General Information of the Protein
| Protein ID |
PT03954
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| Protein Name |
Calmodulin-sensitive adenylate cyclase
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| Secondarily Protein Name |
ATP pyrophosphate-lyase
Adenylyl cyclase
Anthrax edema toxin adenylate cyclase component
Edema factor
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| Gene Name |
CYA
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| Secondarily Gene Name |
pXO1-122
BXA0141
GBAA_pXO1_0142
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| Sequence |
MTRNKFIPNKFSIISFSVLLFAISSSQAIEVNAMNEHYTESDIKRNHKTEKNKTEKEKFKDSINNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIIDEK
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| Organism |
Bacillus anthracis
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| Protein Classification |
Enzyme
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| Function |
Edema factor (EF), which constitutes one of the three proteins composing the anthrax toxin, causes edema in the host (PubMed:6285339, PubMed:2108958, PubMed:11807546). Acts as a calmodulin-dependent adenylyl cyclase by converting ATP to cAMP, leading to dramatic elevation of intracellular cAMP levels in the host, thereby causing edema (PubMed:6285339, PubMed:2108958, PubMed:11807546). EF is not toxic by itself and only acts as an edema factor when associated with protective antigen (PA) to form the edema toxin (EdTx) (PubMed:11553601, PubMed:2108958). Required for the survival of germinated spores within macrophages at the early stages of infection (PubMed:11737637).
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| Uniprot ID |
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| Subcellular Location |
Secreted
Host cytoplasm
Host cytosol
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000014 , RAW 264.7
