General Information of the Protein
| Protein ID |
PT04648
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| Protein Name |
Urea transporter 1
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| Secondarily Protein Name |
Solute carrier family 14 member 1
Urea transporter B
Urea transporter
erythrocyte
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| Gene Name |
SLC14A1
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| Secondarily Gene Name |
UT11
UT3
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| Sequence |
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
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| Organism |
Rattus norvegicus, Rat
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| Protein Classification |
Transporter
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Electrochemical transporter
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SLC superfamily of solute carriers
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SLC14 family of facilitative urea transporters
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| Function |
Mediates the transport of urea driven by a concentration gradient across the cell membrane (PubMed:8982255). Mediates the transport of urea across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).
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| Uniprot ID |
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| Ensembl ID | |||||
| Subcellular Location |
Cell membrane
Basolateral cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000031 , MDCK
Similar Protein(s) and Bioactivity Statistics
90% Identity
| Protein ID | Protein Name | Protein Organism | |
| PT03153 | Urea transporter 1 | Mus musculus, Mouse | |
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