General Information of the Protein
Protein ID
PT04137
Protein Name
Kallikrein-8
Secondarily
Protein Name
Neuropsin
Ovasin
Serine protease 19
Serine protease TADG-14
Tumor-associated differentially expressed gene 14 protein
Gene Name
KLK8
Secondarily
Gene Name
NRPN
PRSS19
TADG14
UNQ283/PRO322
Sequence
MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGSKG
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease PA clan
>
Serine protease S1A subfamily
Function
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
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Uniprot ID
Primary ID:
O60259

Secondarily ID:
Q5V9X1
Q5V9X2
Q8IW69
Q9HCB3
Q9NR68
Q9NR69
Q9UIL9
Q9UQ47
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Ensembl ID
ENSG00000129455
HGNC ID
HGNC:6369
Subcellular Location
Secreted
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000265 , NS0
Compound ID Compound Name Compound Formula
CP0164331
4-[(3R)-1-hydroxy-7-(trifluoromethyl)-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C22H20BClF3N3O3
 1
1
IC50 = 6.31 nM
   TI
   LI
   LO
   TS
CP0438055
4-[1-hydroxy-7-(trifluoromethyl)-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C22H20BClF3N3O3
 1
1
IC50 = 25.12 nM
   TI
   LI
   LO
   TS
CP0360971
4-[(3S)-1-hydroxy-7-(trifluoromethyl)-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C22H20BClF3N3O3
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0239863
2-[(3-chlorophenyl)methoxy]-4-(1-hydroxy-3,4-dihydro-2,1-benzoxaborinin-3-yl)benzenecarboximidamide;hydrochloride
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C22H21BCl2N2O3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0239864
4-[(1-hydroxy-3H-2,1-benzoxaborol-3-yl)methyl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C21H21BClN3O3
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0250361
2-[(2-chlorophenyl)methoxy]-4-(1-hydroxy-3,4-dihydro-2,1-benzoxaborinin-3-yl)benzenecarboximidamide;hydrochloride
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C22H21BCl2N2O3
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0354490
4-(6-chloro-7-fluoro-1-hydroxy-3,4-dihydro-2,1-benzoxaborinin-3-yl)-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C21H19BCl2FN3O3
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0477255
4-[(6-fluoro-1-hydroxy-3H-2,1-benzoxaborol-3-yl)methyl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C21H20BClFN3O3
 1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CP0360969
4-(1-hydroxy-3,4-dihydro-2,1-benzoxaborinin-3-yl)-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C21H21BClN3O3
 1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0063723
4-[(5-phenyl-1H-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide
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C23H22N6O
 1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0354488
4-(1-hydroxy-8-methyl-3,4-dihydro-2,1-benzoxaborinin-3-yl)-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C22H23BClN3O3
 1
1
IC50 = 1584.89 nM
   TI
   LI
   LO
   TS
CP0340135
4-[[1-hydroxy-6-(trifluoromethyl)-3H-2,1-benzoxaborol-3-yl]methyl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C22H20BClF3N3O3
 1
1
IC50 = 1995.26 nM
   TI
   LI
   LO
   TS
CP0477254
4-(7-fluoro-1-hydroxy-3,4-dihydro-2,1-benzoxaborinin-3-yl)-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C21H20BClFN3O3
 1
1
IC50 = 7943.28 nM
   TI
   LI
   LO
   TS
CP0360970
4-[(1-hydroxy-5-methyl-3H-2,1-benzoxaborol-3-yl)methyl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C22H23BClN3O3
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0239865
4-[(1-hydroxy-5-methoxy-3H-2,1-benzoxaborol-3-yl)methyl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C22H23BClN3O4
 1
1
IC50 = 12589.25 nM
   TI
   LI
   LO
   TS
CP0340136
4-[(5-fluoro-1-hydroxy-3H-2,1-benzoxaborol-3-yl)methyl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide;hydrochloride
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C21H20BClFN3O3
 1
1
IC50 = 12589.25 nM
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Neuropsin (KLK8) )
Target Type Literature-reported Target