
Q5DUB1
Ensembl ID
ENSG00000115353
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0528880
 Compound Info 
(2S,3S)-3-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methoxy]-2-phenylpiperidine
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C21H22F3N5O2
  1
1
IC50 = 0.03 nM
 Bioactivity Info 
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CP0443583
 Compound Info 
(2S,3S)-3-[[2-methoxy-5-(5-methyltetrazol-1-yl)phenyl]methoxy]-2-phenylpiperidine
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C21H25N5O2
  1
1
IC50 = 0.05 nM
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CP0559365
 Compound Info 
(2S,3S)-3-[[2-methoxy-5-(tetrazol-1-yl)phenyl]methoxy]-2-phenylpiperidine
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C20H23N5O2
  1
1
IC50 = 0.05 nM
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CP0107813
 Compound Info 
3-[2-{1-[3,5-di(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)-1,4-oxazinan-4-ylmethyl]-4,5-dihydro-1H-1,2,4-triazol-5-one
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C23H21F7N4O3
  1
1
IC50 = 0.09 nM
 Bioactivity Info 
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CP0463077
 Compound Info 
4-[3-[(1-ethyl-4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C29H29F3N2O
  1
1
IC50 = 0.25 nM
 Bioactivity Info 
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CP0504467
 Compound Info 
4-[3-[(1-methyl-4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C28H27F3N2O
  1
1
IC50 = 0.29 nM
 Bioactivity Info 
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CP0447811
 Compound Info 
2,6-difluoro-4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C27H23F5N2O
  1
1
IC50 = 0.32 nM
 Bioactivity Info 
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CP0463078
 Compound Info 
4-[3-[(4-phenyl-1-propan-2-ylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C30H31F3N2O
  1
1
IC50 = 0.39 nM
 Bioactivity Info 
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CP0447810
 Compound Info 
4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C27H25F3N2O
  1
1
IC50 = 0.45 nM
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CP0463073
 Compound Info 
2,5-difluoro-4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C27H23F5N2O
  1
1
IC50 = 0.91 nM
 Bioactivity Info 
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CP0407872
 Compound Info 
4-[[3-(4-methoxyphenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C27H28F3NO2
  1
1
IC50 = 0.93 nM
 Bioactivity Info 
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CP0528874
 Compound Info 
2-fluoro-4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C27H24F4N2O
  1
1
IC50 = 1.1 nM
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CP0528875
 Compound Info 
2-chloro-4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C27H24ClF3N2O
  1
1
IC50 = 1.1 nM
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CP0443710
 Compound Info 
2-methyl-4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C28H27F3N2O
  1
1
IC50 = 1.2 nM
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CP0385768
 Compound Info 
4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]pyridine
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C25H25F3N2O
  1
1
IC50 = 1.6 nM
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CP0452645
 Compound Info 
4-[3-[(1-cyclopropyl-4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C30H29F3N2O
  1
1
IC50 = 1.8 nM
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CP0559362
 Compound Info 
5-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]pyridine-2-carbonitrile
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C26H24F3N3O
  1
1
IC50 = 1.9 nM
 Bioactivity Info 
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CP0504468
 Compound Info 
4-[3-[(1-benzyl-4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C34H31F3N2O
  1
1
IC50 = 2 nM
 Bioactivity Info 
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CP0504472
 Compound Info 
4-[[3-(4-fluorophenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C26H25F4NO
  1
1
IC50 = 2.2 nM
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CP0382160
 Compound Info 
4-[[3-(4-chlorophenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C26H25ClF3NO
  1
1
IC50 = 2.8 nM
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CP0463080
 Compound Info 
4-[[3-(4-ethoxyphenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C28H30F3NO2
  1
1
IC50 = 3.4 nM
 Bioactivity Info 
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CP0407870
 Compound Info 
4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]phenol
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C26H26F3NO2
  1
1
IC50 = 3.6 nM
 Bioactivity Info 
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CP0504473
 Compound Info 
4-[[3-(4-nitrophenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C26H25F3N2O3
  1
1
IC50 = 3.8 nM
 Bioactivity Info 
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CP0547787
 Compound Info 
2,3,5,6-tetrafluoro-4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C27H21F7N2O
  1
1
IC50 = 4.8 nM
 Bioactivity Info 
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CP0443714
 Compound Info 
4-[[3-(3-fluorophenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C26H25F4NO
  1
1
IC50 = 5 nM
 Bioactivity Info 
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CP0443716
 Compound Info 
4-[[3-(3-nitrophenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C26H25F3N2O3
  1
1
IC50 = 5.2 nM
 Bioactivity Info 
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CP0550090
 Compound Info 
4-phenyl-4-[[3-phenyl-5-(trifluoromethyl)phenyl]methoxymethyl]piperidine
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C26H26F3NO
  1
1
IC50 = 6.3 nM
 Bioactivity Info 
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CP0385763
 Compound Info 
4-[[3-(2-nitrophenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C26H25F3N2O3
  1
1
IC50 = 6.5 nM
 Bioactivity Info 
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CP0542712
 Compound Info 
4-[[3-(1,3-benzodioxol-5-yl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C27H26F3NO3
  1
1
IC50 = 7.1 nM
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CP0404467
 Compound Info 
6-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]pyridine-3-carbonitrile
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C26H24F3N3O
  1
1
IC50 = 8.1 nM
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CP0443719
 Compound Info 
4-[[3-(4-methylphenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C27H28F3NO
  1
1
IC50 = 8.4 nM
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CP0504471
 Compound Info 
3-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]phenol
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C26H26F3NO2
  1
1
IC50 = 13 nM
 Bioactivity Info 
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CP0463079
 Compound Info 
methyl 4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzoate
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C28H28F3NO3
  1
1
IC50 = 17 nM
 Bioactivity Info 
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CP0452647
 Compound Info 
N,N-dimethyl-4-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]aniline
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C28H31F3N2O
  1
1
IC50 = 18 nM
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CP0404469
 Compound Info 
4-[[3-(2-fluorophenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C26H25F4NO
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0542708
 Compound Info 
4-[[3-(3-methylphenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C27H28F3NO
  1
1
IC50 = 24 nM
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CP0504470
 Compound Info 
3-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]aniline
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C26H27F3N2O
  1
1
IC50 = 25 nM
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CP0443718
 Compound Info 
4-phenyl-4-[[3-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]phenyl]methoxymethyl]piperidine
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C27H25F6NO
  1
1
IC50 = 30 nM
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CP0528878
 Compound Info 
4-[[3-(2-methyltetrazol-5-yl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C22H24F3N5O
  1
1
IC50 = 36 nM
 Bioactivity Info 
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CP0528877
 Compound Info 
2-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]pyridine
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C25H25F3N2O
  1
1
IC50 = 41 nM
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CP0382162
 Compound Info 
4-[[3-(furan-2-yl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C24H24F3NO2
  1
1
IC50 = 47 nM
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CP0559364
 Compound Info 
3-[3-[(4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile
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C27H25F3N2O
  1
1
IC50 = 49 nM
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CP0528876
 Compound Info 
4-[[3-(2-methoxyphenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C27H28F3NO2
  1
1
IC50 = 54 nM
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CP0443581
 Compound Info 
4-[[3-(1-methyltetrazol-5-yl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C22H24F3N5O
  1
1
IC50 = 65 nM
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CP0447812
 Compound Info 
4-[[3-(2-chlorophenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C26H25ClF3NO
  1
1
IC50 = 68 nM
 Bioactivity Info 
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CP0882061
 Compound Info 
2-(3-(((4-phenylpiperidin-4-yl)methoxy)methyl)-5-(trifluoromethyl)phenyl)thiazole
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C23H23F3N2OS
  1
1
IC50 = 70 nM
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CP0443582
 Compound Info 
4-[[2-methoxy-5-(5-methyltetrazol-1-yl)phenyl]methoxymethyl]-4-phenylpiperidine
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C22H27N5O2
  1
1
IC50 = 87 nM
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CP0504469
 Compound Info 
4-[[3-naphthalen-2-yl-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C30H28F3NO
  1
1
IC50 = 120 nM
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CP0404470
 Compound Info 
4-[[3-(2-methylphenyl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C27H28F3NO
  1
1
IC50 = 130 nM
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CP0463082
 Compound Info 
4-[[3-(5-methyltetrazol-1-yl)-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C22H24F3N5O
  1
1
IC50 = 180 nM
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CP0528879
 Compound Info 
4-phenyl-4-[[3-(2H-tetrazol-5-yl)-5-(trifluoromethyl)phenyl]methoxymethyl]piperidine
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C21H22F3N5O
  1
1
IC50 = 200 nM
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CP0404468
 Compound Info 
4-[[3-naphthalen-1-yl-5-(trifluoromethyl)phenyl]methoxymethyl]-4-phenylpiperidine
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C30H28F3NO
  1
1
IC50 = 540 nM
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CP0382163
 Compound Info 
4-phenyl-4-[[3-(trifluoromethyl)-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methoxymethyl]piperidine
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C22H21F6N5O
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1
IC50 = 700 nM
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Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02240 Substance-P receptor Rattus norvegicus, Rat
 Protein Info