General Information of the Protein
| Protein ID |
PT05440
|
||||
|---|---|---|---|---|---|
| Protein Name |
Potassium channel subfamily K member 9
|
||||
| Secondarily Protein Name |
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Two pore potassium channel KT3.2
|
||||
| Gene Name |
KCNK9
|
||||
| Secondarily Gene Name |
TASK3
|
||||
| Sequence |
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
Show/Hide
|
||||
| Organism |
Homo sapiens, Human
|
||||
| Protein Classification |
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Two-pore domain potassium channel
|
||||
| Function |
pH-dependent, voltage-insensitive, background potassium channel protein.
Show/Hide
|
||||
| Uniprot ID |
Show/Hide
|
||||
| HGNC ID | |||||
| Subcellular Location |
Cell membrane
|
||||
Map of Molecular Bioactivity Related to the Protein
|
Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
|
|---|
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Cell Line ID: CL000006 , HEK293
Biochemical Assays
| Compound ID | Compound Name | Compound Formula | |
| CP0234037 |
1-[1-[6-(4-phenylbenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl]butan-1-one
Show/Hide
|
C29H32N4O2
|
1 |
| 1 | IC50 = 35 nM | ||
|---|---|---|---|
Clinical Information about the Protein
Target 1 ( TWIK-related acid-sensitive potassium channel 3 (TASK3) )
| Target Type | Literature-reported Target | ||||
|---|---|---|---|---|---|