General Information of the Compound
Compound ID
CP0909219
Compound Name
(4R,4aR,5R,11bS)-4-((3-((tert-butoxycarbonyl)amino)propyl)carbamoyl)-4,11b-dimethyl-1,2,3,4,4a,5,6,11b-octahydrophenanthro[3,2-b]furan-5-yl acetate
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Structure
Formula
C29H40N2O6
Molecular Weight
512.647
Canonical SMILES
CC(=O)O[C@@H]1Cc2cc3ccoc3cc2[C@@]2(C)CCC[C@@](C)(C(=O)NCCCNC(=O)OC(C)(C)C)[C@H]12
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InChI
InChI=1S/C29H40N2O6/c1-18(32)36-23-16-20-15-19-9-14-35-22(19)17-21(20)28(5)10-7-11-29(6,24(23)28)25(33)30-12-8-13-31-26(34)37-27(2,3)4/h9,14-15,17,23-24H,7-8,10-13,16H2,1-6H3,(H,30,33)(H,31,34)/t23-,24-,28-,29-/m1/s1
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InChIKey
GVHOIWNCJRBQRU-ALMNYQQGSA-N
Physicochemical Property
logP
5.0157
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
106.87
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145976815
ChEMBL ID
CHEMBL4204306
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03751, Zinc finger protein GLI1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000426 Shh Light II Mus musculus (Mouse)  1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS