General Information of the Protein
Protein ID
PT04172
Protein Name
Thioredoxin reductase 1, cytoplasmic
Secondarily
Protein Name
Gene associated with retinoic and interferon-induced mortality 12 protein
KM-102-derived reductase-like factor
Peroxidase TXNRD1
Thioredoxin reductase TR1
Gene Name
TXNRD1
Secondarily
Gene Name
GRIM12
KDRF
Sequence
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
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Uniprot ID
Primary ID:
Q16881

Secondarily ID:
B7Z1F4
B7Z3Y8
B7Z904
E9PMY9
F5H780
Q6FI31
Q6VB40
Q6VB41
Q6VB42
Q6VBP2
Q6VBP3
Q6VBP4
Q6VBP5
Q6VBP9
Q6VBQ0
Q6YNQ1
Q76P53
Q7LA96
Q8WVC8
Q99475
Q9UES8
Q9UH79
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Ensembl ID
ENSG00000198431
HGNC ID
HGNC:12437
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000400 , BEL-7402/5-FU
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0479957
 Compound Info 
(6E)-6-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enylidene]cyclohex-2-en-1-one
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C16H16O3
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0492242
 Compound Info 
(6E)-6-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]cyclohex-2-en-1-one
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C17H19NO
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0486591
 Compound Info 
(6E)-6-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]cyclohex-2-en-1-one
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C16H16O2
  1
1
IC50 = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0564713
 Compound Info 
(6E)-6-[(E)-3-(4-fluorophenyl)prop-2-enylidene]cyclohex-2-en-1-one
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C15H13FO
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0040187
 Compound Info 
CHEBI:8241
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C17H19NO5
  1
1
IC50 = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000004 , SH-SY5Y
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0563588
 Compound Info 
(E)-N-[2-(tert-butylamino)-1-(4-methoxyphenyl)-2-oxoethyl]-4-(4-methylphenyl)-4-oxo-N-propan-2-ylbut-2-enamide
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C27H34N2O4
  1
1 IC50 = 760 nM
CP0358695
 Compound Info 
(E)-N-[2-(tert-butylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-cyclopropyl-4-(4-fluorophenyl)-4-oxobut-2-enamide
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C25H26F2N2O3
  1
1 IC50 = 820 nM
CP0096608
 Compound Info 
2-[[2-(tert-butylamino)-1-(4-fluorophenyl)-2-oxoethyl]-methylamino]ethyl (E)-4-(4-fluorophenyl)-4-oxobut-2-enoate
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C25H28F2N2O4
  1
1 IC50 = 960 nM
CP0060423
 Compound Info 
(E)-N-[2-(tert-butylamino)-2-oxo-1-(3,4,5-trimethoxyphenyl)ethyl]-4-(4-fluorophenyl)-N-(3-methylbutyl)-4-oxobut-2-enamide
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C30H39FN2O6
  1
1 IC50 = 2510 nM
CP0096609
 Compound Info 
(E)-N-cyclohexyl-N-[2-(cyclohexylamino)-1-(2-methoxyphenyl)-2-oxoethyl]-4-(4-methylphenyl)-4-oxobut-2-enamide
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C32H40N2O4
  1
1 IC50 = 5280 nM
CP0176626
 Compound Info 
(E)-N-[2-(benzylamino)-1-(5-methylpyrimidin-2-yl)-2-oxoethyl]-N-cyclopropyl-4-(4-methylphenyl)-4-oxobut-2-enamide
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C28H28N4O3
  1
1 IC50 = 6610 nM
Clinical Information about the Protein
Target 1 ( Cytoplasmic thioredoxin reductase (TXNRD1) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Plaque psoriasis [ICD-11: EA90.0]
2 Malaria [ICD-11: 1F40-1F45]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Spermidine
 Drug Info 
Phase 3
Plaque psoriasis
Investigative Drug(s) 1 Investigative Drug  1
1 5,8-Dihydroxy-1,4-naphthoquinone
 Drug Info 
Investigative
Malaria