General Information of the Protein
Protein ID
PT05288
Protein Name
Bombesin receptor subtype-3
Gene Name
BRS3
Sequence
MSQRQPQSPNQTLISITNDTETSSSAVSNDTTPKGWTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCAKAGGIWIMAMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLSKTFQKHFKAQLCCFKAEQPEPPLGDTPLNNLTVMGRVPATGSAHVSEISVTLFSGSTAKKGEDKV
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
GRP-related receptor
Function
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
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Uniprot ID
Q8K418
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000943 , CellSensor NFAT-bla CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0225161
 Compound Info 
2-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridine
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C22H27N3
  1
1
IC50 = 2.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000866 , HEK293 AequoScreen
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0210909
 Compound Info 
(2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)propan-2-ol
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C20H18F6N4O
  2
1 IC50 = 1.2 nM
2 Ki = 0.6 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01996 Bombesin receptor subtype-3 Homo sapiens, Human
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT05422 Bombesin receptor subtype-3 Mus musculus, Mouse
 Protein Info