General Information of the Protein
Protein ID
PT05210
Protein Name
Alkaline phosphatase, placental type
Secondarily
Protein Name
Alkaline phosphatase Regan isozyme
Placental alkaline phosphatase 1
Gene Name
ALPP
Secondarily
Gene Name
PLAP
Sequence
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Phosphatase
Function
Alkaline phosphatase that can hydrolyze various phosphate compounds.
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Uniprot ID
Primary ID:
P05187

Secondarily ID:
P05188
P06861
Q53S78
Q96DB7
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Ensembl ID
ENSG00000163283
HGNC ID
HGNC:439
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000109 , COS-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0221680
 Compound Info 
N-(2,5-dimethylphenyl)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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C17H17N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379748
 Compound Info 
1-[2-(1,3-benzodioxol-5-yl)ethyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C17H15N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379750
 Compound Info 
N-[(2-chlorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H16ClN3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379753
 Compound Info 
3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide
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C18H16F3N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379756
 Compound Info 
N-[2-(1,3-benzodioxol-5-yl)ethyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C19H19N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379757
 Compound Info 
N-(3,4-dimethoxyphenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C18H19N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379758
 Compound Info 
N-[(4-chlorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H16ClN3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379759
 Compound Info 
N-(2,5-dimethylphenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C18H19N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379761
 Compound Info 
1-[(4-methoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C16H15N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379784
 Compound Info 
N-[(3-fluorophenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C18H18FN3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379785
 Compound Info 
N-(3,4-dimethylphenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C18H19N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379919
 Compound Info 
N-benzyl-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H17N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0379922
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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C17H15N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0420780
 Compound Info 
N-[(4-methylphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C18H19N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0420781
 Compound Info 
N-(2,5-dimethylphenyl)-3-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C19H21N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0420782
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C18H17N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0420783
 Compound Info 
N-[(3-methoxyphenyl)methyl]-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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C17H17N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0431421
 Compound Info 
N-[(2-methylphenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C19H21N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0431422
 Compound Info 
3-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-o-anisyl-propionamide
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C18H19N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0431749
 Compound Info 
N-[2-(4-methoxyphenyl)ethyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C20H23N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0431754
 Compound Info 
N-[(3-cyanophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C18H16N4O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0433080
 Compound Info 
N-(2,4-dimethoxyphenyl)-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C19H21N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0433081
 Compound Info 
N-[2-(4-hydroxyphenyl)ethyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C19H21N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0433082
 Compound Info 
N-[(3-chlorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H16ClN3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0433083
 Compound Info 
N-[3-(1,3-benzodioxol-5-yl)propyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C20H21N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0433084
 Compound Info 
N-[(3-fluorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H16FN3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0433085
 Compound Info 
N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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C18H17N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0433086
 Compound Info 
N-[(4-methoxyphenyl)methyl]-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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C17H17N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0433087
 Compound Info 
N-[2-(3,4-dimethoxyphenyl)ethyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C21H25N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0443495
 Compound Info 
N-(2-fluorophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C16H14FN3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0444274
 Compound Info 
N-(3,4-dimethoxyphenyl)-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C19H21N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0444293
 Compound Info 
N-(2-chlorophenyl)-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C17H16ClN3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0444294
 Compound Info 
N-(1,3-benzodioxol-5-yl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H15N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0444295
 Compound Info 
1-(1,3-benzodioxol-5-yl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C15H11N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0446941
 Compound Info 
3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
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C18H16F3N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0447232
 Compound Info 
N-[(4-hydroxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H17N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0456652
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C19H19N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0457355
 Compound Info 
N-[(2,4-dimethoxyphenyl)methyl]-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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C18H19N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0457379
 Compound Info 
N-[(3,4-dihydroxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H17N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0457380
 Compound Info 
1-(3-cyanophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C15H10N4O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0457381
 Compound Info 
N-[(2,4-dimethoxyphenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C20H23N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0457382
 Compound Info 
N-[(4-fluorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H16FN3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0457383
 Compound Info 
N-[(4-methoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C18H19N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0458646
 Compound Info 
1-(4-cyanophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C15H10N4O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0458648
 Compound Info 
N-(4-cyanophenyl)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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C16H12N4O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0458650
 Compound Info 
1-(2,5-dimethylphenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C16H15N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0460353
 Compound Info 
3-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N-m-anisyl-propionamide
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C18H19N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0460354
 Compound Info 
1-(3,4-dimethoxyphenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C16H15N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0460355
 Compound Info 
N-(3-cyanophenyl)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide
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C16H12N4O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0461277
 Compound Info 
1-[(2,4-dimethoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C17H17N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0467288
 Compound Info 
N-(3-cyanophenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide
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C17H14N4O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0481235
 Compound Info 
N-[(3,4-dimethoxyphenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C20H23N3O7S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0481236
 Compound Info 
1-[(3-methoxyphenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]urea
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C16H15N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0493898
 Compound Info 
N-[(2-methoxyphenyl)methyl]-4-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]butanamide
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C19H21N3O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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