General Information of the Protein
Protein ID
PT04148
Protein Name
P2X purinoceptor 2
Secondarily
Protein Name
ATP receptor
Purinergic receptor
Gene Name
P2RX2
Secondarily
Gene Name
P2X2
Sequence
MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
P2X receptor
Function
Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
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Uniprot ID
Primary ID:
Q9UBL9

Secondarily ID:
A6NGB4
A6NH93
A6NHC2
A6NHU3
A6NIG9
Q6V9R6
Q9NR37
Q9NR38
Q9UHD5
Q9UHD6
Q9UHD7
Q9Y637
Q9Y638
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HGNC ID
HGNC:15459
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000094 , 1321N1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0548426
 Compound Info 
N-[(3,5-dichloro-4-hydroxyphenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
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C15H10Cl2N2O4S
  4
1
EC50 = 8270 nM
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2
EC50 = 10780 nM
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3
EC50 = 10880 nM
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4
IC50 = 247 nM
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CP0577060
 Compound Info 
N-[(4-nitrophenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
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C15H11N3O5S
  1
1
IC50 = 634 nM
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CP0849076
 Compound Info 
Disodium 1-Amino-4-[3-(4,6-dichloro[1,3,5]triazine-2-ylamino)-4-sulfophenylamino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
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C23H12Cl2N6Na2O8S2
  2
1
IC50 = 690 nM
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2
IC50 = 692 nM
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CP0569002
 Compound Info 
N-[(3,4-dimethoxyphenyl)carbamothioyl]adamantane-1-carboxamide
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C20H26N2O3S
  1
1
IC50 = 732 nM
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CP0545082
 Compound Info 
1-amino-4-[4-[[4-chloro-6-(3-sulfinoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid
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C29H20ClN7O10S3
  1
1
IC50 = 890 nM
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CP0577518
 Compound Info 
N-[(3,5-dichloro-4-hydroxyphenyl)carbamothioyl]adamantane-1-carboxamide
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C18H20Cl2N2O2S
  1
1
IC50 = 1061 nM
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CP0545085
 Compound Info 
4-[[3-formyl-4-hydroxy-5-methyl-2-(phosphonooxymethyl)phenyl]diazenyl]benzene-1,3-disulfonic acid
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C15H15N2O12PS2
  1
1
IC50 = 1400 nM
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CP0548430
 Compound Info 
N-[(2-hydroxyphenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
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C15H12N2O4S
  1
1
IC50 = 1424 nM
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CP0108374
 Compound Info 
CHEBI:34941
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C14H14N3O12PS2
  1
1
IC50 = 2020 nM
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CP0548431
 Compound Info 
N-[(3-hydroxyphenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
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C15H12N2O4S
  1
1
IC50 = 2086 nM
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CP0545083
 Compound Info 
N-[(3-methoxyphenyl)carbamothioyl]adamantane-1-carboxamide
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C19H24N2O2S
  1
1
IC50 = 2306 nM
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CP0545078
 Compound Info 
N-[(2-chloro-5-nitrophenyl)carbamothioyl]adamantane-1-carboxamide
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C18H20ClN3O3S
  1
1
IC50 = 4576 nM
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CP0578532
 Compound Info 
N-[(2-bromo-4-methylphenyl)carbamothioyl]adamantane-1-carboxamide
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C19H23BrN2OS
  1
1
IC50 = 4852 nM
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CP0546360
 Compound Info 
N-[(4-methoxyphenyl)carbamothioyl]adamantane-1-carboxamide
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C19H24N2O2S
  1
1
IC50 = 5242 nM
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CP0569984
 Compound Info 
N-[(4-hydroxyphenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
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C15H12N2O4S
  1
1
IC50 = 6430 nM
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CP0430000
 Compound Info 
5-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxycarbonyl]benzene-1,2,4-tricarboxylic acid
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C23H21N5O11
  1
1
IC50 > 10000 nM
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CP0072340
 Compound Info 
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
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C15H8ClF6NO2
  1
1
IC50 > 10000 nM
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CP0387003
 Compound Info 
5-chloro-2-hydroxy-N-[3-nitro-5-(trifluoromethyl)phenyl]benzamide
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C14H8ClF3N2O4
  1
1
IC50 > 10000 nM
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CP0387004
 Compound Info 
N-[3,5-bis(trifluoromethyl)phenyl]-3-fluoro-2-hydroxybenzamide
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C15H8F7NO2
  1
1
IC50 > 10000 nM
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CP0402500
 Compound Info 
N-[3,5-bis(trifluoromethyl)phenyl]-1-hydroxynaphthalene-2-carboxamide
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C19H11F6NO2
  1
1
IC50 > 10000 nM
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CP0410779
 Compound Info 
5-chloro-N-(3,5-dichlorophenyl)-2-hydroxybenzamide
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C13H8Cl3NO2
  1
1
IC50 > 10000 nM
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CP0472734
 Compound Info 
N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxybenzamide
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C15H9F6NO2
  1
1
IC50 > 10000 nM
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CP0472736
 Compound Info 
5-chloro-N-(3-chlorophenyl)-2-hydroxybenzamide
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C13H9Cl2NO2
  1
1
IC50 > 10000 nM
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CP0472737
 Compound Info 
5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide
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C14H9ClF3NO2
  1
1
IC50 > 10000 nM
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CP0479699
 Compound Info 
N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide
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C15H8ClF6NO2
  1
1
IC50 > 10000 nM
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CP0479706
 Compound Info 
5-chloro-N-(3,5-difluorophenyl)-2-hydroxybenzamide
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C13H8ClF2NO2
  1
1
IC50 > 10000 nM
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CP0479707
 Compound Info 
5-chloro-2-hydroxy-N-[4-(trifluoromethyl)phenyl]benzamide
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C14H9ClF3NO2
  1
1
IC50 > 10000 nM
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CP0487340
 Compound Info 
N-[3,5-bis(trifluoromethyl)phenyl]-3-chloro-2-hydroxybenzamide
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C15H8ClF6NO2
  1
1
IC50 > 10000 nM
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CP0014670
 Compound Info 
CHEMBL3040216
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C51H40N6O23S6
  2
1
IC50 = 13450 nM
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2
IC50 = 14050 nM
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CP0564477
 Compound Info 
N-[(2-chloropyridin-3-yl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
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C14H10ClN3O3S
  1
1
IC50 = 35870 nM
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CP0054492
 Compound Info 
benzo[b][1]benzazepin-11-yl(pyrrolidin-1-yl)methanone
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C19H18N2O
  1
1
IC50 > 100000 nM
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CP0054493
 Compound Info 
N,N-dipropylbenzo[b][1]benzazepine-11-carboxamide
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C21H24N2O
  1
1
IC50 > 100000 nM
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CP0134749
 Compound Info 
N,N-diethylbenzo[b][1]benzazepine-11-carboxamide
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C19H20N2O
  1
1
IC50 > 100000 nM
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CP0167727
 Compound Info 
benzo[b][1]benzazepin-11-yl(piperidin-1-yl)methanone
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C20H20N2O
  1
1
IC50 > 100000 nM
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CP0246924
 Compound Info 
N-cyclohexylbenzo[b][1]benzazepine-11-carboxamide
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C21H22N2O
  1
1
IC50 > 100000 nM
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CP0246925
 Compound Info 
N,N-di(propan-2-yl)benzo[b][1]benzazepine-11-carboxamide
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C21H24N2O
  1
1
IC50 > 100000 nM
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CP0149500
 Compound Info 
[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)spiro[3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-2,1'-cyclohexane]-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C16H36N9O13P3
  1
1
IC50 > 100000 nM
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CP0149504
 Compound Info 
[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)spiro[3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-2,1'-cyclohexane]-6-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid;azane
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C17H38N9O12P3
  1
1
IC50 > 100000 nM
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CP0232343
 Compound Info 
[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C13H32N9O13P3
  1
1
IC50 > 100000 nM
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CP0347185
 Compound Info 
[[(2S,3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2-phenyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C17H32N9O13P3
  1
1
IC50 > 100000 nM
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CP0429999
 Compound Info 
[[(2R,3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2-phenyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C17H32N9O13P3
  1
1
IC50 > 100000 nM
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CP0487903
 Compound Info 
[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C11H28N9O13P3
  1
1
IC50 > 100000 nM
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CP0493771
 Compound Info 
(2S)-2-[[(3aR,4R,6S,6aS)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-6-carbonyl]amino]pentanedioic acid
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C18H22N6O8
  1
1
IC50 > 100000 nM
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Cell Line ID: CL000093 , C6-BU-1
 Cell Line Info 
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0031968
 Compound Info 
3-[4-(3-chloro-4-propan-2-yloxyanilino)-3-[(4-methylphenyl)methyl]-2,6-dioxo-1,3,5-triazin-1-yl]propanoic acid
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C23H25ClN4O5
  1
1 IC50 > 30000 nM