Protein Information

General Information of the Protein

Protein ID	PT04639
Protein Name	NPC1-like intracellular cholesterol transporter 1
Secondarily Protein Name	Niemann-Pick C1-like protein 1
Gene Name	NPC1L1
Sequence	MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Other membrane protein
Function	Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed:15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032). May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (PubMed:22095670). Show/Hide
Uniprot ID	Primary ID: Q9UHC9 Secondarily ID: A4D2J7 B7ZLE6 D3DVK9 Q17RV5 Q6R3Q4 Q9UHC8 Show/Hide
Ensembl ID	ENSG00000015520
HGNC ID	HGNC:7898
Subcellular Location	Apical cell membrane Cell membrane Cytoplasmic vesicle membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0415847 Compound Info	N-[(2S)-2-[(3S,5R,6R,8S,9S,10R,13S,14S,17R)-5,6-dihydroxy-10,13-dimethyl-3-(2-morpholin-4-yl-2-oxoethoxy)-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]propyl]-3,5-bis(trifluoromethyl)benzamide Show/Hide	C37H50F6N2O6	1
1	EC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0481959 Compound Info	2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-5,6-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone Show/Hide	C33H57NO5	1
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0555310 Compound Info	(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-3-(2-morpholin-4-yl-2-oxoethoxy)-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one Show/Hide	C33H53NO4	1
1	EC50 = 290 nM Bioactivity Info	TI LI LO TS
CP0539719 Compound Info	2-[[(3S,7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone Show/Hide	C33H55NO4	1
1	EC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0560924 Compound Info	2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-5,6-dihydroxy-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone Show/Hide	C35H59NO5	1
1	EC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0415848 Compound Info	N-[(2S)-2-[(3S,5R,6R,8S,9S,10R,13S,14S,17R)-5,6-dihydroxy-10,13-dimethyl-3-(2-morpholin-4-yl-2-oxoethoxy)-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]propyl]-2-methylpropanamide Show/Hide	C32H54N2O6	1
1	EC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0494598 Compound Info	2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-5,6-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-N,N-bis(2-hydroxyethyl)acetamide Show/Hide	C33H59NO6	1
1	EC50 = 560 nM Bioactivity Info	TI LI LO TS
CP0539720 Compound Info	2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-5,6-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]acetamide Show/Hide	C29H51NO4	1
1	EC50 = 840 nM Bioactivity Info	TI LI LO TS
CP0415849 Compound Info	2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone Show/Hide	C33H55NO4	1
1	EC50 = 880 nM Bioactivity Info	TI LI LO TS
CP0415850 Compound Info	(3S,5R,6R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-3-(2-morpholin-4-ylethoxy)-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-5,6-diol Show/Hide	C33H59NO4	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0488271 Compound Info	2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-N,N-dimethylacetamide Show/Hide	C31H53NO3	1
1	EC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0488014 Compound Info	(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one Show/Hide	C27H44O3	1
1	EC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0317964 Compound Info	3Beta,5Alpha,6Beta-Trihydroxycholestanol Show/Hide	C27H48O3	1
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0427399 Compound Info	(4R)-N,N-diethyl-4-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide Show/Hide	C28H47NO2	1
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0437353 Compound Info	(3S,5R,6R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,5,6-triol Show/Hide	C27H48O4	1
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0510313 Compound Info	(3S,5R,8S,9S,10R,13R,14S,17R)-3,5-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-one Show/Hide	C27H46O3	1
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0574219 Compound Info	2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-5,6-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-1-piperidin-1-ylethanone Show/Hide	C34H59NO4	1
1	EC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0574220 Compound Info	(3S,7R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol Show/Hide	C27H46O3	1
1	EC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0101202 Compound Info	(1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3S)-3-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol Show/Hide	C27H46O2	1
1	EC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0252873 Compound Info	(4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-14-yl]-N,N-dimethylpentanamide Show/Hide	C26H43NO2	1
1	EC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0004096 Compound Info	(1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol Show/Hide	C27H46O2	1
1	EC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0410637 Compound Info	7Beta-Hydroxycholesterol Show/Hide	C27H46O2	1
1	EC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0444211 Compound Info	5alpha-CHOLESTAN-3beta-OL-6-ONE Show/Hide	C27H46O2	1
1	EC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0542158 Compound Info	(3S,7R,8S,9S,10R,13R,14S,17R)-3-(2-hydroxyethoxy)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-7-ol Show/Hide	C29H50O3	1
1	EC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0482079 Compound Info	(8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Show/Hide	C27H44O2	1
1	EC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0548312 Compound Info	(3S,4S,5S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,4,5-triol Show/Hide	C27H48O3	1
1	EC50 = 4300 nM Bioactivity Info	TI LI LO TS
CP0574221 Compound Info	N,N-diethyl-2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]acetamide Show/Hide	C33H57NO3	1
1	EC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0548313 Compound Info	[(3S,7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] morpholine-4-carboxylate Show/Hide	C32H53NO4	1
1	EC50 = 6100 nM Bioactivity Info	TI LI LO TS
CP0542256 Compound Info	3-[(2S)-2-[(3S,5R,6R,8S,9S,10R,13S,14S,17R)-5,6-dihydroxy-10,13-dimethyl-3-(2-morpholin-4-yl-2-oxoethoxy)-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]propyl]-1,1-dimethylurea Show/Hide	C31H53N3O6	1
1	EC50 = 6800 nM Bioactivity Info	TI LI LO TS
CP0379247 Compound Info	7-OXOCHOLESTEROL Show/Hide	C27H44O2	1
1	EC50 = 8700 nM Bioactivity Info	TI LI LO TS
CP0482080 Compound Info	(6R)-6-[(3S,8S,9S,10R,13R,14S,17R)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-2-ol Show/Hide	C33H59NO2	1
1	EC50 = 9900 nM Bioactivity Info	TI LI LO TS
CP0038783 Compound Info	3beta-hydroxyandrost-5-en-17-one Show/Hide	C19H28O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0574222 Compound Info	2-[[(3S,5R,6R,8S,9S,10R,13S,14S,17R)-17-[(2S)-1-[3,5-bis(trifluoromethyl)phenoxy]propan-2-yl]-5,6-dihydroxy-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone Show/Hide	C36H49F6NO6	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0498536 Compound Info	(2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(3-(methylsulfonamido)prop-1-ynyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid Show/Hide	C28H31FN2O11S	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0374285 Compound Info	(2S,3S,4S,5R,6S)-6-(4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-carboxylic acid Show/Hide	C30H29F2NO9	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0540252 Compound Info	(1-(1-naphthoyl)-5-phenylpiperidin-3-yl)(spiro[indene-1,4'-piperidine]-1'-yl)methanone Show/Hide	C36H34N2O2	1
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0407642 Compound Info	2,2,6,6-tetramethylpiperidin-4-yl 2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetate Show/Hide	C37H50N4O4	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0509390 Compound Info	((2S,4S)-1-benzoyl-4-phenylpyrrolidin-2-yl)(spiro[indene-1,4'-piperidine]-1'-yl)methanone Show/Hide	C31H30N2O2	1
1	IC50 = 660 nM Bioactivity Info	TI LI LO TS
CP0520759 Compound Info	ethyl 1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-4-carboxylate Show/Hide	C36H46N4O5	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0466756 Compound Info	tert-butyl 4-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperazine-1-carboxylate Show/Hide	C35H47N5O5	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0501724 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2-hydroxyethyl)acetamide Show/Hide	C28H36N4O4	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0466765 Compound Info	8-(4-cyclohexylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C33H42N4O3	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0527670 Compound Info	8-(4-cyclohexylbenzoyl)-3-(2-(4-(hydroxymethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C34H44N4O4	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0382736 Compound Info	2,2,6,6-tetramethylpiperidin-4-yl 2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetate Show/Hide	C35H48N4O4	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0393235 Compound Info	tert-butyl N-[[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]methyl]carbamate Show/Hide	C34H45N5O5	1
1	IC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0407981 Compound Info	2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2-hydroxyethyl)acetamide Show/Hide	C30H38N4O4	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0466755 Compound Info	2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2-(methylsulfonamido)ethyl)acetamide Show/Hide	C31H41N5O5S	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0345231 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C31H40N4O3	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0437342 Compound Info	tert-butyl N-[[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]methyl]carbamate Show/Hide	C39H53N5O5	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0512844 Compound Info	methyl 4-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]butanoate Show/Hide	C33H42N4O5	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0522285 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(4-(1,3-diethyl-4-methyl-1H-pyrazol-5-yl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C39H52N6O3	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0409998 Compound Info	8-(4-cyclohexylbenzoyl)-3-(2-(3-ethylpiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C35H46N4O3	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0543861 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(4-(2-hydroxyethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C33H44N4O4	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0409995 Compound Info	N-(3-aminopropyl)-2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide Show/Hide	C31H41N5O3	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0520758 Compound Info	ethyl 1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-4-carboxylate Show/Hide	C34H44N4O5	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0520760 Compound Info	1-(2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)piperidine-3-carboxamide Show/Hide	C34H43N5O4	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0543856 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(methylsulfonamidomethyl)acetamide Show/Hide	C28H37N5O5S	1
1	IC50 = 3200 nM Bioactivity Info	TI LI LO TS
CP0518389 Compound Info	1-(2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)-N,N-diethylpiperidine-3-carboxamide Show/Hide	C38H51N5O4	1
1	IC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0466757 Compound Info	tert-butyl 4-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperazine-1-carboxylate Show/Hide	C37H49N5O5	1
1	IC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0407985 Compound Info	8-(4-cyclohexylbenzoyl)-3-(2-(3-methylpiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C34H44N4O3	1
1	IC50 = 3600 nM Bioactivity Info	TI LI LO TS
CP0527667 Compound Info	methyl 2-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]acetate Show/Hide	C31H38N4O5	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0379955 Compound Info	2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(3-(methylsulfonamido)propyl)acetamide Show/Hide	C32H43N5O5S	1
1	IC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0463772 Compound Info	tert-butyl N-[[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]methyl]carbamate Show/Hide	C39H53N5O5	1
1	IC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0527123 Compound Info	N-(2-aminoethyl)-2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide Show/Hide	C30H39N5O3	1
1	IC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0437341 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(3-ethylpiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C33H44N4O3	1
1	IC50 = 3900 nM Bioactivity Info	TI LI LO TS
CP0409999 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(4-(hydroxymethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C32H42N4O4	1
1	IC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0407641 Compound Info	ethyl 1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxylate Show/Hide	C36H46N4O5	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0437339 Compound Info	N-(3-aminopropyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide Show/Hide	C29H39N5O3	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0512846 Compound Info	tert-butyl N-[[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]methyl]carbamate Show/Hide	C37H51N5O5	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0527124 Compound Info	tert-butyl N-[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]carbamate Show/Hide	C36H49N5O5	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0509650 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-isobutylacetamide Show/Hide	C30H40N4O3	1
1	IC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0478959 Compound Info	tert-butyl N-[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]carbamate Show/Hide	C38H51N5O5	1
1	IC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0503862 Compound Info	tert-butyl N-[3-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propyl]carbamate Show/Hide	C34H47N5O5	1
1	IC50 = 4500 nM Bioactivity Info	TI LI LO TS
CP0512843 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(4-(methylsulfonamido)butyl)acetamide Show/Hide	C31H43N5O5S	1
1	IC50 = 4500 nM Bioactivity Info	TI LI LO TS
CP0389827 Compound Info	7-(2-(1-(4-cyclohexylbutyl)-3-(4-(trifluoromethylthio)phenyl)ureido)ethyl)-2-methyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid Show/Hide	C30H37F3N2O5S	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0527688 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(4-(1,3,4-triethyl-1H-pyrazol-5-yl)piperidin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C40H54N6O3	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0543859 Compound Info	tert-butyl N-[4-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]butyl]carbamate Show/Hide	C37H51N5O5	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0473039 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C31H40N4O4	1
1	IC50 = 4700 nM Bioactivity Info	TI LI LO TS
CP0496739 Compound Info	tert-butyl N-[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]carbamate Show/Hide	C38H51N5O5	1
1	IC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0527669 Compound Info	3-(2-(4-benzoylpiperazin-1-yl)-2-oxoethyl)-8-(4-cyclohexylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C39H45N5O4	1
1	IC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0498567 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(4-(1,5-diethyl-4-methyl-1H-pyrazol-3-yl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C39H52N6O3	1
1	IC50 = 5400 nM Bioactivity Info	TI LI LO TS
CP0527678 Compound Info	tert-butyl N-[2-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]ethyl]carbamate Show/Hide	C35H47N5O5	1
1	IC50 = 5500 nM Bioactivity Info	TI LI LO TS
CP0543857 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(5-(methylsulfonamido)pentyl)acetamide Show/Hide	C32H45N5O5S	1
1	IC50 = 5500 nM Bioactivity Info	TI LI LO TS
CP0543858 Compound Info	tert-butyl N-[3-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propyl]carbamate Show/Hide	C36H49N5O5	1
1	IC50 = 6000 nM Bioactivity Info	TI LI LO TS
CP0512845 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(2-(2-hydroxyethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C33H44N4O4	1
1	IC50 = 6100 nM Bioactivity Info	TI LI LO TS
CP0498248 Compound Info	8-(4-cyclohexylbenzoyl)-3-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C33H43N5O5S	1
1	IC50 = 6300 nM Bioactivity Info	TI LI LO TS
CP0523562 Compound Info	3-(2-(4-(3-benzyl-1-ethyl-1H-pyrazol-5-yl)piperidin-1-yl)-2-oxoethyl)-8-(4-tert-butylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C43H52N6O3	1
1	IC50 = 6400 nM Bioactivity Info	TI LI LO TS
CP0473038 Compound Info	8-(4-cyclohexylbenzoyl)-3-(2-oxo-2-(piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C32H41N5O3	1
1	IC50 = 6500 nM Bioactivity Info	TI LI LO TS
CP0528599 Compound Info	N-(2-aminoethyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide Show/Hide	C28H37N5O3	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0505057 Compound Info	4-(4-(((4-tert-butylcyclohexyl)(5-(cyclopentyloxy)-1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)phenoxy)butanoic acid Show/Hide	C34H47N3O4	1
1	IC50 = 7400 nM Bioactivity Info	TI LI LO TS
CP0425653 Compound Info	N-(5-aminopentyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide Show/Hide	C31H43N5O3	1
1	IC50 = 7700 nM Bioactivity Info	TI LI LO TS
CP0379957 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(3-(hydroxymethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C32H42N4O4	1
1	IC50 = 8200 nM Bioactivity Info	TI LI LO TS
CP0501911 Compound Info	ethyl 1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxylate Show/Hide	C34H44N4O5	1
1	IC50 = 8200 nM Bioactivity Info	TI LI LO TS
CP0379954 Compound Info	2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(hydroxymethyl)acetamide Show/Hide	C29H36N4O4	1
1	IC50 = 8300 nM Bioactivity Info	TI LI LO TS
CP0527671 Compound Info	tert-butyl N-[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]carbamate Show/Hide	C36H49N5O5	1
1	IC50 = 8300 nM Bioactivity Info	TI LI LO TS
CP0523418 Compound Info	1-(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)-N,N-diethylpiperidine-3-carboxamide Show/Hide	C36H49N5O4	1
1	IC50 = 8700 nM Bioactivity Info	TI LI LO TS
CP0499515 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(5-hydroxypentyl)acetamide Show/Hide	C31H42N4O4	1
1	IC50 = 9400 nM Bioactivity Info	TI LI LO TS
CP0501910 Compound Info	tert-butyl N-[[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]methyl]carbamate Show/Hide	C37H51N5O5	1
1	IC50 = 9500 nM Bioactivity Info	TI LI LO TS
CP0437340 Compound Info	2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(4-hydroxybutyl)acetamide Show/Hide	C32H42N4O4	1
1	IC50 = 10300 nM Bioactivity Info	TI LI LO TS
CP0503864 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(3-(methylsulfonamido)propyl)acetamide Show/Hide	C30H41N5O5S	1
1	IC50 = 10400 nM Bioactivity Info	TI LI LO TS
CP0473037 Compound Info	tert-butyl N-[2-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]ethyl]carbamate Show/Hide	C33H45N5O5	1
1	IC50 = 10900 nM Bioactivity Info	TI LI LO TS
CP0466754 Compound Info	3-(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetamido)propanoic acid Show/Hide	C29H36N4O5	1
1	IC50 = 11400 nM Bioactivity Info	TI LI LO TS
CP0407986 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(2-(hydroxymethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C32H42N4O4	1
1	IC50 = 11800 nM Bioactivity Info	TI LI LO TS
CP0407984 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(3-methylpiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C32H42N4O3	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0379960 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(3-hydroxypiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C31H40N4O4	1
1	IC50 = 12200 nM Bioactivity Info	TI LI LO TS
CP0376033 Compound Info	methyl 3-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propanoate Show/Hide	C32H40N4O5	1
1	IC50 = 12900 nM Bioactivity Info	TI LI LO TS
CP0532776 Compound Info	tert-butyl N-[5-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]pentyl]carbamate Show/Hide	C36H51N5O5	1
1	IC50 = 13700 nM Bioactivity Info	TI LI LO TS
CP0527122 Compound Info	2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(3-hydroxypropyl)acetamide Show/Hide	C31H40N4O4	1
1	IC50 = 14000 nM Bioactivity Info	TI LI LO TS
CP0409996 Compound Info	8-(4-cyclohexylbenzoyl)-3-(2-oxo-2-(4-(phenylsulfonyl)piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C38H45N5O5S	1
1	IC50 = 14200 nM Bioactivity Info	TI LI LO TS
CP0425652 Compound Info	N-(4-aminobutyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide Show/Hide	C30H41N5O3	1
1	IC50 = 14500 nM Bioactivity Info	TI LI LO TS
CP0407983 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(4-(phenylsulfonyl)piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C36H43N5O5S	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0499550 Compound Info	methyl 2-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]acetate Show/Hide	C29H36N4O5	1
1	IC50 = 16600 nM Bioactivity Info	TI LI LO TS
CP0382734 Compound Info	1-(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)piperidine-3-carboxamide Show/Hide	C32H41N5O4	1
1	IC50 = 16900 nM Bioactivity Info	TI LI LO TS
CP0498247 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C31H41N5O5S	1
1	IC50 = 19000 nM Bioactivity Info	TI LI LO TS
CP0425651 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(4-hydroxybutyl)acetamide Show/Hide	C30H40N4O4	1
1	IC50 = 19200 nM Bioactivity Info	TI LI LO TS
CP0407982 Compound Info	8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C30H39N5O3	1
1	IC50 = 22000 nM Bioactivity Info	TI LI LO TS
CP0528598 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(3-hydroxypropyl)acetamide Show/Hide	C29H38N4O4	1
1	IC50 = 23600 nM Bioactivity Info	TI LI LO TS
CP0503863 Compound Info	N-(aminomethyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide Show/Hide	C27H35N5O3	1
1	IC50 = 26500 nM Bioactivity Info	TI LI LO TS
CP0409994 Compound Info	2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2-(methylsulfonamido)ethyl)acetamide Show/Hide	C29H39N5O5S	1
1	IC50 = 49000 nM Bioactivity Info	TI LI LO TS
CP0393234 Compound Info	tert-butyl N-[[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]methyl]carbamate Show/Hide	C32H43N5O5	1
1	IC50 = 59000 nM Bioactivity Info	TI LI LO TS
CP0540247 Compound Info	2-phenylethyl 1-[(4-tert-butylbenzoyl)sulfamoyl]spiro[2H-indole-3,4'-piperidine]-1'-carboxylate Show/Hide	C32H37N3O5S	1
1	IC50 = 79000 nM Bioactivity Info	TI LI LO TS
CP0505062 Compound Info	benzyl 2-[2-(4-methylphenyl)ethyl]-5-[(1H-pyrazole-4-carbonylamino)methyl]piperidine-1-carboxylate Show/Hide	C27H32N4O3	1
1	IC50 = 81000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000036 , MDCK-II

Cell Line Info

Clinical Information about the Protein

Target 1 ( Niemann-Pick C1-like protein 1 (NPC1L1) )

Target Type	Successful Target
Disease	1 Target-related Disease				1
1	Hypercholesterolaemia [ICD-11: 5C80.0]
Approved Drug(s)	1 Approved Drug				1
1	Ezetimibe	Drug Info	Approved	Hypercholesterolaemia

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han