General Information of the Protein
Protein ID
PT04000
Protein Name
Integrin alpha-1
Secondarily
Protein Name
CD49 antigen-like family member A
Laminin and collagen receptor
VLA-1
Gene Name
ITGA1
Sequence
MAPRPRARPGVAVACCWLLTVVLRCCVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKNRTGDVYKCPVGRGESLPCVKLDLPVNTSIPNVTEVKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVQECSTQLDIVIVLDGSNSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKASQIIIPRNTTFNVESTKKNEPLASYLGYTVNSATASSGDVLYIAGQPRYNHTGQVIIYRMEDGNIKILQTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQMSLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIYHGSGKTIRKEYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVAVVKVTMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLDSLRQISRSFFSGTQERKVQRNITVRKSECTKHSFYMLDKHDFQDSVRITLDFNLTDPENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKFNVSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHNITCKVGYPFLRRGEMVTFKILFQFNTSYLMENVTIYLSATSDSEEPPETLSDNVVNISIPVKYEVGLQFYSSASEYHISIAANETVPEVINSTEDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPTGLSSSENANCRPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDISQVNVSLILWKPTFIKSYFSSLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
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Uniprot ID
Primary ID:
P56199

Secondarily ID:
B2RNU0
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Ensembl ID
ENSG00000213949
HGNC ID
HGNC:6134
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0904066
 Compound Info 
4-benzoylphenyl-3,5-dichloro-2-hydroxybenzenesulfonate
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C19H12Cl2O5S
  1
1
EC50 = 11000 nM
 Bioactivity Info 
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CP0857548
 Compound Info 
N-(3-benzoylphenyl)-4-bromobenzenesulfonamide
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C19H14BrNO3S
  1
1
EC50 = 16000 nM
 Bioactivity Info 
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CP0850070
 Compound Info 
N-3-benzoylphenyl-2,4-dichlorobenzenesulfonamide
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C19H13Cl2NO3S
  1
1
EC50 = 17000 nM
 Bioactivity Info 
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CP0849426
 Compound Info 
N-(9H-fluoren-2-yl)-2,4-dichlorobenzenesulfonamide
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C19H13Cl2NO2S
  1
1
EC50 = 19000 nM
 Bioactivity Info 
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CP0849425
 Compound Info 
N-4-benzoylphenyl-2,4-dichlorobenzenesulfonamide
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C19H13Cl2NO3S
  1
1
EC50 = 20000 nM
 Bioactivity Info 
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CP0857547
 Compound Info 
N-(9-oxo-9H-fluoren-2-yl)-2,4dichlorobenzenesulfonamide
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C19H11Cl2NO3S
  1
1
EC50 = 20000 nM
 Bioactivity Info 
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CP0916679
 Compound Info 
N-(4-benzoylphenyl)-4-iodobenzenesulfonamide
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C19H14INO3S
  1
1
EC50 = 22000 nM
 Bioactivity Info 
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CP0955143
 Compound Info 
N-(3-benzoylphenyl)-4-iodobenzenesulfonamide
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C19H14INO3S
  1
1
EC50 = 40000 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( Integrin alpha-1 (VLA-1) )
Target Type Clinical trial Target