General Information of the Protein
Protein ID
PT05586
Protein Name
Nuclear receptor subfamily 2 group E member 1
Secondarily
Protein Name
Nuclear receptor TLX
Protein tailless homolog
Gene Name
NR2E1
Secondarily
Gene Name
TLX
Sequence
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 2
>
Nuclear hormone receptor subfamily 2 group E
>
Nuclear hormone receptor subfamily 2 group E member 1
Function
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
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Uniprot ID
Primary ID:
Q9Y466

Secondarily ID:
Q6ZMP8
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Ensembl ID
ENSG00000112333
HGNC ID
HGNC:7973
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0261899
 Compound Info 
2-butoxy-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]quinoline-4-carboxamide
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C25H23F3N4O2
  1
1
EC50 = 700 nM
 Bioactivity Info 
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CP0489389
 Compound Info 
(4-benzhydrylpiperazin-1-yl)-(1,5-dimethylpyrazol-3-yl)methanone
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C23H26N4O
  1
1
EC50 = 1000 nM
 Bioactivity Info 
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CP0573764
 Compound Info 
N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-4-(4-phenylphenyl)butanamide
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C27H24F3N3O
  1
1
EC50 = 1200 nM
 Bioactivity Info 
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CP0578023
 Compound Info 
4-amino-5-chloro-2-methoxy-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide
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C19H16ClF3N4O2
  1
1
EC50 = 3000 nM
 Bioactivity Info 
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CP0000847
 Compound Info 
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
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C22H19N3O4
  1
1
EC50 = 5000 nM
 Bioactivity Info 
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CP0576788
 Compound Info 
4-(4-hydroxyphenyl)-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]piperazine-1-carboxamide
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C22H22F3N5O2
  1
1
EC50 = 5000 nM
 Bioactivity Info 
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CP0489388
 Compound Info 
N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]acetamide
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C13H12F3N3O
  1
1
EC50 = 11000 nM
 Bioactivity Info 
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CP0280111
 Compound Info 
1-amino-3-naphthalen-1-yloxypropan-2-ol
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C13H15NO2
  2
1
EC50 = 19400 nM
 Bioactivity Info 
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2
EC50 = 43000 nM
 Bioactivity Info 
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CP0041613
 Compound Info 
Anapriline
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C16H21NO2
  2
1
EC50 = 32000 nM
 Bioactivity Info 
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2
EC50 = 37000 nM
 Bioactivity Info 
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CP0072327
 Compound Info 
(2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-propanol;hydrochloride
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C16H21NO2
  1
1
EC50 = 40000 nM
 Bioactivity Info 
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CP0011846
 Compound Info 
1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one
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C21H27NO3
  1
1
EC50 = 47000 nM
 Bioactivity Info 
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CP0571911
 Compound Info 
3-naphthalen-1-yloxy-N-propan-2-ylpropan-1-amine
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C16H21NO
  1
1
EC50 = 50000 nM
 Bioactivity Info 
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CP0559367
 Compound Info 
2-methoxy-3-naphthalen-1-yloxy-N-propan-2-ylpropan-1-amine
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C17H23NO2
  1
1
EC50 = 52000 nM
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CP0951183
 Compound Info 
2,3,4,9-tetrahydro-1H-carbazol-3-amine
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C12H14N2
  2
1
EC50 = 67000 nM
 Bioactivity Info 
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2
EC50 > 100000 nM
 Bioactivity Info 
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CP0072120
 Compound Info 
(-)-(S)-Propranolol
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C16H21NO2
  1
1
EC50 = 72000 nM
 Bioactivity Info 
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CP0065986
 Compound Info 
2,3,4,9-Tetrahydro-1H-beta-carboline
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C11H12N2
  2
1
EC50 = 74000 nM
 Bioactivity Info 
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2
EC50 > 100000 nM
 Bioactivity Info 
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CP0567410
 Compound Info 
1-naphthalen-1-yloxy-3-propan-2-yloxypropan-2-ol
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C16H20O3
  1
1
EC50 = 83000 nM
 Bioactivity Info 
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CP0577376
 Compound Info 
1-[methyl(propan-2-yl)amino]-3-naphthalen-1-yloxypropan-2-ol
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C17H23NO2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0261899
 Compound Info 
2-butoxy-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]quinoline-4-carboxamide
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C25H23F3N4O2
  2
1 EC50 = 5000 nM
2 Kd = 1600 nM