General Information of the Protein
Protein ID
PT04984
Protein Name
DNA primase
Gene Name
UL52
Sequence
MGQEDGNRGERRAAGTPVEVTALYATDGCVITSSIALLTNSLLGAEPVYIFSYDAYTHDGRADGPTEQDRFEESRALYQASGGLNGDSFRVTFCLLGTEVGGTHQARGRTRPMFVCRFERADDVAALQDALAHGTPLQPDHIAATLDAEATFALHANMILALTVAINNASPRTGRDAAAAQYDQGASLRSLVGRTSLGQRGLTTLYVHHEVRVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLTTRYYLLQAQRLGGAGATYDLQAIKDICATYAIPHAPRPDTVSAASLTSFAAITRFCCTSQYARGAAAAGFPLYVERRIAADVRETSALEKFITHDRSCLRVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPNPAASTEQPSPLGREAVEQFFCHVRAQLNIGEYVKHNVTPRETVLDGDTAKAYLRARTYAPGALTPAPAYCGAVDSATKMMGRLADAEKLLVPRGWPAFAPASPGEDTAGGTPPPQTCGIVKRLLRLAATEQQGPTPPAIAALIRNAAVQTPLPVYRISMVPTGQAFAALAWDDWARITRDARLAEAVVSAEAAAHPDHGALGRRLTDRIRAQGPVMPPGGLDAGGQMYVNRNEIFNGALAITNIILDLDIALKEPVPFRRLHEALGHFRRGALAAVQLLFPAARVDPDAYPCYFFKSACRPGPASVGSGSGLGNDDDGDWFPCYDDAGDEEWAEDPGAMDTSHDPPDDEVAYFDLCHEVGPTAEPRETDSPVCSCTDKIGLRVCMPVPAPYVVHGSLTMRGVARVIQQAVLLDRDFVEAIGSYVKNFLLIDTGVYAHGHSLRLPYFAKIAPDGPACGRLLPVFVIPPACKDVPAFVAAHADPRRFHFHAPPTYLASPREIRVLHSLGGDYVSFFERKASRNALEHFGRRETLTEVLGRYNVQPDAGGTVEGFASELLGRIVACIETHFPEHAGEYQAVSVRRAVSKDDWVLLQLVPVRGTLQQSLSCLRFKHGRASRATARTFVALSVGANNRLCVSLCQQCFAAKCDSNRLHTLFTIDAGTPCSPSVPCSTSQPSS
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Organism
Human herpesvirus 1 (strain 17), HHV-1, Human herpes simplex virus 1
Protein Classification
Other nuclear protein
Function
Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
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Uniprot ID
Primary ID:
P10236

Secondarily ID:
B9VQI1
Q09I82
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Subcellular Location
Host nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0196754
 Compound Info 
2-Amino-6-(3,5-dichloro-phenylamino)-3H-pyrimidin-4-one
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C10H8Cl2N4O
  1
1
IC50 = 770 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0201074
 Compound Info 
2-N-(3,4-dichlorophenyl)-7H-purine-2,6-diamine
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C11H8Cl2N6
  1
1
IC50 = 850 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0273920
 Compound Info 
2-Amino-6-(3,4-dichloro-phenylamino)-3H-pyrimidin-4-one
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C10H8Cl2N4O
  1
1
IC50 = 850 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0366311
 Compound Info 
2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-one
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C11H7Cl2N5O
  1
1
IC50 = 880 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0469893
 Compound Info 
2-(3,5-Dichloro-phenylamino)-1,9-dihydro-purin-6-one
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C11H7Cl2N5O
  1
1
IC50 = 910 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0196996
 Compound Info 
2-N-(3,5-dichlorophenyl)-7H-purine-2,6-diamine
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C11H8Cl2N6
  1
1
IC50 = 920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0104162
 Compound Info 
6-(3,4-Dichloro-phenylamino)-1H-pyrimidine-2,4-dione
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C10H7Cl2N3O2
  1
1
IC50 > 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0268836
 Compound Info 
6-(3,5-Dichloro-phenylamino)-1H-pyrimidine-2,4-dione
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C10H7Cl2N3O2
  1
1
IC50 > 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0201074
 Compound Info 
2-N-(3,4-dichlorophenyl)-7H-purine-2,6-diamine
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C11H8Cl2N6
  1
1 IC50 = 13000 nM