General Information of the Protein
Protein ID
PT03803
Protein Name
Alcohol dehydrogenase class-3
Secondarily
Protein Name
Alcohol dehydrogenase 5
Alcohol dehydrogenase class chi chain
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase
S-(hydroxymethyl)glutathione dehydrogenase
Gene Name
ADH5
Secondarily
Gene Name
ADHX
FDH
Sequence
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142).
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Uniprot ID
Primary ID:
P11766

Secondarily ID:
Q6FHR2
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Ensembl ID
ENSG00000197894
HGNC ID
HGNC:253
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0544449
 Compound Info 
US8906933, (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyrimidin-2(1H)-one
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C24H21N3O5
  1
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407171
 Compound Info 
US8906933, (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C21H18N4O5S
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413974
 Compound Info 
US8906933, (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C22H19N3O5S
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397812
 Compound Info 
US8906933, 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C22H19N3O5S
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0406431
 Compound Info 
US8906933, 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C21H18N4O5S
  1
1
IC50 = 24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0468280
 Compound Info 
US8906933, (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(pyridin-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C23H20N4O5
  1
1
IC50 = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0531133
 Compound Info 
US8906933, 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyrimidin-2(1H)-one
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C24H21N3O5
  1
1
IC50 = 29 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543353
 Compound Info 
US8906933, (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(1-methyl-1H-pyrazol-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C20H19N5O5S
  1
1
IC50 = 35 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0518418
 Compound Info 
US8906933, 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(1-methyl-1H-pyrazol-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C20H19N5O5S
  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0431790
 Compound Info 
US8906933, 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(pyridin-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C23H20N4O5
  1
1
IC50 = 43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0550613
 Compound Info 
US8906933, (S)-3-ethoxy-2-hydroxy-5-(2-oxo-6-(pyridin-3-yl)-5-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidin-4-yl)benzoic acid
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C22H21N3O5S
  1
1
IC50 = 67 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0414733
 Compound Info 
US8906933, 3-ethoxy-2-hydroxy-5-(2-oxo-6-(pyridin-3-yl)-5-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidin-4-yl)benzoic acid
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C22H21N3O5S
  1
1
IC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0468165
 Compound Info 
US8906933, (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
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C22H19N3O5S
  1
1
IC50 = 1820 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0429647
 Compound Info 
US8906933, (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
   Show/Hide
C21H18N4O5S
  1
1
IC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396437
 Compound Info 
US8906933, (R)-3-ethoxy-2-hydroxy-5-(2-oxo-6-(pyridin-3-yl)-5-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidin-4-yl)benzoic acid
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C22H21N3O5S
  1
1
IC50 = 3170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429601
 Compound Info 
US8906933, (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-6-(pyridin-3-yl)-3,4-dihydropyrimidin-2(1H)-one
   Show/Hide
C23H20N4O5
  1
1
IC50 = 6020 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0435232
 Compound Info 
US8906933, (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyrimidin-2(1H)-one
   Show/Hide
C24H21N3O5
  1
1
IC50 = 19720 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0385677
 Compound Info 
US8906933, (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(1-methyl-1H-pyrazol-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
   Show/Hide
C20H19N5O5S
  1
1
IC50 = 31000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS