General Information of the Compound
Compound ID
CP0069098
Compound Name
MLS000028526
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Synonyms
2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate
Absorbine (TN)
Aftate
Aftate (TN)
Aftate for athlete's foot aerosol spray liquid
Aftate for athlete's foot aerosol spray powder
Aftate for athlete's foot gel
Aftate for athlete's foot sprinkle powder
Aftate for jock itch aerosol spray powder
Aftate for jock itch gel
Aftate for jock itch sprinkle powder
Bioglan Brand of Tolnaftate
Breezee
Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl ester
Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester
Carbanilic acid, N,m-dimethylthio-, O-2-naphthyl ester
Carbanilic acid, m,N-dimethylthio-, O-2-naphthyl ester
Carter Wallace Brand of Tolnaftate
Chinofungin
Chinosol Brand of Tolnaftate
Dermoxin
Douglas Brand of Tolnaftate
Dr. Scholl's athlete's foot spray
Dungistop
Essex Brand of Tolnaftate
Focusan
Fungistop
Genaspor
Genaspor (TN)
Genaspore cream
HI-Alazin
Hi-alarzin
Insight Brand of Tolnaftate
Isdin Brand of Tolnaftate
Lamasil AF (TN)
M,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester
Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester
Methyl-[3-methylphenyl]-carbamothioic acid O-2-naphthyl ester
Micoisdin
N-Methyl-(3-methylphenyl)-carbamothioic acid, O-2-naphthalenyl ester
NP 27
NP 27 (TN)
NP-27 Cream
NP-27 Powder
NP-27 Solution
NP-27 Spray Powder
NP27
Naphthiomate T
Naphthiomate-T
O-(2-Naphthyl) methyl(3-methylphenyl)thiocarbamate
O-2-Naphthyl N,N-dimethylthiocarbanilate
O-2-Naphthyl m,N-dimethylthiocarbanilate
O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
O-naphthalen-2-yl methyl(3-methylphenyl)carbamothioate
Odor Eaters (TN)
Ony Clear
Ony-Clear
Pedinol Brand 1 of Tolnaftate
Pedinol Brand 2 of Tolnaftate
Phytoderm
Pitrex
Pitrex cream
Purder N, Tolnaftat
Sch 10144
Schering Brand of Tolnaftate
Schering-Plough Brand 1 of Tolnaftate
Schering-Plough Brand 2 of Tolnaftate
Scholl (TN)
Separin
Separin (TN)
Sorgoa
Sporiline
Stiefel Brand of Tolnaftate
Thompson Brand of Tolnaftate
Timoped
Tinactin
Tinactin (TN)
Tinactin aerosol liquid
Tinactin aerosol powder
Tinactin antifungal deodorant powder aerosol
Tinactin cream
Tinactin jock itch aerosol powder
Tinactin jock itch cream;Tinactin jock itch spray powder
Tinactin plus aerosol powder
Tinactin plus powder
Tinactin powder
Tinactin solution
Tinaderm
Tinatox
Tinavet
Tinavet (Veterinary)
Ting
Ting (TN)
Ting Products
Ting antifungal cream
Ting antifungal powder
Ting antifungal spray liquid
Ting antifungal spray powder
Tniaderm
Tolnaftat Purder N
Tolnaftate
Tolnaftate (JP14/USP)
Tolnaftate (JP15/USP)
Tolnaftate (JP15/USP/INN)
Tolnaftate Douglas Brand
Tolnaftate Schering Brand
Tolnaftate [USAN:BAN:INN:JAN]
Tolnaftate [USAN:INN:BAN:JAN]
Tolnaftate(USAN)
Tolnaftato
Tolnaftato [DCIT]
Tolnaftato [INN-Spanish]
Tolnaftatum
Tolnaftatum [INN-Latin]
Tolnaphthate
Tolsanil
Tonoftal
Tritin
Wernigerode Brand of Tolnaftate
ZeaSorb
Zeasorb-AF powder
Zenith Brand of Tolnaftate
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Structure
Formula
C19H17NOS
Molecular Weight
307.418
Canonical SMILES
CN(C(=S)Oc1ccc2ccccc2c1)c1cccc(C)c1
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InChI
InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
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InChIKey
FUSNMLFNXJSCDI-UHFFFAOYSA-N
CAS
94256-64-1
2398-96-1
Physicochemical Property
logP
4.94832
Rotatable Bonds
2
Heavy Atom Count
22
Polar Areas
12.47
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5510
SID: 14849863
ChEMBL ID
CHEMBL83668
DrugBank ID
DB00525
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01049, Cytochrome P450 2C19
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Potency = 100 nM
Clinical Information about the Compound
Drug 1 ( Tolnaftate )
Drug Name Tolnaftate
Company Schering-Plough
Indication
Dermatophytosis
Approved
Jock itch
Approved
Target(s)
Squalene monooxygenase (SQLE)
Inhibitor