General Information of the Protein
Protein ID
PT05574
Protein Name
Palmitoleoyl-protein carboxylesterase NOTUM
Secondarily
Protein Name
hNOTUM
Gene Name
NOTUM
Secondarily
Gene Name
OK/SW-CL.30
Sequence
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).
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Uniprot ID
Primary ID:
Q6P988

Secondarily ID:
Q8N410
Q8NI82
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HGNC ID
HGNC:27106
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000131 , HEK293-F
Compound ID Compound Name Compound Formula
CP0414627
6,9-difluoro-8-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
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C14H10F2O2S
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0549216
4,5-dihydrobenzo[g][1]benzothiole-2-carboxamide
   Show/Hide
C13H11NOS
 1
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
CP0512395
2-[7-cyclopropyl-6-(trifluoromethyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
   Show/Hide
C12H9F3N2O2S2
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0406186
6-chloro-8-fluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H8ClFO2S
 2
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
2
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0407494
4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide
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C13H11NO2S
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0534345
5,5-dimethyl-4H-benzo[g][1]benzothiole-2-carboxamide
   Show/Hide
C15H15NOS
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0495741
5-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxamide
   Show/Hide
C14H13NOS
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0406188
3-thiatricyclo[8.4.0.02,6]tetradeca-1(14),2(6),4,10,12-pentaene-4-carboxamide
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C14H13NOS
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0511152
6,8-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
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C12H6F2O2S2
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0511153
6,7,8-trifluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
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C12H5F3O2S2
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0401678
6,7-dichloro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
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C13H8Cl2O2S
 1
1
EC50 = 21 nM
   TI
   LI
   LO
   TS
CP0344327
2-(6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
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C11H9ClN2O2S2
 2
1
EC50 = 21 nM
   TI
   LI
   LO
   TS
2
EC50 = 23 nM
   TI
   LI
   LO
   TS
CP0420081
6-fluoro-8-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
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C14H11FO2S
 1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
CP0511169
6-chloro-7-methoxy-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
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C14H11ClO3S
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0462761
6,8-dichloro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
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C13H8Cl2O2S
 1
1
EC50 = 34 nM
   TI
   LI
   LO
   TS
CP0414628
6-fluoro-8-methyl-4H-thieno[3,2-c]chromene-2-carboxylic acid
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C13H9FO3S
 1
1
EC50 = 35 nM
   TI
   LI
   LO
   TS
CP0511151
6-chloro-8-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
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C12H6ClFO3S
 1
1
EC50 = 35 nM
   TI
   LI
   LO
   TS
CP0534346
6-chloro-8-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
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C14H11ClO2S
 1
1
EC50 = 36 nM
   TI
   LI
   LO
   TS
CP0472651
4-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxamide
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C14H13NOS
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0420082
6,7-dichloro-4H-thieno[3,2-c]chromene-2-carboxylic acid
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C12H6Cl2O3S
 1
1
EC50 = 42 nM
   TI
   LI
   LO
   TS
CP0459964
7-chloro-8-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
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C12H6ClFO3S
 1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
CP0511165
8-chloro-6-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H6ClFO3S
 1
1
EC50 = 59 nM
   TI
   LI
   LO
   TS
CP0462760
6,7-difluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
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C13H8F2O2S
 1
1
EC50 = 61 nM
   TI
   LI
   LO
   TS
CP0406187
6-cyano-7-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C15H11NO2S
 1
1
EC50 = 62 nM
   TI
   LI
   LO
   TS
CP0414629
7,8,9-trifluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
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C12H5F3O3S
 1
1
EC50 = 67 nM
   TI
   LI
   LO
   TS
CP0468104
6-cyano-7-fluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C14H8FNO2S
 1
1
EC50 = 70 nM
   TI
   LI
   LO
   TS
CP0472947
6-chloro-7-fluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H8ClFO2S
 1
1
EC50 = 72 nM
   TI
   LI
   LO
   TS
CP0455455
6-cyano-8-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
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C13H6FNO3S
 1
1
EC50 = 75 nM
   TI
   LI
   LO
   TS
CP0406185
6,9-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
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C12H6F2O2S2
 1
1
EC50 = 80 nM
   TI
   LI
   LO
   TS
CP0420084
6-cyano-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C14H9NO2S
 1
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
CP0414589
6-cyano-7-methoxy-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C15H11NO3S
 1
1
EC50 = 87 nM
   TI
   LI
   LO
   TS
CP0385487
2-(5-chloro-6-propylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H11ClN2O2S2
 1
1
EC50 = 88 nM
   TI
   LI
   LO
   TS
CP0385489
2-(5-chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 2
1
EC50 = 107 nM
   TI
   LI
   LO
   TS
2
EC50 = 157 nM
   TI
   LI
   LO
   TS
CP0512394
2-(7-cyclopropyl-6-methylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
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C12H12N2O2S2
 1
1
EC50 = 115 nM
   TI
   LI
   LO
   TS
CP0420083
6-chloro-7-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H6ClFO3S
 1
1
EC50 = 126 nM
   TI
   LI
   LO
   TS
CP0406184
5,5-dioxo-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
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C12H8O4S2
 1
1
EC50 = 139 nM
   TI
   LI
   LO
   TS
CP0455149
2-(6-bromo-5-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
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C9H7BrN2O2S2
 1
1
EC50 = 144 nM
   TI
   LI
   LO
   TS
CP0447120
6-fluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
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C12H7FO2S2
 1
1
EC50 = 160 nM
   TI
   LI
   LO
   TS
CP0434373
N-[[4-[2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetyl]-1H-pyrrol-2-yl]methyl]cyclopropanesulfonamide
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C18H20N4O3S3
 1
1
EC50 = 168 nM
   TI
   LI
   LO
   TS
CP0511164
6,8-dichloro-4H-thieno[3,2-c]chromene-2-carboxylic acid
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C12H6Cl2O3S
 1
1
EC50 = 173 nM
   TI
   LI
   LO
   TS
CP0549215
6-fluoro-5,5-dioxo-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H7FO4S2
 1
1
EC50 = 183 nM
   TI
   LI
   LO
   TS
CP0553202
8-fluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
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C12H7FO2S2
 1
1
EC50 = 186 nM
   TI
   LI
   LO
   TS
CP0385488
2-(5-bromo-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7BrN2O2S2
 1
1
EC50 = 208 nM
   TI
   LI
   LO
   TS
CP0555688
N-[[5-[2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetyl]furan-2-yl]methyl]-2-methylpropanamide
   Show/Hide
C19H21N3O3S2
 1
1
EC50 = 211 nM
   TI
   LI
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   TS
CP0558261
N-[[5-[2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetyl]furan-2-yl]methyl]cyclopropanecarboxamide
   Show/Hide
C19H19N3O3S2
 1
1
EC50 = 249 nM
   TI
   LI
   LO
   TS
CP0550461
2-(5-chloro-6-cyclopropylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H9ClN2O2S2
 1
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
CP0545030
8-chloro-4H-thieno[3,2-c]chromene-2-carboxylic acid
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C12H7ClO3S
 1
1
EC50 = 253 nM
   TI
   LI
   LO
   TS
CP0385485
2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1-[5-(pyrrolidine-1-carbonyl)-1H-pyrrol-3-yl]ethanone
   Show/Hide
C19H20N4O2S2
 1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0385490
2-(5-chloro-6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C10H9ClN2O2S2
 1
1
EC50 = 393 nM
   TI
   LI
   LO
   TS
CP0459445
N-cyano-2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide
   Show/Hide
C11H10N4OS2
 1
1
EC50 = 400 nM
   TI
   LI
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   TS
CP0561078
2-(6-bromo-7-methylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7BrN2O2S2
 1
1
EC50 = 417 nM
   TI
   LI
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   TS
CP0434382
2-(6-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 1
1
EC50 = 435 nM
   TI
   LI
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CP0385483
methyl 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetate
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C11H12N2O2S2
 1
1
EC50 = 445 nM
   TI
   LI
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   TS
CP0553200
4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H8O2S2
 1
1
EC50 = 461 nM
   TI
   LI
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   TS
CP0516469
2-(5-chloro-6-propan-2-ylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H11ClN2O2S2
 1
1
EC50 = 477 nM
   TI
   LI
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   TS
CP0434371
2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-hydroxyacetamide
   Show/Hide
C10H11N3O2S2
 1
1
EC50 = 556 nM
   TI
   LI
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   TS
CP0421067
2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C10H10N2O2S2
 1
1
EC50 = 570 nM
   TI
   LI
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   TS
CP0447145
8-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H7FO3S
 1
1
EC50 = 662 nM
   TI
   LI
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   TS
CP0390443
2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-methylacetamide
   Show/Hide
C11H13N3OS2
 1
1
EC50 = 789 nM
   TI
   LI
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CP0385486
2-(6-ethyl-5-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H12N2O2S2
 1
1
EC50 = 835 nM
   TI
   LI
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   TS
CP0390445
2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetamide
   Show/Hide
C10H11N3OS2
 1
1
EC50 = 857 nM
   TI
   LI
   LO
   TS
CP0452379
2-(6,7-dimethylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C10H10N2O2S2
 1
1
EC50 = 881 nM
   TI
   LI
   LO
   TS
CP0459446
2-(6-chloro-5-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 1
1
EC50 = 885 nM
   TI
   LI
   LO
   TS
CP0407493
4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H10O2S
 1
1
EC50 = 1060 nM
   TI
   LI
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   TS
CP0385484
2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-methylsulfonylacetamide
   Show/Hide
C11H13N3O3S3
 1
1
EC50 = 1462 nM
   TI
   LI
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   TS
CP0459963
9-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H7FO3S
 1
1
EC50 = 1878 nM
   TI
   LI
   LO
   TS
CP0520427
2-(7-chloro-6-methylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 1
1
EC50 = 1965 nM
   TI
   LI
   LO
   TS
CP0406183
5-oxo-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H8O3S2
 1
1
EC50 = 2309 nM
   TI
   LI
   LO
   TS
CP0167846
4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H8O3S
 1
1
EC50 = 3875 nM
   TI
   LI
   LO
   TS
CP0452378
2-(5-ethyl-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H12N2O2S2
 1
1
EC50 = 21928 nM
   TI
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0344327
2-(6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H9ClN2O2S2
 3
1 EC50 = 23 nM
2 IC50 = 1 nM
3 IC50 = 1.1 nM
CP0406186
6-chloro-8-fluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H8ClFO2S
 1
1 IC50 = 0.4 nM
CP0385489
2-(5-chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 1
1 IC50 = 2 nM
CP0544324
6-[3-(trifluoromethoxy)phenyl]sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
   Show/Hide
C12H7F3N4O2S
 1
1 IC50 = 4 nM
CP0549278
6-(3,4-dichlorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
   Show/Hide
C11H6Cl2N4OS
 1
1 IC50 = 5 nM
CP0260378
6-(3-chlorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
   Show/Hide
C11H7ClN4OS
 1
1 IC50 = 6 nM
CP0030978
1-[2,4-dichloro-3-(trifluoromethyl)phenyl]triazole
   Show/Hide
C9H4Cl2F3N3
 1
1 IC50 = 6.5 nM
CP0546179
6-(3,4-dimethylphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
   Show/Hide
C13H12N4OS
 1
1 IC50 = 7 nM
CP0543016
(4E)-2-(3,4-dimethylphenyl)-4-[(5-methylfuran-2-yl)methylidene]-1,3-oxazol-5-one
   Show/Hide
C17H15NO3
 1
1 IC50 = 8.5 nM
CP0549274
6-(3-methylphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
   Show/Hide
C12H10N4OS
 1
1 IC50 = 9 nM
CP0543830
2,2-difluoroethyl 4-(2,3-dihydroindol-1-yl)-4-oxobutanoate
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C14H15F2NO3
 1
1 IC50 = 12 nM
CP0549276
6-(2,3-dichlorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H6Cl2N4OS
 1
1 IC50 = 13 nM
CP0527952
6-(3-methoxyphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C12H10N4O2S
 1
1 IC50 = 15 nM
CP0343987
(4Z)-2-(3,4-dimethylphenyl)-4-[(5-methylfuran-2-yl)methylidene]-1,3-oxazol-5-one
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C17H15NO3
 1
1 IC50 = 17 nM
CP0552676
6-[3-(trifluoromethyl)phenyl]sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C12H7F3N4OS
 1
1 IC50 = 17 nM
CP0488475
6-(3-ethoxyphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C13H12N4O2S
 1
1 IC50 = 20 nM
CP0549277
6-(2,4-dichlorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H6Cl2N4OS
 1
1 IC50 = 20 nM
CP0527951
6-(4-chlorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H7ClN4OS
 1
1 IC50 = 21 nM
CP0575707
6-(3-methylsulfanylphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C12H10N4OS2
 1
1 IC50 = 24 nM
CP0579670
6-(3-propan-2-yloxyphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C14H14N4O2S
 1
1 IC50 = 25 nM
CP0573570
6-(2,4-dimethylphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C13H12N4OS
 1
1 IC50 = 27 nM
CP0579669
6-(4-methylphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C12H10N4OS
 1
1 IC50 = 27 nM
CP0343988
6-[4-(trifluoromethyl)phenyl]sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C12H7F3N4OS
 1
1 IC50 = 28 nM
CP0546177
6-(2-chlorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H7ClN4OS
 1
1 IC50 = 30 nM
CP0579449
6-(3-fluorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H7FN4OS
 1
1 IC50 = 30 nM
CP0438638
2-(2-methylphenoxy)-N-(2-propan-2-ylindazol-6-yl)acetamide
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C19H21N3O2
 1
1 IC50 = 32 nM
CP0573573
6-(2-methylphenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C12H10N4OS
 1
1 IC50 = 50 nM
CP0532023
N-isoquinolin-6-yl-2-(2-methylphenoxy)acetamide
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C18H16N2O2
 1
1 IC50 = 85 nM
CP0552675
6-(2-fluorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H7FN4OS
 1
1 IC50 = 87 nM
CP0573569
6-[2-(trifluoromethyl)phenyl]sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C12H7F3N4OS
 1
1 IC50 = 89 nM
CP0575157
methyl 4-(2,3-dihydroindol-1-yl)-4-oxobutanoate
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C13H15NO3
 2
1 IC50 = 90 nM
2 IC50 = 93 nM
CP0549275
6-(4-fluorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H7FN4OS
 1
1 IC50 = 94 nM
CP0552678
6-(3,4-difluorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H6F2N4OS
 1
1 IC50 = 120 nM
CP0408413
[7-[(4-chlorophenyl)methyl]-1,3-dioxo-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl] 2,3-dihydro-1,4-benzoxazine-4-carboxylate
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C22H21ClN4O5
 1
1 IC50 = 170 nM
CP0573571
6-[6-(trifluoromethyl)pyridin-2-yl]sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H6F3N5OS
 1
1 IC50 = 410 nM
CP0572046
6-(6-methylpyridin-2-yl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one
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C11H9N5OS
 1
1 IC50 = 650 nM
CP0043620
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
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C8H10N4O2
 1
1 IC50 = 18600 nM
CP0348931
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide
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C12H13FN2O
 1
1 IC50 = 37200 nM