General Information of the Protein
Protein ID
PT03887
Protein Name
Squalene monooxygenase
Secondarily
Protein Name
Squalene epoxidase
Gene Name
SQLE
Secondarily
Gene Name
ERG1
Sequence
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
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Uniprot ID
Primary ID:
Q14534

Secondarily ID:
Q9UEK6
Q9UNR6
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Ensembl ID
ENSG00000104549
HGNC ID
HGNC:11279
Subcellular Location
Microsome membrane
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0402849
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylthiophene-2-sulfonamide
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C25H34N2O3S2
  3
1
IC50 = 50 nM
 Bioactivity Info 
   TI
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2
IC50 = 60 nM
 Bioactivity Info 
   TI
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3
IC50 = 80 nM
 Bioactivity Info 
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CP0511406
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-ethylthiophene-2-sulfonamide
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C26H36N2O3S2
  1
1
IC50 = 90 nM
 Bioactivity Info 
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CP0521845
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-4-thiophen-3-ylthiophene-2-sulfonamide
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C29H36N2O3S3
  1
1
IC50 = 90 nM
 Bioactivity Info 
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CP0528979
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylpyridine-3-sulfonamide
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C26H35N3O3S
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0382953
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-propylthiophene-2-sulfonamide
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C27H38N2O3S2
  1
1
IC50 = 170 nM
 Bioactivity Info 
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CP0402838
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-1,3-thiazole-2-sulfonamide
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C24H33N3O3S2
  1
1
IC50 = 170 nM
 Bioactivity Info 
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CP0395170
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-1-thiophen-2-ylmethanesulfonamide
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C26H36N2O3S2
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0476703
 Compound Info 
4-Cyano-N-[2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-N-methyl-benzenesulfonamide
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C28H35N3O3S
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0491724
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-5-thiophen-3-ylthiophene-2-sulfonamide
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C29H36N2O3S3
  1
1
IC50 = 210 nM
 Bioactivity Info 
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CP0527471
 Compound Info 
N-cyclopropyl-N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]thiophene-2-sulfonamide
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C27H36N2O3S2
  1
1
IC50 = 230 nM
 Bioactivity Info 
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CP0476695
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylthiophene-3-sulfonamide
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C25H34N2O3S2
  1
1
IC50 = 250 nM
 Bioactivity Info 
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CP0511646
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-4-fluoro-N-methylbenzenesulfonamide
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C27H35FN2O3S
  1
1
IC50 = 255 nM
 Bioactivity Info 
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CP0535451
 Compound Info 
((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-{3-[3-(thiophene-2-sulfonyl)-propoxy]-benzyl}-amine
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C25H33NO3S2
  1
1
IC50 = 290 nM
 Bioactivity Info 
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CP0509995
 Compound Info 
4-Bromo-thiophene-2-sulfonic acid [2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-methyl-amide
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C25H33BrN2O3S2
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0509959
 Compound Info 
4-Bromo-N-[2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-N-methyl-benzenesulfonamide
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C27H35BrN2O3S
  1
1
IC50 = 330 nM
 Bioactivity Info 
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CP0498325
 Compound Info 
5-Bromo-thiophene-2-sulfonic acid [2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-methyl-amide
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C25H33BrN2O3S2
  1
1
IC50 = 390 nM
 Bioactivity Info 
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CP0389418
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]thiophene-2-sulfonamide
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C24H32N2O3S2
  1
1
IC50 = 450 nM
 Bioactivity Info 
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CP0402614
 Compound Info 
Benzo[b]thiophene-2-sulfonic acid [2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-methyl-amide
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C29H36N2O3S2
  1
1
IC50 = 1800 nM
 Bioactivity Info 
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CP0503070
 Compound Info 
N-[3-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]propyl]-N-methylthiophene-2-sulfonamide
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C26H36N2O3S2
  1
1
IC50 = 6400 nM
 Bioactivity Info 
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CP0540164
 Compound Info 
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-5-thiophen-2-ylthiophene-2-sulfonamide
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C29H36N2O3S3
  1
1
IC50 = 10000 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( Squalene monooxygenase (SQLE) )
Target Type Successful Target
Disease 3 Target-related Diseases  3
1 Dermatomycosis [ICD-11: EA60]
2 Dermatophytosis [ICD-11: 1F28.2]
3 Hepatic fibrosis [ICD-11: DB93.0]
Approved Drug(s) 2 Approved Drugs  2
1 Naftifine
 Drug Info 
Approved
Dermatomycosis
2 Tolnaftate
 Drug Info 
Approved
Dermatophytosis
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Epigallocatechin gallate
 Drug Info 
Phase 3
Hepatic fibrosis
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02359 Squalene monooxygenase Rattus norvegicus, Rat
 Protein Info