General Information of the Protein
Protein ID
PT03751
Protein Name
Zinc finger protein GLI1
Secondarily
Protein Name
Glioma-associated oncogene
Oncogene GLI
Gene Name
GLI1
Secondarily
Gene Name
GLI
Sequence
MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETNSCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETEFLNSSA
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
Function
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24076122, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407).
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Uniprot ID
Primary ID:
P08151

Secondarily ID:
D0EUY3
E9PQQ9
F5H6H8
Q8TDN9
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Ensembl ID
ENSG00000111087
HGNC ID
HGNC:4317
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000426 , Shh Light II
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0947667
 Compound Info 
(4R,4aR,5R,11bS)-methyl 5-hydroxy-4,9,11b-trimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro-[2,3-d]oxazole-4-carboxylate
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C20H25NO4
  2
1
IC50 = 640 nM
 Bioactivity Info 
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2
IC50 = 1090 nM
 Bioactivity Info 
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CP0910829
 Compound Info 
(4R,4aR,5R,11bS)-ethyl 1,2,3,4,4a,5,6,11b-octahydro-5-hydroxy-4,11b-dimethylphenanthro[3,2-b]furan-4-carboxylate
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C21H26O4
  2
1
IC50 = 740 nM
 Bioactivity Info 
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2
IC50 = 860 nM
 Bioactivity Info 
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CP0136263
 Compound Info 
(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
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C27H41NO2
  1
1
IC50 = 5000 nM
 Bioactivity Info 
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CP0953661
 Compound Info 
(4R,4aR,5R,11bS)-N-benzyl-5-hydroxy-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro-[3,2-b]furan-4-carboxamide
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C26H29NO3
  1
1
IC50 = 5380 nM
 Bioactivity Info 
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CP0958027
 Compound Info 
(4R,4aR,5R,11bS)-4-(benzylcarbamoyl)-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-5-yl acetate
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C28H31NO4
  1
1
IC50 = 8980 nM
 Bioactivity Info 
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CP0909220
 Compound Info 
(4R,4aR,5R,11bS)-4-(methoxycarbonyl)-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-5-yl methyl succinate
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C25H30O7
  1
1
IC50 = 12340 nM
 Bioactivity Info 
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CP0910830
 Compound Info 
(4R,4aR,5R,11bS)-methyl 5-acetoxy-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-4-carboxylate
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C22H26O5
  1
1
IC50 = 12530 nM
 Bioactivity Info 
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CP0958028
 Compound Info 
(4R,4aR,5R,11bS)-methyl 5-hydroxy-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-4-carboxylate
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C20H24O4
  1
1
IC50 = 15850 nM
 Bioactivity Info 
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CP0853479
 Compound Info 
tert-butyl (3-((4R,4aR,5R,11bS)-5-hydroxy-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-4-carboxamido)propyl)carbamate
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C27H38N2O5
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0853480
 Compound Info 
(4R,4aR,5R,11bS)-methyl 5-acetoxy-4,8,11b-trimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro-[2,3-d]isoxazole-4-carboxylate
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C22H27NO5
  1
1
IC50 > 25000 nM
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CP0902056
 Compound Info 
(4R,4aR,5R,11bS)-methyl 5-(benzoyloxy)-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-4-carboxylate
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C27H28O5
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0902057
 Compound Info 
(4R,4aR,5R,11bS)-methyl 5-hydroxy-4,8,11b-trimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[2,3-d]isoxazole-4-carboxylate
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C20H25NO4
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0909219
 Compound Info 
(4R,4aR,5R,11bS)-4-((3-((tert-butoxycarbonyl)amino)propyl)carbamoyl)-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-5-yl acetate
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C29H40N2O6
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0942321
 Compound Info 
(4R,4aR,5R,11bS)-4,11b-dimethyl-4-(methylcarbamoyl)-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-5-yl acetate
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C22H27NO4
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0952556
 Compound Info 
(4R,4aR,5R,11bS)-methyl 5-acetoxy-4,9,11b-trimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro-[2,3-d]oxazole-4-carboxylate
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C22H27NO5
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0958025
 Compound Info 
(4R,4aR,5R,11bS)-1,2,3,4,4a,5,6,11b-octahydro-4-(hydroxymethyl)-4,11b-dimethylphenanthro[3,2-b]furan-5-ol
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C19H24O3
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0958026
 Compound Info 
(4R,4aR,5R,11bS)-5-hydroxy-N,4,11b-trimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-4-carboxamide
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C20H25NO3
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0962013
 Compound Info 
((4R,5R,11bS)-5-acetoxy-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-4-yl)methyl acetate
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C23H28O5
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( Zinc finger protein GLI1 (Gli1) )
Target Type Patented-recorded Target