General Information of the Protein
Protein ID
PT03604
Protein Name
Secreted frizzled-related protein 1
Secondarily
Protein Name
Secreted apoptosis-related protein 2
Gene Name
SFRP1
Secondarily
Gene Name
FRP
FRP1
SARP2
Sequence
MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
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Uniprot ID
Primary ID:
Q8N474

Secondarily ID:
O00546
O14779
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Ensembl ID
ENSG00000104332
HGNC ID
HGNC:10776
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0198695
 Compound Info 
(S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate
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C28H34F3N3O7S2
  1
1
EC50 = 60 nM
 Bioactivity Info 
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CP0074574
 Compound Info 
5-(benzenesulfonyl)-N-[1-[6-(dimethylamino)pyridine-3-carbonyl]piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C26H27F3N4O5S2
  1
1
EC50 = 70 nM
 Bioactivity Info 
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CP0265625
 Compound Info 
tert-butyl (3R)-3-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]pyrrolidine-1-carboxylate
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C28H34F3N3O7S2
  1
1
EC50 = 80 nM
 Bioactivity Info 
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CP0074305
 Compound Info 
4-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]sulfonyl}benzoic acid
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C25H23F3N2O8S3
  1
1
EC50 = 110 nM
 Bioactivity Info 
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CP0147968
 Compound Info 
5-(benzenesulfonyl)-N-[1-(pyridine-3-carbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C24H22F3N3O5S2
  1
1
EC50 = 120 nM
 Bioactivity Info 
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CP0108523
 Compound Info 
5-(benzenesulfonyl)-N-[1-(6-morpholin-4-ylpyridine-3-carbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C28H29F3N4O6S2
  1
1
EC50 = 140 nM
 Bioactivity Info 
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CP0151328
 Compound Info 
5-(Phenylsulfonyl)-2-(trifluoromethyl)-N-(1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)benzenesulfonamide
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C25H21F6N3O5S2
  1
1
EC50 = 140 nM
 Bioactivity Info 
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CP0265624
 Compound Info 
5-(benzenesulfonyl)-N-[1-(6-chloropyridine-3-carbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C24H21ClF3N3O5S2
  1
1
EC50 = 140 nM
 Bioactivity Info 
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CP0212062
 Compound Info 
tert-butyl (3S)-3-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]pyrrolidine-1-carboxylate
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C28H34F3N3O7S2
  1
1
EC50 = 150 nM
 Bioactivity Info 
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CP0265626
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(piperidin-4-ylcarbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C24H28F3N3O5S2
  1
1
EC50 = 150 nM
 Bioactivity Info 
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CP0168224
 Compound Info 
5-(benzenesulfonyl)-N-[1-(3-cyanophenyl)sulfonylpiperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C25H22F3N3O6S3
  1
1
EC50 = 170 nM
 Bioactivity Info 
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CP0181362
 Compound Info 
3-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]sulfonyl}benzoic acid
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C25H23F3N2O8S3
  1
1
EC50 = 190 nM
 Bioactivity Info 
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CP0254325
 Compound Info 
5-(benzenesulfonyl)-N-[1-[4-(dimethylamino)benzoyl]piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C27H28F3N3O5S2
  1
1
EC50 = 190 nM
 Bioactivity Info 
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CP0151329
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(piperidin-4-ylacetyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C25H30F3N3O5S2
  1
1
EC50 = 210 nM
 Bioactivity Info 
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CP0212060
 Compound Info 
(R)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate
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C28H34F3N3O7S2
  1
1
EC50 = 210 nM
 Bioactivity Info 
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CP0328999
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(phenylsulfonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C24H23F3N2O6S3
  1
1
EC50 = 210 nM
 Bioactivity Info 
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CP0157377
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C24H22F3N3O5S2
  1
1
EC50 = 230 nM
 Bioactivity Info 
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CP0181363
 Compound Info 
4-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]benzoic acid
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C25H23F3N2O6S2
  1
1
EC50 = 230 nM
 Bioactivity Info 
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CP0212056
 Compound Info 
5-(Phenylsulfonyl)-N-{1-[(6-pyrrolidin-1-ylpyridin-3-yl)carbonyl]piperidin-4-yl}-2-(trifluoromethyl)benzenesulfonamide
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C28H29F3N4O5S2
  1
1
EC50 = 230 nM
 Bioactivity Info 
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CP0108522
 Compound Info 
5-(benzenesulfonyl)-N-(1-benzoylpiperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
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C25H23F3N2O5S2
  1
1
EC50 = 250 nM
 Bioactivity Info 
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CP0192098
 Compound Info 
2-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]acetamide
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C20H22F3N3O5S2
  1
1
EC50 = 310 nM
 Bioactivity Info 
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CP0265627
 Compound Info 
(S)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
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C23H26F3N3O5S2
  1
1
EC50 = 350 nM
 Bioactivity Info 
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CP0307969
 Compound Info 
3-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]benzoic acid
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C25H23F3N2O6S2
  1
1
EC50 = 350 nM
 Bioactivity Info 
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CP0265629
 Compound Info 
5-(Phenylsulfonyl)-N-{1-[(3R)-pyrrolidin-3-ylcarbonyl]-piperidin-4-yl}-2-(trifluoromethyl)benzenesulfonamide
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C23H26F3N3O5S2
  1
1
EC50 = 380 nM
 Bioactivity Info 
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CP0192099
 Compound Info 
4-Oxo-4-[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl}amino)piperidin-1-yl]butanoic acid
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C22H23F3N2O7S2
  1
1
EC50 = 400 nM
 Bioactivity Info 
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CP0212059
 Compound Info 
tert-butyl 4-[2-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxylate
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C30H38F3N3O7S2
  1
1
EC50 = 400 nM
 Bioactivity Info 
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CP0108524
 Compound Info 
tert-butyl 4-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]piperidine-1-carboxylate
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C29H36F3N3O7S2
  1
1
EC50 = 420 nM
 Bioactivity Info 
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CP0074576
 Compound Info 
2-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidin-1-yl]acetic acid
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C20H21F3N2O6S2
  1
1
EC50 = 570 nM
 Bioactivity Info 
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CP0192162
 Compound Info 
5-Oxo-5-[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl}amino)piperidin-1-yl]pentanoic acid
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C23H25F3N2O7S2
  1
1
EC50 = 570 nM
 Bioactivity Info 
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CP0095572
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(pyridin-2-ylcarbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C24H22F3N3O5S2
  1
1
EC50 = 600 nM
 Bioactivity Info 
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CP0108526
 Compound Info 
5-(benzenesulfonyl)-N-[1-(3-hydroxy-3-methylbutyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C23H29F3N2O5S2
  1
1
EC50 = 630 nM
 Bioactivity Info 
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CP0265628
 Compound Info 
5-(Phenylsulfonyl)-N-{1-[(3S)-pyrrolidin-3-ylcarbonyl]-piperidin-4-yl}-2-(trifluoromethyl)benzenesulfonamide
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C23H26F3N3O5S2
  1
1
EC50 = 700 nM
 Bioactivity Info 
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CP0192160
 Compound Info 
(R)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
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C23H26F3N3O5S2
  1
1
EC50 = 710 nM
 Bioactivity Info 
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CP0212064
 Compound Info 
5-(benzenesulfonyl)-N-[1-(3-hydroxypropyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C21H25F3N2O5S2
  1
1
EC50 = 850 nM
 Bioactivity Info 
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CP0300648
 Compound Info 
5-(benzenesulfonyl)-N-[1-(3-chlorobenzoyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C25H22ClF3N2O5S2
  1
1
EC50 = 870 nM
 Bioactivity Info 
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CP0265623
 Compound Info 
5-(Phenylsulfonyl)-2-(trifluoromethyl)-N-{1-[4-(trifluoromethyl)benzoyl]piperidin-4-yl}benzenesulfonamide
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C26H22F6N2O5S2
  1
1
EC50 = 970 nM
 Bioactivity Info 
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CP0151330
 Compound Info 
3-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]propanoic acid
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C21H23F3N2O6S2
  1
1
EC50 = 1200 nM
 Bioactivity Info 
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CP0168223
 Compound Info 
5-(Phenylsulfonyl)-N-(1-{[3-(2H-tetrazol-5-yl)phenyl]-sulfonyl}piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
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C25H23F3N6O6S3
  1
1
EC50 = 1200 nM
 Bioactivity Info 
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CP0317086
 Compound Info 
5-(benzenesulfonyl)-N-[1-(4-chlorobenzoyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C25H22ClF3N2O5S2
  1
1
EC50 = 1800 nM
 Bioactivity Info 
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CP0191420
 Compound Info 
5-(benzenesulfonyl)-N-[1-(2-chlorobenzoyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C25H22ClF3N2O5S2
  1
1
EC50 = 1900 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0074305
 Compound Info 
4-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]sulfonyl}benzoic acid
   Show/Hide
C25H23F3N2O8S3
  1
1 IC50 = 20 nM
CP0181362
 Compound Info 
3-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]sulfonyl}benzoic acid
   Show/Hide
C25H23F3N2O8S3
  1
1 IC50 = 20 nM
CP0168223
 Compound Info 
5-(Phenylsulfonyl)-N-(1-{[3-(2H-tetrazol-5-yl)phenyl]-sulfonyl}piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C25H23F3N6O6S3
  1
1 IC50 = 30 nM
CP0074574
 Compound Info 
5-(benzenesulfonyl)-N-[1-[6-(dimethylamino)pyridine-3-carbonyl]piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C26H27F3N4O5S2
  1
1 IC50 = 40 nM
CP0265628
 Compound Info 
5-(Phenylsulfonyl)-N-{1-[(3S)-pyrrolidin-3-ylcarbonyl]-piperidin-4-yl}-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H26F3N3O5S2
  1
1 IC50 = 40 nM
CP0151328
 Compound Info 
5-(Phenylsulfonyl)-2-(trifluoromethyl)-N-(1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)benzenesulfonamide
   Show/Hide
C25H21F6N3O5S2
  1
1 IC50 = 50 nM
CP0265625
 Compound Info 
tert-butyl (3R)-3-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]pyrrolidine-1-carboxylate
   Show/Hide
C28H34F3N3O7S2
  1
1 IC50 = 50 nM
CP0198695
 Compound Info 
(S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate
   Show/Hide
C28H34F3N3O7S2
  1
1 IC50 = 60 nM
CP0157377
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H22F3N3O5S2
  1
1 IC50 = 60 nM
CP0192098
 Compound Info 
2-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]acetamide
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C20H22F3N3O5S2
  1
1 IC50 = 60 nM
CP0265629
 Compound Info 
5-(Phenylsulfonyl)-N-{1-[(3R)-pyrrolidin-3-ylcarbonyl]-piperidin-4-yl}-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H26F3N3O5S2
  1
1 IC50 = 60 nM
CP0108522
 Compound Info 
5-(benzenesulfonyl)-N-(1-benzoylpiperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C25H23F3N2O5S2
  1
1 IC50 = 70 nM
CP0212062
 Compound Info 
tert-butyl (3S)-3-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]pyrrolidine-1-carboxylate
   Show/Hide
C28H34F3N3O7S2
  1
1 IC50 = 70 nM
CP0147968
 Compound Info 
5-(benzenesulfonyl)-N-[1-(pyridine-3-carbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H22F3N3O5S2
  1
1 IC50 = 80 nM
CP0168224
 Compound Info 
5-(benzenesulfonyl)-N-[1-(3-cyanophenyl)sulfonylpiperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C25H22F3N3O6S3
  1
1 IC50 = 90 nM
CP0151329
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(piperidin-4-ylacetyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C25H30F3N3O5S2
  1
1 IC50 = 100 nM
CP0307969
 Compound Info 
3-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]benzoic acid
   Show/Hide
C25H23F3N2O6S2
  1
1 IC50 = 100 nM
CP0265627
 Compound Info 
(S)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H26F3N3O5S2
  1
1 IC50 = 110 nM
CP0265624
 Compound Info 
5-(benzenesulfonyl)-N-[1-(6-chloropyridine-3-carbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H21ClF3N3O5S2
  1
1 IC50 = 110 nM
CP0212060
 Compound Info 
(R)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate
   Show/Hide
C28H34F3N3O7S2
  1
1 IC50 = 120 nM
CP0181363
 Compound Info 
4-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]benzoic acid
   Show/Hide
C25H23F3N2O6S2
  1
1 IC50 = 120 nM
CP0265626
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(piperidin-4-ylcarbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H28F3N3O5S2
  1
1 IC50 = 120 nM
CP0108523
 Compound Info 
5-(benzenesulfonyl)-N-[1-(6-morpholin-4-ylpyridine-3-carbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C28H29F3N4O6S2
  1
1 IC50 = 130 nM
CP0328999
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(phenylsulfonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H23F3N2O6S3
  1
1 IC50 = 130 nM
CP0074576
 Compound Info 
2-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidin-1-yl]acetic acid
   Show/Hide
C20H21F3N2O6S2
  1
1 IC50 = 190 nM
CP0192160
 Compound Info 
(R)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H26F3N3O5S2
  1
1 IC50 = 200 nM
CP0095572
 Compound Info 
5-(Phenylsulfonyl)-N-[1-(pyridin-2-ylcarbonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H22F3N3O5S2
  1
1 IC50 = 200 nM
CP0108526
 Compound Info 
5-(benzenesulfonyl)-N-[1-(3-hydroxy-3-methylbutyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H29F3N2O5S2
  1
1 IC50 = 200 nM
CP0191420
 Compound Info 
5-(benzenesulfonyl)-N-[1-(2-chlorobenzoyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C25H22ClF3N2O5S2
  1
1 IC50 = 200 nM
CP0192099
 Compound Info 
4-Oxo-4-[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl}amino)piperidin-1-yl]butanoic acid
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C22H23F3N2O7S2
  1
1 IC50 = 270 nM
CP0108524
 Compound Info 
tert-butyl 4-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]piperidine-1-carboxylate
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C29H36F3N3O7S2
  1
1 IC50 = 300 nM
CP0254325
 Compound Info 
5-(benzenesulfonyl)-N-[1-[4-(dimethylamino)benzoyl]piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C27H28F3N3O5S2
  1
1 IC50 = 300 nM
CP0300648
 Compound Info 
5-(benzenesulfonyl)-N-[1-(3-chlorobenzoyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C25H22ClF3N2O5S2
  1
1 IC50 = 300 nM
CP0317086
 Compound Info 
5-(benzenesulfonyl)-N-[1-(4-chlorobenzoyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C25H22ClF3N2O5S2
  1
1 IC50 = 300 nM
CP0265623
 Compound Info 
5-(Phenylsulfonyl)-2-(trifluoromethyl)-N-{1-[4-(trifluoromethyl)benzoyl]piperidin-4-yl}benzenesulfonamide
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C26H22F6N2O5S2
  1
1 IC50 = 400 nM
CP0212059
 Compound Info 
tert-butyl 4-[2-[4-[[5-(benzenesulfonyl)-2-(trifluoromethyl)phenyl]sulfonylamino]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxylate
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C30H38F3N3O7S2
  1
1 IC50 = 490 nM
CP0192162
 Compound Info 
5-Oxo-5-[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl}amino)piperidin-1-yl]pentanoic acid
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C23H25F3N2O7S2
  1
1 IC50 = 500 nM
CP0212064
 Compound Info 
5-(benzenesulfonyl)-N-[1-(3-hydroxypropyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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C21H25F3N2O5S2
  1
1 IC50 = 500 nM
CP0212056
 Compound Info 
5-(Phenylsulfonyl)-N-{1-[(6-pyrrolidin-1-ylpyridin-3-yl)carbonyl]piperidin-4-yl}-2-(trifluoromethyl)benzenesulfonamide
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C28H29F3N4O5S2
  1
1 IC50 = 870 nM
CP0151330
 Compound Info 
3-[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]propanoic acid
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C21H23F3N2O6S2
  1
1 IC50 = 900 nM
CP0635352
 Compound Info 
(rac)-methyl 2-(2-(2-imino-4-oxothiazolidin-5-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate
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C13H15N3O4S2
  1
1 Kd = 720 nM