General Information of the Protein
Protein ID
PT03712
Protein Name
Thyrotropin-releasing hormone receptor
Secondarily
Protein Name
Thyroliberin receptor
Gene Name
TRHR
Sequence
MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
    Show/Hide
Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neuropeptide receptor
Function
Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
    Show/Hide
Uniprot ID
Primary ID:
Q01717

Secondarily ID:
Q63948
Q63949
    Show/Hide
Ensembl ID
ENSG00000174417
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL001022 , HEK293EM
Compound ID Compound Name Compound Formula
CP0503792
1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propionyl]-5-oxo-pyrrolidine-2-carboxylic acid {2-((S)-2-carbamoyl-pyrrolidin-1-yl)-1-[(S)-1-(1H-imidazol-4-yl)methyl]-2-oxo-ethyl}-amide
   Show/Hide
C23H31N9O5
 2
1
EC50 = 0.5 nM
   TI
   LI
   LO
   TS
2
Ki = 3 nM
   TI
   LI
   LO
   TS
CP0067202
1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyrrolylcarboxamido)propanoyl]tetrahydro-1H-2-pyrrolecarboxamide
   Show/Hide
C16H22N6O4
 2
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
2
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0408102
1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-3-(2-propyl-1H-4-imidazolyl)-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide
   Show/Hide
C19H28N6O4
 2
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
2
Ki = 320 nM
   TI
   LI
   LO
   TS
CP0381542
1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide
   Show/Hide
C20H30N6O4
 2
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
2
Ki > 100000 nM
   TI
   LI
   LO
   TS
CP0391620
1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide
   Show/Hide
C26H36N6O4
 2
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
2
Ki > 100000 nM
   TI
   LI
   LO
   TS
CP0393980
1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide
   Show/Hide
C22H32N6O4
 2
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
2
Ki > 100000 nM
   TI
   LI
   LO
   TS
CP0431207
1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide
   Show/Hide
C19H28N6O4
 2
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
2
Ki > 100000 nM
   TI
   LI
   LO
   TS
CP0497471
1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide
   Show/Hide
C19H26N6O4
 2
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
2
Ki > 100000 nM
   TI
   LI
   LO
   TS