General Information of the Protein
Protein ID
PT05607
Protein Name
C-C motif chemokine 2
Secondarily
Protein Name
HC11
Monocyte chemoattractant protein 1
Monocyte chemotactic and activating factor
Monocyte chemotactic protein 1
Monocyte secretory protein JE
Small-inducible cytokine A2
Gene Name
CCL2
Secondarily
Gene Name
MCP1
SCYA2
Sequence
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).
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Uniprot ID
Primary ID:
P13500

Secondarily ID:
B2R4V3
Q9UDF3
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Ensembl ID
ENSG00000108691
HGNC ID
HGNC:10618
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0857655
 Compound Info 
N-(2-((3S,4S)-1-(4-(benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
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C29H34F3N3O6
  4
1
Kd = 0.23 nM
 Bioactivity Info 
   TI
   LI
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2
Kd = 0.72 nM
 Bioactivity Info 
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3
Kd = 0.9 nM
 Bioactivity Info 
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4
Kd = 1.2 nM
 Bioactivity Info 
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CP0544332
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C29H34F6N2O3
  1
1
Ki = 3.9 nM
 Bioactivity Info 
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CP0479757
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(5-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C28H32F6N2O2
  1
1
Ki = 6.1 nM
 Bioactivity Info 
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CP0544333
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-(6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-7-ylamino)-1-propan-2-ylcyclopentane-1-carboxamide
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C28H30F6N2O3
  1
1
Ki = 6.3 nM
 Bioactivity Info 
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CP0165577
 Compound Info 
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide
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C23H30F6N2O2
  1
1
Ki = 6.8 nM
 Bioactivity Info 
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CP0395825
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(5-chloro-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C27H29ClF6N2O
  1
1
Ki = 18 nM
 Bioactivity Info 
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CP0449657
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C29H34F6N2O2
  1
1
Ki = 27 nM
 Bioactivity Info 
   TI
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CP0395824
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(5-hydroxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C27H30F6N2O2
  1
1
Ki = 29 nM
 Bioactivity Info 
   TI
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CP0238399
 Compound Info 
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-thiopyran-4-ylamino)cyclopentanecarboxamide
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C23H30F6N2OS
  1
1
Ki = 31 nM
 Bioactivity Info 
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CP0404369
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-propan-2-yl-3-(1,2,3,4-tetrahydronaphthalen-1-ylamino)cyclopentane-1-carboxamide
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C28H32F6N2O
  1
1
Ki = 33 nM
 Bioactivity Info 
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CP0389822
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(5-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C28H32F6N2O2
  1
1
Ki = 35 nM
 Bioactivity Info 
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CP0397124
 Compound Info 
(1S,3R)-3-[(4-amino-2,3-dihydro-1H-inden-1-yl)amino]-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-propan-2-ylcyclopentane-1-carboxamide
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C27H31F6N3O
  1
1
Ki = 43 nM
 Bioactivity Info 
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CP0331716
 Compound Info 
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(2,3-dihydro-1H-inden-1-ylamino)-1-isopropylcyclopentanecarboxamide
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C27H30F6N2O
  1
1
Ki = 50 nM
 Bioactivity Info 
   TI
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CP0524891
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(6-cyano-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C28H29F6N3O
  1
1
Ki = 54 nM
 Bioactivity Info 
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CP0397125
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(6-methyl-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C28H32F6N2O
  1
1
Ki = 55 nM
 Bioactivity Info 
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CP0449762
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(4-cyano-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C28H29F6N3O
  1
1
Ki = 70 nM
 Bioactivity Info 
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CP0404118
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(4-hydroxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C27H30F6N2O2
  1
1
Ki = 86 nM
 Bioactivity Info 
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CP0165578
 Compound Info 
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclohexylamino)-1-isopropylcyclopentanecarboxamide
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C24H32F6N2O
  1
1
Ki = 110 nM
 Bioactivity Info 
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CP0461993
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-[(4,5-dimethoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-propan-2-ylcyclopentane-1-carboxamide
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C29H34F6N2O3
  1
1
Ki = 130 nM
 Bioactivity Info 
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CP0404117
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-(3-phenylpropylamino)-1-propan-2-ylcyclopentane-1-carboxamide
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C27H32F6N2O
  1
1
Ki = 134 nM
 Bioactivity Info 
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CP0521838
 Compound Info 
(1S,3R)-3-(benzylamino)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-propan-2-ylcyclopentane-1-carboxamide
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C25H28F6N2O
  1
1
Ki = 437 nM
 Bioactivity Info 
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CP0444063
 Compound Info 
(1S,3R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-(2-phenylethylamino)-1-propan-2-ylcyclopentane-1-carboxamide
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C26H30F6N2O
  1
1
Ki = 2400 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( Monocyte chemotactic and activating factor (CCL2) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Chronic obstructive pulmonary disease [ICD-11: CA22]
Preclinical Drug(s) 1 Preclinical Drug  1
1 RS-504393
 Drug Info 
Preclinical
Chronic obstructive pulmonary disease