General Information of the Protein
Protein ID
PT04438
Protein Name
Toll-like receptor 2
Secondarily
Protein Name
Toll/interleukin-1 receptor-like protein 4
Gene Name
TLR2
Secondarily
Gene Name
TIL4
Sequence
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Toll-like and Il-1 receptors
Function
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).
    Show/Hide
Uniprot ID
Primary ID:
O60603

Secondarily ID:
B3Y612
D1CS45
D1CS48
D1CS49
O15454
Q8NI00
    Show/Hide
HGNC ID
HGNC:11848
Subcellular Location
Membrane
Cytoplasmic vesicle
Phagosome membrane
Membrane raft
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0392622
 Compound Info 
[(2R)-3-[(2R)-2-amino-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]selanyl-2-hexadecanoyloxypropyl] hexadecanoate
   Show/Hide
C42H80N2O8Se
  1
1
EC50 = 0.26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475439
 Compound Info 
[(2R)-3-[(2R)-2-amino-3-oxo-3-[(2-oxo-2-propan-2-yloxyethyl)amino]propyl]sulfanyl-2-hexadecanoyloxypropyl] hexadecanoate
   Show/Hide
C43H82N2O7S
  1
1
EC50 = 0.45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524914
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-2,3-di(tetradecanoyloxy)propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C37H70N2O8S
  1
1
EC50 = 0.56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524913
 Compound Info 
[(2R)-3-[(2R)-2-amino-3-oxo-3-[(2-oxo-2-propan-2-yloxyethyl)amino]propyl]sulfanyl-2-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]oxypropyl] (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
   Show/Hide
C47H78N2O7S
  1
1
EC50 = 0.87 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0495450
 Compound Info 
[(2R)-3-[(2R)-2-amino-3-oxo-3-[(2-oxo-2-propan-2-yloxyethyl)amino]propyl]sulfanyl-2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] (9Z,12Z)-octadeca-9,12-dienoate
   Show/Hide
C47H82N2O7S
  1
1
EC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0424087
 Compound Info 
2-[(2R)-2-acetamido-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanylethyl hexadecanoate
   Show/Hide
C27H50N2O7S
  1
1
EC50 = 1.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0523714
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-2,3-di(octadecanoyloxy)propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C45H86N2O8S
  1
1
EC50 = 1.47 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400465
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-3-[2-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propylamino]acetyl]oxy-2-hexadecanoyloxypropyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C37H72N4O11S
  1
1
EC50 = 1.55 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0424194
 Compound Info 
2-[(2R)-2-(butanoylamino)-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanylethyl hexadecanoate
   Show/Hide
C29H54N2O7S
  1
1
EC50 = 1.64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400466
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-2-hexadecanoyloxy-3-hydroxypropyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C25H48N2O7S
  1
1
EC50 = 1.86 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0427982
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-3-hexadecanoyloxy-2-hydroxypropyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C25H48N2O7S
  1
1
EC50 = 1.95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399408
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-3-[2-[3-[2-(2-ethoxyethoxy)ethoxy]propylamino]acetyl]oxy-2-hexadecanoyloxypropyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C36H69N3O11S
  1
1
EC50 = 2.11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0456616
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-3-[2-[3-[4-(3-aminopropylamino)butylamino]propylamino]acetyl]oxy-2-hexadecanoyloxypropyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C37H74N6O8S
  1
1
EC50 = 3.23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392621
 Compound Info 
2-[(2R)-2-amino-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanylethyl hexadecanoate
   Show/Hide
C25H48N2O6S
  2
1
EC50 = 3.63 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 4.44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0012622
 Compound Info 
(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid
   Show/Hide
C65H126N10O12S
  1
1
EC50 = 3.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0417508
 Compound Info 
2-[(2R)-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-2-(octanoylamino)-3-oxopropyl]sulfanylethyl hexadecanoate
   Show/Hide
C33H62N2O7S
  1
1
EC50 = 3.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0482141
 Compound Info 
2-[(2R)-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxo-2-[(2,2,2-trifluoroacetyl)amino]propyl]sulfanylethyl hexadecanoate
   Show/Hide
C27H47F3N2O7S
  1
1
EC50 = 4.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0417509
 Compound Info 
2-[(2R)-2-amino-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanylethyl octadecanoate
   Show/Hide
C27H52N2O6S
  1
1
EC50 = 4.79 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0417507
 Compound Info 
3-[(2R)-2-acetamido-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanylpropyl hexadecanoate
   Show/Hide
C28H52N2O7S
  1
1
EC50 = 5.52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0462012
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-2,3-di(dodecanoyloxy)propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C33H62N2O8S
  1
1
EC50 = 6.48 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0453964
 Compound Info 
[(2R)-3-[(2R)-2-[[2-[2-[3-[2-[2-(3-acetamidopropoxy)ethoxy]ethoxy]propylamino]-2-oxoethoxy]acetyl]amino]-3-[[2-[[(2R)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-oxopropyl]sulfanyl-2-hexadecanoyloxypropyl] hexadecanoate
   Show/Hide
C73H136N8O21S
  2
1
EC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0012431
 Compound Info 
(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-2-(hexadecanoylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid
   Show/Hide
C81H156N10O13S
  1
1
EC50 = 23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0491722
 Compound Info 
(4R)-4-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[2-[2-[3-[2-[2-(3-acetamidopropoxy)ethoxy]ethoxy]propylamino]-2-oxoethoxy]acetyl]amino]-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-5-amino-5-oxopentanoic acid
   Show/Hide
C100H168N16O32S
  1
1
EC50 = 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0883709
 Compound Info 
2-((1E,3E,5Z)-5-(1-(6-(2-(3-((22R,28R)-1-amino-28-(((R)-2,3-bis(palmitoyloxy)propylthio)methyl)-22-(hydroxymethyl)-1,5,21,24,27,30,34,50-octaoxo-3,10,13,16,32,39,42,45-octaoxa-6,20,23,26,29,35,49-heptaazadopentacontan-52-ylthio)-2,5-dioxopyrrolidin-1-yl)ethylamino)-6-oxohexyl)-5-sulfonatoindolin-2-ylidene)penta-1,3-dienyl)-1-ethyl-3H-indolium-5-sulfonate
   Show/Hide
C109H176N12O30S4
  2
1
EC50 = 34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0446213
 Compound Info 
[(2R)-3-[(2R)-3-[[2-[[(2R)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-oxo-2-[[2-[2-oxo-2-[3-[2-[2-[3-(3-sulfanylpropanoylamino)propoxy]ethoxy]ethoxy]propylamino]ethoxy]acetyl]amino]propyl]sulfanyl-2-hexadecanoyloxypropyl] hexadecanoate
   Show/Hide
C74H138N8O21S2
  1
1
EC50 = 39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0525516
 Compound Info 
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[2-[2-[3-[2-[2-(3-acetamidopropoxy)ethoxy]ethoxy]propylamino]-2-oxoethoxy]acetyl]amino]-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]acetyl]amino]-4-amino-4-oxobutanoyl]amino]-4-amino-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-6-aminohexanoyl]amino]-5-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-5-oxopentanoic acid
   Show/Hide
C115H196N22O36S
  1
1
EC50 = 56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0492143
 Compound Info 
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[2-[2-[3-[2-[2-(3-acetamidopropoxy)ethoxy]ethoxy]propylamino]-2-oxoethoxy]acetyl]amino]-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-amino-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-5-amino-5-oxopentanoic acid
   Show/Hide
C96H170N16O30S
  1
1
EC50 = 78 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0466462
 Compound Info 
7-fluoro-4-hydroxy-12-methyl-2-oxo-N-(pyridin-3-ylmethyl)-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraene-3-carboxamide
   Show/Hide
C20H18FN3O3
  1
1
EC50 = 1350 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0438170
 Compound Info 
7-fluoro-4-hydroxy-12-methyl-2-oxo-N-(2-pyridin-3-ylethyl)-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraene-3-carboxamide
   Show/Hide
C21H20FN3O3
  1
1
EC50 = 1860 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0578847
 Compound Info 
N-[[2-(dimethylamino)pyridin-3-yl]methyl]-7-fluoro-4-hydroxy-12-methyl-2-oxo-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraene-3-carboxamide
   Show/Hide
C22H23FN4O3
  1
1
EC50 = 3090 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455857
 Compound Info 
7-fluoro-N-[(5-fluoropyridin-3-yl)methyl]-4-hydroxy-12-methyl-2-oxo-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraene-3-carboxamide
   Show/Hide
C20H17F2N3O3
  1
1
EC50 = 4520 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455856
 Compound Info 
N-[(6-aminopyridin-3-yl)methyl]-7-fluoro-4-hydroxy-12-methyl-2-oxo-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraene-3-carboxamide
   Show/Hide
C20H19FN4O3
  1
1
EC50 = 7560 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399409
 Compound Info 
[(2R)-2-hexadecanoyloxy-3-[3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanylpropyl] hexadecanoate
   Show/Hide
C42H79NO8S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400467
 Compound Info 
3-[(2R)-2-amino-3-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-3-oxopropyl]sulfanylpropyl hexadecanoate
   Show/Hide
C26H50N2O6S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400468
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-3-methylbutanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C43H82N2O8S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0427981
 Compound Info 
(2S)-2-[[(2R)-2-amino-3-[(2R)-2,3-bis[[2-[3-[2-(2-ethoxyethoxy)ethoxy]propylamino]acetyl]oxy]propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C31H60N4O14S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475440
 Compound Info 
methyl (2S)-2-[[(2R)-2-amino-3-(2-hexadecoxy-2-oxoethyl)sulfanylpropanoyl]amino]-3-hydroxypropanoate
   Show/Hide
C25H48N2O6S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475441
 Compound Info 
methyl (2S)-2-[[(2R)-2-amino-3-(3-hexadecoxy-3-oxopropyl)sulfanylpropanoyl]amino]-3-hydroxypropanoate
   Show/Hide
C26H50N2O6S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476230
 Compound Info 
(2S)-2-amino-5-[[(2R)-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxo-1-[(2-oxo-2-propan-2-yloxyethyl)amino]propan-2-yl]amino]-5-oxopentanoic acid
   Show/Hide
C48H89N3O10S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476231
 Compound Info 
(2S)-2-[[(2S)-2-amino-4-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylbutanoyl]amino]-3-hydroxypropanoic acid
   Show/Hide
C42H80N2O8S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524915
 Compound Info 
[(2R)-3-[(3S)-3-amino-4-[[(2S)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]amino]-2-methyl-4-oxobutan-2-yl]sulfanyl-2-hexadecanoyloxypropyl] hexadecanoate
   Show/Hide
C44H84N2O8S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475980
 Compound Info 
3-[2-[[(2S)-3-[[(3R)-3-dodecanoyloxydecyl]amino]-3-oxo-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acid
   Show/Hide
C51H90N3O12P
  1
1
IC50 = 900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483469
 Compound Info 
3-[2-[[(2S)-3-[(3R)-3-dodecanoyloxydecoxy]-3-oxo-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acid
   Show/Hide
C51H89N2O13P
  1
1
IC50 = 950 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0485669
 Compound Info 
3-[2-[[(2R)-3-[(3R)-3-dodecanoyloxydecoxy]-2-tetradecanoyloxypropoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acid
   Show/Hide
C51H90NO13P
  1
1
IC50 = 1250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419503
 Compound Info 
[(3R)-1-[(2R)-3-[hydroxy-[2-[3-(4-hydroxyphenyl)propanoylamino]ethoxy]phosphoryl]oxy-2-(tetradecanoylamino)propoxy]decan-3-yl] dodecanoate
   Show/Hide
C50H91N2O10P
  1
1
IC50 = 2150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0141465
 Compound Info 
1-pentyl-4-(2-phenylmethoxyphenyl)imidazol-2-amine;hydrochloride
   Show/Hide
C21H26ClN3O
  1
1
IC50 = 2400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432587
 Compound Info 
3-[2-[[(2R)-3-[(3R)-3-dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acid
   Show/Hide
C51H91N2O12P
  1
1
IC50 = 3070 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0522280
 Compound Info 
3-[2-[[(2R)-3-[(3R)-3-(dodecanoylamino)decoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acid
   Show/Hide
C51H92N3O11P
  1
1
IC50 = 5200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0436647
 Compound Info 
3-[2-[[(2R)-3-[(3S)-3-dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acid
   Show/Hide
C51H91N2O12P
  1
1
IC50 = 6460 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0428287
 Compound Info 
3-[2-[[(2S)-3-[(3S)-3-dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acid
   Show/Hide
C51H91N2O12P
  1
1
IC50 = 6900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475981
 Compound Info 
3-[2-[[(2S)-3-[(3R)-3-dodecanoyloxydecoxy]-2-(tetradecanoylamino)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-[(4-hydroxyphenyl)methyl]-3-oxopropanoic acid
   Show/Hide
C51H91N2O12P
  1
1
IC50 = 22000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000255 , H5
 Cell Line Info 
Cell Line ID: CL000546 , HEK-Blue hTLR2
 Cell Line Info 
Cell Line ID: CL000870 , HEK-Blue Null1-v
 Cell Line Info 
Cell Line ID: CL000752 , PBMC iPSC #1
 Cell Line Info 
Cell Line ID: CL000687 , SU.86.86
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0012622
 Compound Info 
(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid
   Show/Hide
C65H126N10O12S
  1
1 IC50 = 426.3 nM
Clinical Information about the Protein
Target 1 ( Toll-like receptor 2 (TLR2) )
Target Type Clinical trial Target
Target 2 ( HUMAN toll-like receptor 2 (TLR2) )
Target Type Unknown Type Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT03141 Toll-like receptor 2 Mus musculus, Mouse
 Protein Info