General Information of the Protein
Protein ID
PT04865
Protein Name
5-hydroxytryptamine receptor 3A
Secondarily
Protein Name
5-hydroxytryptamine receptor 3
Serotonin receptor 3A
Serotonin-gated ion channel receptor
Gene Name
HTR3A
Secondarily
Gene Name
5ht3
Htr3
Sequence
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
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Organism
Rattus norvegicus, Rat
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
5HT3 receptor
Function
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
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Uniprot ID
P35563
Ensembl ID
ENSG00000166736
Subcellular Location
Postsynaptic cell membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Compound ID Compound Name Compound Formula
CP0078124
5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-pyridin-2-ylpyridazin-3-one
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C23H26N4O2
 1
1
Ki = 3.7 nM
   TI
   LI
   LO
   TS
CP0418405
2-(6-methylpyridin-2-yl)-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
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C24H28N4O2
 1
1
Ki = 4.4 nM
   TI
   LI
   LO
   TS
CP0499752
6-methyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-pyridin-2-ylpyridazin-3-one
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C24H28N4O2
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0510682
3-methyl-4-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
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C19H25N3O2
 1
1
Ki = 5.1 nM
   TI
   LI
   LO
   TS
CP0508912
2-methyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
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C19H25N3O2
 1
1
Ki = 5.5 nM
   TI
   LI
   LO
   TS
CP0431282
2,6-dimethyl-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
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C20H27N3O2
 1
1
Ki = 6.5 nM
   TI
   LI
   LO
   TS
CP0499754
5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-propan-2-ylpyridazin-3-one
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C21H29N3O2
 1
1
Ki = 7 nM
   TI
   LI
   LO
   TS
CP0456828
4-[4-[3-(azepan-1-yl)propoxy]phenyl]-3-methyl-1H-pyridazin-6-one
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C20H27N3O2
 1
1
Ki = 7.5 nM
   TI
   LI
   LO
   TS
CP0046463
3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
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C18H23N3O2
 1
1
Ki = 8.5 nM
   TI
   LI
   LO
   TS
CP0397274
4-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one
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C18H23N3O2
 1
1
Ki = 8.5 nM
   TI
   LI
   LO
   TS
CP0431283
2-(3-methylpyridin-2-yl)-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
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C24H28N4O2
 1
1
Ki = 8.6 nM
   TI
   LI
   LO
   TS
CP0495133
5-[4-[3-(azepan-1-yl)propoxy]phenyl]-2-pyridin-2-ylpyridazin-3-one
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C24H28N4O2
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
CP0517440
5-[4-(3-piperidin-1-ylpropoxy)phenyl]-2-pyridin-2-ylpyridazin-3-one
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C23H26N4O2
 1
1
Ki = 16 nM
   TI
   LI
   LO
   TS
CP0418406
6-methyl-2-(3-methylpyridin-2-yl)-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one
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C25H30N4O2
 1
1
Ki = 17 nM
   TI
   LI
   LO
   TS
CP0416895
2,6-dimethyl-5-[4-(3-piperidin-1-ylpropoxy)phenyl]pyridazin-3-one
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C20H27N3O2
 1
1
Ki = 18 nM
   TI
   LI
   LO
   TS
CP0416894
5-[4-[3-(azepan-1-yl)propoxy]phenyl]-2-methylpyridazin-3-one
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C20H27N3O2
 1
1
Ki = 22 nM
   TI
   LI
   LO
   TS
CP0459851
3-methyl-4-[4-(3-piperidin-1-ylpropoxy)phenyl]-1H-pyridazin-6-one
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C19H25N3O2
 1
1
Ki = 23 nM
   TI
   LI
   LO
   TS
CP0391333
4-[4-(3-piperidin-1-ylpropoxy)phenyl]-1H-pyridazin-6-one
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C18H23N3O2
 1
1
Ki = 28 nM
   TI
   LI
   LO
   TS
CP0418409
5-[4-[3-[(2S)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-pyridin-2-ylpyridazin-3-one
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C23H26N4O2
 1
1
Ki = 29 nM
   TI
   LI
   LO
   TS
CP0418408
2-methyl-5-[4-(3-piperidin-1-ylpropoxy)phenyl]pyridazin-3-one
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C19H25N3O2
 1
1
Ki = 30 nM
   TI
   LI
   LO
   TS