General Information of the Protein
Protein ID
PT05222
Protein Name
NF-kappa-B inhibitor alpha
Secondarily
Protein Name
I-kappa-B-alpha
Major histocompatibility complex enhancer-binding protein MAD3
Gene Name
NFKBIA
Secondarily
Gene Name
IKBA
MAD3
NFKBI
Sequence
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL
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Organism
Homo sapiens, Human
Protein Classification
Other cytosolic protein
Function
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:7479976, PubMed:36651806). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7796813, PubMed:7628694, PubMed:7878466, PubMed:7479976).
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Uniprot ID
Primary ID:
P25963

Secondarily ID:
B2R8L6
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Ensembl ID
ENSG00000100906
HGNC ID
HGNC:7797
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0375997
 Compound Info 
WITHANOLIDE E
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C28H38O7
  1
1
IC50 = 18000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0851896
 Compound Info 
Physalin C
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C28H30O9
  1
1
IC50 = 26200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387778
 Compound Info 
PHYSALIN F
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C28H30O10
  1
1
IC50 = 27100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0921599
 Compound Info 
25-hydroxy physalin F
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C28H30O11
  1
1
IC50 = 30100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0468472
 Compound Info 
(1R,2S,5R,8S,9R,17R,18R,21S,24R,26S,27S)-5-hydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacosa-11,14-diene-4,10,22,29-tetrone
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C28H30O9
  1
1
IC50 = 37500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387777
 Compound Info 
(2R)-2-[(1R)-1-hydroxy-1-[(8R,9S,10R,13R,14R,17S)-14-hydroxy-10,13-dimethyl-1-oxo-7,8,9,11,12,15,16,17-octahydro-4H-cyclopenta[a]phenanthren-17-yl]ethyl]-4,5-dimethyl-2,3-dihydropyran-6-one
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C28H38O5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397277
 Compound Info 
PHYSALIN J
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C28H30O10
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0516562
 Compound Info 
PHYSALIN O
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C28H32O10
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524053
 Compound Info 
WITHANOLIDE F
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C28H38O6
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0525010
 Compound Info 
PHYSALIN A
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C28H30O10
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0525011
 Compound Info 
(3R,4S)-4-[(2R,3S)-3-[(8R,9S,10R,13S,14R,17R)-14,17-dihydroxy-10,13-dimethyl-1-oxo-4,7,8,9,11,12,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2,3-dihydroxybutyl]-3-methyloxolan-2-one
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C28H40O7
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0541223
 Compound Info 
(3R,4S)-4-[(2R,3S)-3-[(8R,9S,10R,13S,14R,17S)-14,17-dihydroxy-10,13-dimethyl-1-oxo-4,7,8,9,11,12,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2,3-dihydroxybutyl]-3-methyloxolan-2-one
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C28H40O7
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0561044
 Compound Info 
(2R)-2-[(1R)-1-hydroxy-1-[(8R,9S,10R,13R,14R)-14-hydroxy-10,13-dimethyl-1-oxo-7,8,9,11,12,15-hexahydro-4H-cyclopenta[a]phenanthren-17-yl]ethyl]-4,5-dimethyl-2,3-dihydropyran-6-one
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C28H36O5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0936768
 Compound Info 
25-hydroxy physalin J
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C28H30O11
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0948147
 Compound Info 
Physalin N
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C28H30O10
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0948741
 Compound Info 
Physalin III
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C28H32O10
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000106 , OCI-Ly3
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( NF-kappa-B inhibitor alpha (NFKBIA) )
Target Type Clinical trial Target
Disease 2 Target-related Diseases  2
1 Breast cancer [ICD-11: 2C60-2C65]
2 Metabolic syndrome x [ICD-11: 5C50-5D2Z]
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 I3C
 Drug Info 
Phase 3
Breast cancer
2 Fucoxanthin
 Drug Info 
Phase 2
Metabolic syndrome x