General Information of the Protein
| Protein ID |
PT04401
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| Protein Name |
Sodium/hydrogen exchanger 2
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| Secondarily Protein Name |
Na(+)/H(+) exchanger 2
Solute carrier family 9 member 2
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| Gene Name |
SLC9A2
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| Secondarily Gene Name |
NHE2
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| Sequence |
MESAGTGRSLRTPPPRLLLLLLLQVAGPAGALAETLLNAPKAMGTSSSPLSPASVVAPGTTAFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENLGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTRVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESIRKDNSLNRERRASTSTSRYLSLPKNTKLPEKLQKRKNISNADGDSSDSEADAGTTVLNLQPRARRFLPEPFSKKASQAYKMEWKNEVDAGSGQGQPSPPAAPRSKEGGTQTPAVLRQPLLSKDQGREDSLTEGGRPKPPPRLVRRASEPGNRKSRLGSDKP
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| Organism |
Oryctolagus cuniculus, Rabbit
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| Protein Classification |
Transporter
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Electrochemical transporter
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SLC superfamily of solute carriers
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SLC09 family of sodium/hydrogen exchangers
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| Function |
Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:7685025, PubMed:9612213). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity).
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| Uniprot ID | |||||
| Ensembl ID | |||||
| Subcellular Location |
Apical cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000658 , LAP1
Biochemical Assays
Similar Protein(s) and Bioactivity Statistics
50% Identity
| Protein ID | Protein Name | Protein Organism | |
| PT04308 | Sodium/hydrogen exchanger 2 | Homo sapiens, Human | |
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