General Information of the Protein
Protein ID
PT04903
Protein Name
Sigma intracellular receptor 2
Secondarily
Protein Name
Transmembrane protein 97
Gene Name
TMEM97
Secondarily
Gene Name
S2r
Sequence
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
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Organism
Rattus norvegicus, Rat
Protein Classification
Unclassified protein
Function
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
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Uniprot ID
Q5U3Y7
Ensembl ID
ENSG00000109084
Subcellular Location
Nucleus membrane
Rough endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000868 , PC12
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0073146
 Compound Info 
benzyl 7-(4-cyclopentylpiperazin-1-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylate
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C26H33N3O2
  1
1
Ki = 2.7 nM
 Bioactivity Info 
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CP0451667
 Compound Info 
benzyl (1R,8R)-5-(4-cyclopentylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C28H35N3O2
  1
1
Ki = 3.6 nM
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CP0545188
 Compound Info 
benzyl (1S,8R)-5-(4-cyclopentylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C28H35N3O2
  1
1
Ki = 3.6 nM
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CP0454752
 Compound Info 
benzyl (1R,8R)-4-(4-cyclohexylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C29H37N3O2
  1
1
Ki = 4.9 nM
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CP0558657
 Compound Info 
benzyl (1R,8R)-5-(4-cyclobutylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C27H33N3O2
  1
1
Ki = 5 nM
 Bioactivity Info 
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CP0454751
 Compound Info 
benzyl (1R,8R)-5-(4-propylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C26H33N3O2
  1
1
Ki = 5.1 nM
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CP0548988
 Compound Info 
benzyl (1R,8R)-5-[4-(cyclopentylmethyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C29H37N3O2
  1
1
Ki = 6.2 nM
 Bioactivity Info 
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CP0225367
 Compound Info 
benzyl 5-(4-cyclopentylpiperazin-1-yl)-1,3-dihydroisoindole-2-carboxylate
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C25H31N3O2
  1
1
Ki = 8.2 nM
 Bioactivity Info 
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CP0455799
 Compound Info 
benzyl (1R,8R)-4-(4-propan-2-ylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C26H33N3O2
  1
1
Ki = 8.3 nM
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CP0457295
 Compound Info 
benzyl (1R,8R)-5-[4-(3-methoxy-3-oxopropyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C27H33N3O4
  1
1
Ki = 8.8 nM
 Bioactivity Info 
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CP0411208
 Compound Info 
benzyl (1R,8R)-4-(4-cyclopentylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C28H35N3O2
  1
1
Ki = 11.1 nM
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CP0413663
 Compound Info 
benzyl (1R,8R)-5-(4-cyclohexylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C29H37N3O2
  1
1
Ki = 12.5 nM
 Bioactivity Info 
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CP0523445
 Compound Info 
benzyl 8-(4-cyclopentylpiperazin-1-yl)-1,3,4,5-tetrahydro-2-benzazepine-2-carboxylate
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C27H35N3O2
  1
1
Ki = 13 nM
 Bioactivity Info 
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CP0476416
 Compound Info 
1-[3-(4-tert-butylphenyl)propyl]-4-methylpiperidine
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C19H31N
  1
1
Ki = 13.8 nM
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CP0413662
 Compound Info 
benzyl (1R,8R)-5-(4-propan-2-ylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C26H33N3O2
  1
1
Ki = 14.5 nM
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CP0455800
 Compound Info 
benzyl (1R,8R)-5-[4-(2-methylprop-2-enyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C27H33N3O2
  1
1
Ki = 17.5 nM
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CP0523447
 Compound Info 
benzyl (1S,8R)-5-[4-(2-methylprop-2-enyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C27H33N3O2
  1
1
Ki = 17.5 nM
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CP0541575
 Compound Info 
benzyl 8-[4-(2-methylprop-2-enyl)piperazin-1-yl]-1,3,4,5-tetrahydro-2-benzazepine-2-carboxylate
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C26H33N3O2
  1
1
Ki = 19 nM
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CP0411209
 Compound Info 
benzyl (1R,8R)-5-[4-(3-ethoxy-3-oxopropyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C28H35N3O4
  1
1
Ki = 23.8 nM
 Bioactivity Info 
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CP0548826
 Compound Info 
benzyl (1S,8R)-5-[4-(3-ethoxy-3-oxopropyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C28H35N3O4
  1
1
Ki = 23.8 nM
 Bioactivity Info 
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CP0248167
 Compound Info 
benzyl 7-[4-(2-methylprop-2-enyl)piperazin-1-yl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
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C25H31N3O2
  1
1
Ki = 25 nM
 Bioactivity Info 
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CP0451668
 Compound Info 
benzyl (1R,8R)-4-[4-(cyclopentylmethyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C29H37N3O2
  1
1
Ki = 26 nM
 Bioactivity Info 
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CP0402793
 Compound Info 
benzyl (1R,8R)-4-(4-propylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C26H33N3O2
  1
1
Ki = 29.3 nM
 Bioactivity Info 
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CP0566525
 Compound Info 
1-[3-(4-tert-butylphenyl)propyl]piperidine
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C18H29N
  1
1
Ki = 31.5 nM
 Bioactivity Info 
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CP0389575
 Compound Info 
4-(2-benzyl-3,4-dihydro-1H-isoquinolin-6-yl)morpholine
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C20H24N2O
  1
1
Ki = 33 nM
 Bioactivity Info 
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CP0411207
 Compound Info 
benzyl (1R,8R)-4-(4-cyclobutylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C27H33N3O2
  1
1
Ki = 42.3 nM
 Bioactivity Info 
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CP0562929
 Compound Info 
benzyl (1R,8R)-4-[4-(2-methylprop-2-enyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C27H33N3O2
  1
1
Ki = 46.7 nM
 Bioactivity Info 
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CP0558662
 Compound Info 
(1R,8R)-9-(3,5-dichlorophenyl)sulfonyl-4-(4-methylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene
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C22H25Cl2N3O2S
  1
1
Ki = 48 nM
 Bioactivity Info 
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CP0233820
 Compound Info 
2-benzyl-6-(3-methoxyphenyl)-3,4-dihydro-1H-isoquinoline
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C23H23NO
  1
1
Ki = 57 nM
 Bioactivity Info 
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CP0248165
 Compound Info 
2-benzyl-5-(3-methoxyphenyl)-1,3-dihydroisoindole
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C22H21NO
  1
1
Ki = 65 nM
 Bioactivity Info 
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CP0566522
 Compound Info 
(2R,6R)-4-[3-(4-tert-butylphenyl)propyl]-2,6-dimethylmorpholine
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C19H31NO
  1
1
Ki = 66.1 nM
 Bioactivity Info 
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CP0570388
 Compound Info 
(1R,8R)-9-(3,5-dichlorophenyl)sulfonyl-5-(4-methylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene
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C22H25Cl2N3O2S
  1
1
Ki = 67 nM
 Bioactivity Info 
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CP0558659
 Compound Info 
benzyl (1R,8R)-5-(4-prop-2-enylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C26H31N3O2
  1
1
Ki = 76.4 nM
 Bioactivity Info 
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CP0452098
 Compound Info 
4-[3-(4-tert-butylphenyl)propyl]-2,6-dimethylmorpholine
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C19H31NO
  1
1
Ki = 77.9 nM
 Bioactivity Info 
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CP0451628
 Compound Info 
benzyl (1R,8R)-5-(4-benzylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C30H33N3O2
  1
1
Ki = 80.8 nM
 Bioactivity Info 
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CP0446306
 Compound Info 
4-(2-benzyl-1,3,4,5-tetrahydro-2-benzazepin-7-yl)morpholine
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C21H26N2O
  1
1
Ki = 81 nM
 Bioactivity Info 
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CP0459075
 Compound Info 
benzyl 8-[4-(3-ethoxy-3-oxopropyl)piperazin-1-yl]-1,3,4,5-tetrahydro-2-benzazepine-2-carboxylate
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C27H35N3O4
  1
1
Ki = 83 nM
 Bioactivity Info 
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CP0558656
 Compound Info 
benzyl (1R,8R)-5-(4-methylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C24H29N3O2
  1
1
Ki = 89.7 nM
 Bioactivity Info 
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CP0523446
 Compound Info 
benzyl (1S,8R)-5-(4-methylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C24H29N3O2
  1
1
Ki = 89.7 nM
 Bioactivity Info 
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CP0558658
 Compound Info 
benzyl (1R,8R)-4-(4-benzylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C30H33N3O2
  1
1
Ki = 90 nM
 Bioactivity Info 
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CP0558661
 Compound Info 
benzyl (1R,8R)-4-[4-(3-ethoxy-3-oxopropyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C28H35N3O4
  1
1
Ki = 111.3 nM
 Bioactivity Info 
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CP0451629
 Compound Info 
(1R,8R)-9-benzyl-4-(3-methoxyphenyl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene
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C25H25NO
  1
1
Ki = 121 nM
 Bioactivity Info 
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CP0392997
 Compound Info 
(1S,8R)-9-benzyl-4-(3-methoxyphenyl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene
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C25H25NO
  1
1
Ki = 121.1 nM
 Bioactivity Info 
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CP0545186
 Compound Info 
benzyl 7-(4-methylpiperazin-1-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylate
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C22H27N3O2
  1
1
Ki = 129 nM
 Bioactivity Info 
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CP0111182
 Compound Info 
benzyl 5-[4-(3-ethoxy-3-oxopropyl)piperazin-1-yl]-1,3-dihydroisoindole-2-carboxylate
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C25H31N3O4
  1
1
Ki = 134 nM
 Bioactivity Info 
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CP0392996
 Compound Info 
benzyl 8-(4-methylpiperazin-1-yl)-1,3,4,5-tetrahydro-2-benzazepine-2-carboxylate
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C23H29N3O2
  1
1
Ki = 151 nM
 Bioactivity Info 
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CP0248166
 Compound Info 
benzyl 5-[4-(2-methylprop-2-enyl)piperazin-1-yl]-1,3-dihydroisoindole-2-carboxylate
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C24H29N3O2
  1
1
Ki = 153 nM
 Bioactivity Info 
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CP0327799
 Compound Info 
4-(2-benzyl-1,3-dihydroisoindol-5-yl)morpholine
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C19H22N2O
  1
1
Ki = 166 nM
 Bioactivity Info 
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CP0457292
 Compound Info 
benzyl (1R,8R)-4-(4-prop-2-enylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C26H31N3O2
  1
1
Ki = 172 nM
 Bioactivity Info 
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CP0389578
 Compound Info 
benzyl 7-[4-(3-ethoxy-3-oxopropyl)piperazin-1-yl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
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C26H33N3O4
  1
1
Ki = 198 nM
 Bioactivity Info 
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CP0549611
 Compound Info 
benzyl (1R,8R)-4-(4-methylpiperazin-1-yl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C24H29N3O2
  1
1
Ki = 269 nM
 Bioactivity Info 
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CP0558660
 Compound Info 
benzyl (1R,8R)-4-[4-(3-methoxy-3-oxopropyl)piperazin-1-yl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-9-carboxylate
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C27H33N3O4
  1
1
Ki = 297 nM
 Bioactivity Info 
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CP0762474
 Compound Info 
2-((5-Chlorothiophen-2-yl)ethynyl)-N-(4-hydroxy-3-methoxyphenethyl)-9H-purin-6-amine
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C20H16ClN5O2S
  1
1
Ki = 370 nM
 Bioactivity Info 
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CP0523449
 Compound Info 
2-benzyl-7-(3-methoxyphenyl)-1,3,4,5-tetrahydro-2-benzazepine
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C24H25NO
  1
1
Ki = 440 nM
 Bioactivity Info 
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CP0335097
 Compound Info 
benzyl 5-(4-methylpiperazin-1-yl)-1,3-dihydroisoindole-2-carboxylate
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C21H25N3O2
  1
1
Ki = 553 nM
 Bioactivity Info 
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CP0402794
 Compound Info 
4-[(1R,8R)-9-benzyl-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-4-yl]morpholine
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C22H26N2O
  1
1
Ki = 562.3 nM
 Bioactivity Info 
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CP0545187
 Compound Info 
4-[(1S,8R)-9-benzyl-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-4-yl]morpholine
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C22H26N2O
  1
1
Ki = 562.3 nM
 Bioactivity Info 
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CP0212719
 Compound Info 
(+-)-cis-4-(3-(4-tert-butylphenyl)-2-methylpropyl)-2,6-dimethylmorpholine
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C20H33NO
  1
1
Ki = 854 nM
 Bioactivity Info 
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CP0875485
 Compound Info 
N-(3-Chlorobenzyl)-2-((5-chlorothiophen-2-yl)ethynyl)-9H-purin-6-amine
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C18H11Cl2N5S
  1
1
Ki = 900 nM
 Bioactivity Info 
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CP0567091
 Compound Info 
4-[3-(4-tert-butylphenyl)propyl]morpholine
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C17H27NO
  1
1
Ki = 930 nM
 Bioactivity Info 
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CP0417228
 Compound Info 
4-[(1R,8R)-9-benzyl-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-5-yl]morpholine
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C22H26N2O
  1
1
Ki = 1183 nM
 Bioactivity Info 
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CP0547169
 Compound Info 
(1R,8R)-9-benzyl-5-(3-methoxyphenyl)-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene
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C25H25NO
  1
1
Ki = 1548 nM
 Bioactivity Info 
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CP0883984
 Compound Info 
2-((5-Chlorothiophen-2-yl)ethynyl)-N-propyl-9H-purin-6-amine
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C14H12ClN5S
  1
1
Ki = 1910 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0566524
 Compound Info 
4-(3-phenylpropyl)morpholine
   Show/Hide
C13H19NO
  1
1
Ki = 2019 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000992 , rat PC3
 Cell Line Info